Anti-inflammatory Effects ofAster yomenaExtracts by the Suppression of Inducible Nitric Oxide Synthase Expression

Abstract

Inflammation is a pathophysiological process that is known to be involved in numerous diseases. Microbial infection or tissue injury activates inflammatory responses, resulting in the induction of proinflammatory proteins including inducible nitric oxide synthase (iNOS). Aster yomena is used in traditional Korean remedies. Here, we investigated the effects of ethanol extracts of Aster yomena (EAY) on the expression of iNOS induced by ovalbumin (OVA), one of the major egg allergens, or lipopolysaccharide (LPS), a Toll-like receptor 4 agonist. EAY inhibited OVA-or LPS-induced NF-κB activation. EAY also suppressed OVA-or LPS-induced iNOS expression and nitrite production. These results suggest that EAY has the specific mechanism for anti-inflammatory responses and the potential to be developed as a potent anti-inflammatory and anti-allergic drug.

Neuroprotective effect ofAster yomena(Kitam.) Honda against hydrogen peroxide-induced oxidative stress in SH-SY5Y cells

“…On the contrary, treatment with EFAY down-regulated the expressions of IL-1β and COX-2. Earlier, it has been revealed that several phenolic compounds present in EFAY dysregulated interleukin-6 production in TNF-α stimulated MG-63 cells, proposing their role as anti-inflammatory agents [45]. Furthermore, EFAY lowered ovalbumin-and LPS-induced inflammation by down-regulating NF-κB and iNOS in RAW 264.7 cells [46].…”