Anti-Inflammatory Effects of Cicadidae Periostracum Extract and Oleic Acid through Inhibiting Inflammatory Chemokines Using PCR Arrays in LPS-Induced Lung inflammation In Vitro

Hong, Jung-Hee; Lee, Young‐Cheol

doi:10.3390/life12060857

Cited by 8 publications

(3 citation statements)

References 132 publications

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“…Hou et al reported that OA supplementation increases the AMP/ATP ratio and AMPK activation, as well as inhibiting the NF-κB pathway in M1 [ 117 ]. Moreover, Hong et al proved that OA treatments have anti-inflammatory effects through inhibiting proinflammatory mediators, including PI3K, Akt, MAPKs, NF-κB, NOS2, and COX2 in M1 [ 118 ]. Regarding T cells, Gorjão et al demonstrated that OA stimulates T lymphocytes, inducing their proliferation, while other saturated or n -3 fatty acids decrease it [ 160 ].…”

Section: Resultsmentioning

confidence: 99%

Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism

et al. 2023

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Nutraceuticals act as cellular and functional modulators, contributing to the homeostasis of physiological processes. In an inflammatory microenvironment, these functional foods can interact with the immune system by modulating or balancing the exacerbated proinflammatory response. In this process, immune cells, such as antigen-presenting cells (APCs), identify danger signals and, after interacting with T lymphocytes, induce a specific effector response. Moreover, this conditions their change of state with phenotypical and functional modifications from the resting state to the activated and effector state, supposing an increase in their energy requirements that affect their intracellular metabolism, with each immune cell showing a unique metabolic signature. Thus, nutraceuticals, such as polyphenols, vitamins, fatty acids, and sulforaphane, represent an active option to use therapeutically for health or the prevention of different pathologies, including obesity, metabolic syndrome, and diabetes. To regulate the inflammation associated with these pathologies, intervention in metabolic pathways through the modulation of metabolic energy with nutraceuticals is an attractive strategy that allows inducing important changes in cellular properties. Thus, we provide an overview of the link between metabolism, immune function, and nutraceuticals in chronic inflammatory processes associated with obesity and diabetes, paying particular attention to nutritional effects on APC and T cell immunometabolism, as well as the mechanisms required in the change in energetic pathways involved after their activation.

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Section: Resultsmentioning

confidence: 99%

Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism

et al. 2023

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“…In neutrophils, OA can reduce their migration ability (62). In macrophages, it can inhibit the production of pro-inflammatory factors and promote the secretion of anti-inflammatory factors (63)(64)(65). OA can also affect the physiological processes of T cells and regulate the function of Treg cells (66)(67)(68).…”

Section: Discussionmentioning

confidence: 99%

Serum albumin levels and risk of atrial fibrillation: a Mendelian randomization study

Chen,

Wang,

2024

Front. Cardiovasc. Med.

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ObjectiveAlthough several observational studies have linked serum albumin to cardiovascular disease and considered it as an important biomarker, little is known about whether increasing or maintaining serum albumin levels can effectively improve the prognosis of patients with atrial fibrillation. Therefore, this study aims to further explore the causal relationship between serum albumin and atrial fibrillation and its potential mechanism.MethodUsing data from large-scale genome-wide association studies, we conducted a two-sample Mendelian randomization (MR) analysis and a mediation MR analysis, using serum albumin as the exposure variable and atrial fibrillation as the outcome variable. We included 486 serum metabolites as potential mediating factors. To increase the robustness of the analysis, we applied five statistical methods, including inverse variance weighted, weighted median, MR-Egger, simple mode, and weighted mode. Validate the MR results using Bayesian weighted Mendelian randomization method.ResultThe results of the MR analysis indicate a significant inverse association between genetically predicted serum albumin concentration (g/L) and the risk of atrial fibrillation (Beta = −0.172, OR = 0.842, 95% CI: 0.753–0.941, p = 0.002). Further mediation MR analysis revealed that serum albumin may mediate the causal relationship with atrial fibrillation by affecting two serum metabolites, docosatrienoate and oleate/vaccenate, and the mediating effect was significant. In addition, all our instrumental variables showed no heterogeneity and level-multiplicity in the MR analysis. To verify the stability of the results, we also conducted a sensitivity analysis using the leave-one-out method, and the results further confirmed that our findings were robust and reliable. Finally, we conducted a validation using the Bayesian weighted Mendelian randomization method, which demonstrated the reliability of our causal inference results.ConclusionThis study strongly demonstrates the causal relationship between serum albumin and reduced risk of atrial fibrillation through genetic methods, and reveals the key mediating role of two serum metabolites in this relationship. These findings not only provide a new perspective for our understanding of the role of serum albumin in atrial fibrillation, but also provide new ideas for the prevention and treatment strategies of atrial fibrillation.

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“…These authors suggested that OA might be used for the treatment of sepsis-caused acute liver injury. In the same cells, Hong and Lee found that OA treatments exert anti-inflammatory effects by inhibiting proinflammatory mediators, including PI3K, Akt, MAPKs, NFκB, NOS2, and COX2 [ 55 ]. These findings suggest that OA is a potential chemokine-based therapeutic substance for the treatment of the lungs and airway inflammation in allergic disorders.…”

Section: Oleic Acid and Immune Cellsmentioning

confidence: 99%

Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid

et al. 2023

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In 2010, the Mediterranean diet was recognized by UNESCO as an Intangible Cultural Heritage of Humanity. Olive oil is the most characteristic food of this diet due to its high nutraceutical value. The positive effects of olive oil have often been attributed to its minor components; however, its oleic acid (OA) content (70–80%) is responsible for its many health properties. OA is an effective biomolecule, although the mechanism by which OA mediates beneficial physiological effects is not fully understood. OA influences cell membrane fluidity, receptors, intracellular signaling pathways, and gene expression. OA may directly regulate both the synthesis and activities of antioxidant enzymes. The anti-inflammatory effect may be related to the inhibition of proinflammatory cytokines and the activation of anti-inflammatory ones. The best-characterized mechanism highlights OA as a natural activator of sirtuin 1 (SIRT1). Oleoylethanolamide (OEA), derived from OA, is an endogenous ligand of the peroxisome proliferator-activated receptor alpha (PPARα) nuclear receptor. OEA regulates dietary fat intake and energy homeostasis and has therefore been suggested to be a potential therapeutic agent for the treatment of obesity. OEA has anti-inflammatory and antioxidant effects. The beneficial effects of olive oil may be related to the actions of OEA. New evidence suggests that oleic acid may influence epigenetic mechanisms, opening a new avenue in the exploration of therapies based on these mechanisms. OA can exert beneficial anti-inflammatory effects by regulating microRNA expression. In this review, we examine the cellular reactions and intracellular processes triggered by OA in T cells, macrophages, and neutrophils in order to better understand the immune modulation exerted by OA.

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Anti-Inflammatory Effects of Cicadidae Periostracum Extract and Oleic Acid through Inhibiting Inflammatory Chemokines Using PCR Arrays in LPS-Induced Lung inflammation In Vitro

Cited by 8 publications

References 132 publications

Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism

Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism

Serum albumin levels and risk of atrial fibrillation: a Mendelian randomization study

Update on Anti-Inflammatory Molecular Mechanisms Induced by Oleic Acid

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