Anti-inflammatory effects of H2S during acute bacterial infection: a review

Benedetti, Francesca; Curreli, Sabrina; Krishnan, Selvi; Davinelli, Sergio; Cocchi, Fiorenza; Scapagnini, Giovanni; Gallo, Robert C.; Zella, Davide

doi:10.1186/s12967-017-1206-8

Cited by 62 publications

(53 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Robles‐Vera et al found that rats who received l ‐NAME had higher mRNA levels of IFN‐γ, which is produced by T helper‐1 cells infiltrating the aorta. Benedetti et al reported that IFN‐γ is responsible for the structural and haemodynamic changes in hypertension and that its deficiency resulted in the attenuation of hypertension.…”

Section: Discussionsupporting

confidence: 90%

Effects of hydrogen sulphide on oxidative stress, inflammatory cytokines, and vascular remodelling in l‐NAME‐induced hypertension

Allah

Ahmed

Makboul

et al. 2020

Clin Exp Pharma Physio

View full text Add to dashboard Cite

This study was designed to evaluate the protective effects of hydrogen sulphide (H2S) against NG‐Nitro l‐Arginine Methyl Ester (l‐NAME)‐induced hypertension and its possible effects on the inflammatory process, oxidative stress, and vascular remodelling in rats. Forty male Wistar Albino rats were assigned to four equal groups: the control group, the H2S control group, the hypertensive group, and the treated group, which received concomitant treatment with sodium hydrosulphide (NaHS) and l‐NAME. Systolic blood pressure (SBP) was measured weekly. Serum levels of nitric oxide (NO), total peroxide, and total antioxidant capacity (TAC) were measured and the oxidative stress index (OSI) was calculated. Aortic weight and length were measured and the aortic weight/length ratio determined. Aortic fold expression of interferon‐γ (IFN‐γ) and vascular cell adhesion molecule‐1 (VCAM‐1) mRNA was measured using qPCR. Aortic media thickness and elastin content were measured morphometrically. l‐NAME administration increased SBP, serum levels of total peroxide and OSI, but reduced serum levels of NO and TAC. Aortic fold expression of IFN‐γ and VCAM‐1 mRNA, aortic weight, aortic weight/length ratio, aortic media thickness, and elastin area percentage were increased in the hypertensive group. Concurrent administration of l‐NAME and H2S attenuated these changes. Thus, H2S could attenuate the increase in ABP through restoration of the NO level, reduction in the oxidative state, and attenuation of the inflammatory process, thereby reduced vascular remodelling.

show abstract

Section: Discussionsupporting

confidence: 90%

Effects of hydrogen sulphide on oxidative stress, inflammatory cytokines, and vascular remodelling in l‐NAME‐induced hypertension

Allah

Ahmed

Makboul

et al. 2020

Clin Exp Pharma Physio

View full text Add to dashboard Cite

show abstract

“…H 2 S was found to inhibit the induction of an inflammatory response on infection with Mycoplasma fermentans . Underlying mechanism revealed that H 2 S inhibited the activation and nuclear translocation of a redox sensitive transcription factor NF‐κB, thereby diminishing the transcription of proinflammatory genes . One of the mechanism by which H 2 S affects the activity of a global transcriptional regulator, NF‐κB, is by persulfidation of Cys‐38 residue in the p65 subunit .…”

Section: H2s and Host–pathogen Interactionmentioning

confidence: 99%

Hydrogen sulfide in physiology and pathogenesis of bacteria and viruses

2018

View full text Add to dashboard Cite

SummaryAn increasing number of studies have established hydrogen sulfide (H2S) gas as a major cytoprotectant and redox modulator. Following its discovery, H2S has been found to have pleiotropic effects on physiology and human health. H2S acts as a gasotransmitter and exerts its influence on gastrointestinal, neuronal, cardiovascular, respiratory, renal, and hepatic systems. Recent discoveries have clearly indicated the importance of H2S in regulating vasorelaxation, angiogenesis, apoptosis, ageing, and metabolism. Contrary to studies in higher organisms, the role of H2S in the pathophysiology of infectious agents such as bacteria and viruses has been less studied. Bacterial and viral infections are often accompanied by changes in the redox physiology of both the host and the pathogen. Emerging studies indicate that bacterial-derived H2S constitutes a defense system against antibiotics and oxidative stress. The H2S signaling pathway also seems to interfere with redox-based events affected on infection with viruses. This review aims to summarize recent advances on the emerging role of H2S gas in the bacterial physiology and viral infections. Such studies have opened up new research avenues exploiting H2S as a potential therapeutic intervention.

show abstract

“…The variation in mycoplasma lipoproteins attributed to genome rearrangements and genetic insertions have been demonstrated to lead to phenotypic plasticity that allows also for the evasion of the host's defense system and pathogenesis [13][14][15]. Some strains of mycoplasma can invade intracellularly [16][17][18], including Mycoplasma fermentans [19], enhancing their ability to evade the immune system [20]. Given their presence on mostly mucosal surfaces (respiratory and urogenital tracts, eyes, alimentary canal, mammary glands and joints [21][22][23]), mycoplasmas have been associated to respiratory [24,25], urogenital [26][27][28] and rheumatoid diseases [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Proteome analysis of Mycoplasma fermentans cultured under aerobic and anaerobic conditions

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background and aims: Mycoplasmas are ubiquitous pathogens found not only in humans but also in animals, plants, insects and soil. Though they usually grow better in an aerobic environment, mycoplasmas are also facultative anaerobic microorganisms. Following infection, the transition of a microorganism from a normal environment into an anaerobic one (e.g. dead or dying tissue) may result in production of a higher number of bacterial toxins. The resolution of the bacterial proteome during the aerobic/anaerobic switch could thus allow the identification of potential pathogenic determinants and pathways. Methods: We used two-dimensional gel electrophoresis (2-DE) coupled with matrix-assisted laser desorption/ ionization time-of-flight/tandem mass spectroscopy (MALDI-TOF MS/MS) and subsequent mass spectrometric analysis to characterize the liposoluble and hydrosoluble protein fractions of a strain of Mycoplasma fermentans isolated in our lab (MFI), that was cultured under either aerobic or anaerobic conditions. Results:We identified the 27 most abundant proteins in the liposoluble fraction and the 30 most abundant proteins in the hydrosoluble fraction and determined their modulation under aerobic and anaerobic growth. By using Protein ANalysis TrougH Evolutionary Relationships (PANTHER) and the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) software analysis tools, we were able to identify, define and organize the function of each protein, as well as to determine the specific interactome. Conclusions: Our work provides the first proteome reference map of Mycoplasma fermentans obtained under aerobic and anaerobic growing conditions. These data may help to better understand the mechanisms of pathogenicity of this microorganism and define new diagnostic targets.

show abstract

Anti-inflammatory effects of H2S during acute bacterial infection: a review

Cited by 62 publications

References 97 publications

Effects of hydrogen sulphide on oxidative stress, inflammatory cytokines, and vascular remodelling in l‐NAME‐induced hypertension

Effects of hydrogen sulphide on oxidative stress, inflammatory cytokines, and vascular remodelling in l‐NAME‐induced hypertension

Hydrogen sulfide in physiology and pathogenesis of bacteria and viruses

Proteome analysis of Mycoplasma fermentans cultured under aerobic and anaerobic conditions

Contact Info

Product

Resources

About