Anti-inflammatory effects of flavonoids in Korean Chrysanthemum species via suppression of inducible nitric oxide synthase and cyclooxygenase-2 in LPS-induced RAW 264.7 macrophages

Kim, Su Jeong; Lee, Kyung‐Tae; Choi, Hyun‐Chul; Ha, Tae Joung; Nam, Jung‐Hwan; Hong, Su Young; Chang, Dong Chil; Kim, Ki Sun

doi:10.1007/s10068-015-0125-9

Cited by 18 publications

(6 citation statements)

References 19 publications

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“…In previous phytochemical studies on C . morifolium , flavonoids and phenolic acids have been identified as major constituents [ 2 ], which have exhibited diverse biological activities such as antioxidant [ 3 ], anti-inflammatory [ 4 ], and antitumor effects [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Quantification of Antioxidant Phenolic Compounds in a New Chrysanthemum Cultivar by High-Performance Liquid Chromatography with Diode Array Detection and Electrospray Ionization Mass Spectrometry

Han

Kim

et al. 2017

International Journal of Analytical Chemistry

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The flowers of Chrysanthemum morifolium Ramat. have been used as an herbal tea and in traditional medicine, and the plant has been developed to produce horticultural cultivars of various colors and shapes. In this study, a new chrysanthemum cultivar with dark purple petals (C. morifolium cv. ARTI-Dark Chocolate; ADC) was developed by radiation-induced mutation breeding of its original cultivar with purple striped white petals (C. morifolium cv. Noble Wine, NW). The phenolic profile and antioxidant property of ADC were investigated and compared with NW and the commercially available medicinal herb, C. morifolium with yellow petals (CM), in order to find a scientific support to produce a new source of natural antioxidant. Flavonoid and phenolic acid profiles of the ethanol extracts of the three flowers were analyzed by high-performance liquid chromatography-diode array detector-electrospray ionization mass spectrometry (HPLC-DAD-ESIMS), while antioxidant properties were evaluated using the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging assay. Among the tested flowers, ADC possessed the strongest antioxidant capacity and the highest phenolic contents. Flavonoids (acacetin, apigenin, luteolin, acacetin-7-O-β-glucoside, apigenin-7-O-β-glucoside, luteolin-7-O-β-glucoside, and linarin) and phenolic acids (chlorogenic acid and mixture of 1,4-, 1,5-, and 3,5-dicaffeoylquinic acids) were identified and quantified.

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Section: Introductionmentioning

confidence: 99%

Quantification of Antioxidant Phenolic Compounds in a New Chrysanthemum Cultivar by High-Performance Liquid Chromatography with Diode Array Detection and Electrospray Ionization Mass Spectrometry

Han

Kim

et al. 2017

International Journal of Analytical Chemistry

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“…All the experiments were performed in triplicate and results were averaged. Linear regression was used to calculate the IC 50 values 9 .…”

Section: Discussionmentioning

confidence: 99%

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2018

IJPSR

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Free radicals are toxic by products of natural cell metabolism and are responsible for causing a wide number of health problems. Okra is a one of the traditional plant scientifically known as Abelmoschus esculentus Linn. belong to the family Mallow, having rich nutritional value and proved to have many therapeutic uses, various parts of this plant is used in different types of treatment, preparation of pharmaceutical products and also used in preparation of fibers. Scientifically leaf extract of Abelmoschus esculentus proved to have antipyretic, antispasmodic, anti-cancer, immuno modulatory activity. In this study petroleum ether extract, chloroform, Ethanolic extracts of Abelmoschus esculentus Linn. leaves were evaluated in-vitro by experimental parameters such as DPPH scavenging activity, Nitric oxide radical, Hydroxyl radical scavenging, superoxide dismutase scavenging capacity. Abelmoschus esculentus Linn. is used as an antioxidant, antidiabetics, hepatoprotective, cytotoxic activity, genetoxicity, antitumour activity, antilice agent. It is related to contain alkaloids, carbohydrates, fixed oils, tannins and phenolic.

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“…Further, it has reported health benefits as chrysanthemum flowers possess anti-inflammatory, anti-pyretic, sedative, anti-arthritic, and anti-hypertensive effects [1]. Chrysanthemum flowers have also been demonstrated to produce various types of flavonoids [2,3,4,5], phenolic acids [2,6,7,8], and lignans [9], which have exhibited diverse biological activities such as antioxidant [3,6], anti-inflammatory [4], antitumor [5], neuroprotective [7,9], and anti-allergic activities [10]. The properties and concentrations of such constituents are responsible for the functional characteristics of chrysanthemum and are important from a commercial point of view.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Composition and Antioxidant Activities of Two Different Color Chrysanthemum Flower Teas

et al. 2019

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Chrysanthemum morifolium Ramat is a perennial flowering plant widely cultivated for use in a tea infusion and as a popular beverage. To identify and evaluate the tea infusion made with a γ-irradiated mutant chrysanthemum cultivar with dark purple petals (cv. ARTI-Dark Chocolate), its phytochemical composition and antioxidant activity were tested and compared with those of the commercially available chrysanthemum cultivar with yellow petals (cv. Gamguk) by HPLC-DAD-ESIMS, as well as DPPH and ABTS radical scavenging assays. The purple chrysanthemum tea contained anthocyanins and linarin, which were not detected in the yellow chrysanthemum tea and the content of chlorogenic acid, acacetin-7-O-β-glucoside, and luteolin was higher compared with the yellow chrysanthemum tea. In contrast, the yellow chrysanthemum tea had higher luteolin-7-O-β-glucoside, 3,5-dicaffeoylquinic acid, apigenin-7-O-β-glucoside, and apigenin contents in comparison with the purple chrysanthemum tea. In addition, the content and antioxidant activity of the two chrysanthemum teas were investigated according to different water temperatures and infusing time. The yellow chrysanthemum tea did not show any significant differences according to infusing time and temperature, while the purple chrysanthemum tea was more influenced by the infusing time than water temperature, showing the highest total compound content in the infusing condition of 100 °C and 4 min. Moreover, the floral scent volatiles of the two chrysanthemum tea sources were analyzed using HS-SPME-GC-MS. In the DPPH radical scavenging assay, the purple chrysanthemum tea broadly showed greater antioxidant activity than did the yellow chrysanthemum tea, corresponding to the high content of anthocyanins known as the powerful antioxidant. Further, both chrysanthemum flower teas exhibited strong ABTS radical scavenging effects ranging from 76% to 61% under all infusing conditions. Therefore, the purple chrysanthemum cultivar, ARTI-Dark Chocolate, is worthy of breeding as a new tea cultivar.

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Anti-inflammatory effects of flavonoids in Korean Chrysanthemum species via suppression of inducible nitric oxide synthase and cyclooxygenase-2 in LPS-induced RAW 264.7 macrophages

Cited by 18 publications

References 19 publications

Quantification of Antioxidant Phenolic Compounds in a New Chrysanthemum Cultivar by High-Performance Liquid Chromatography with Diode Array Detection and Electrospray Ionization Mass Spectrometry

Quantification of Antioxidant Phenolic Compounds in a New Chrysanthemum Cultivar by High-Performance Liquid Chromatography with Diode Array Detection and Electrospray Ionization Mass Spectrometry

Untitled

Phytochemical Composition and Antioxidant Activities of Two Different Color Chrysanthemum Flower Teas

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