Anti-inflammatory effects of inhaled beclomethasone dipropionate in nonatopic asthmatics

Hoshino, Makoto; Nakamura, Yutaka

doi:10.1183/09031936.96.09040696

Cited by 21 publications

(18 citation statements)

References 45 publications

(46 reference statements)

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“…Corticosteroid treatment has been shown to decrease airway mast cells [42–45], which contrasts with our findings of a trend to greater density of pulmonary mast cells in asthmatic patients that were having regular treatment. Andersson and colleagues have recently described the presence of site‐specific mast cell populations in healthy lungs, which differ not only in their expression of chymase/tryptase phenotype but on the expression of several mast cell mediators.…”

Section: Discussioncontrasting

confidence: 99%

Pulmonary periarterial inflammation in fatal asthma

Shiang

Mauad

Senhorini

et al. 2009

Clin Experimental Allergy

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Section: Discussioncontrasting

confidence: 99%

Pulmonary periarterial inflammation in fatal asthma

Shiang

Mauad

Senhorini

et al. 2009

Clin Experimental Allergy

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“…Hashino and Nakamura reported that Beclomethasone Dipropionate suppressed cellular infiltration in airways and improved hyper-responsiveness in non-atopic asthma. [18] Takemura showed although serum CRP level of steroid users was higher than in control group, this difference was statistically insignificant. [11] Sin et al .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of correlation between airway and serum inflammatory markers in asthmatic patients

2012

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Context:Asthma is one of the most common chronic diseases all over the world, resulting from a state of persistent sub-acute inflammation of the airways. Beside local inflammation, systemic inflammation is also present, which can be shown by increased levels of C-reactive protein (CRP). One of the most important cells in this disease is eosinophil, and sputum eosinophilia is used for its diagnosis.Aims:The purpose of the present study was to compare and evaluate the correlation between CRP level and sputum eosinophilia in asthmatic and control subjects.Materials and Methods:A total of 61 patients suffering from mild-to-moderate asthma participated in this study. They were divided into two groups based on whether they used inhaled steroid or not. Sputum was induced by ultrasonic nebulizer, and then samples of peripheral venous blood were collected to measure peripheral cell count and CRP by Enzyme-linked immunosorbent assay (ELISA). Thirty-seven healthy subjects were selected and their blood samples were taken. Thirty-seven healthy subjects were selected and their blood samples were taken.Results:Thirty asthmatic patients in user group (14 females/16 males) with the mean age of 39.4±9.37 years, 31 asthmatic patients in non-user group (13 females/18 males) with the mean age of 35.5±8.87 years, and 37 healthy controls (17 females/20 males) were included in our study. The mean serum concentration of CRP was 2.6 μg/mL, 3.32 μg/mL, and 1.16 μg/mL in user, non-user, and control groups, respectively. Compared to healthy controls, serum concentrations of high sensitivity-CRP (hs-CRP) significantly increased in the non-user group (P=0.0001), and user group as well. (P=0.016). The number of sputum eosinophils and peripheral blood eosinophils significantly increased in the non-users compared to the healthy controls (P=0.0001, P=0.003, respectively). In the non-user group, serum hs-CRP levels correlated negatively with FEV1 and positively with numbers of sputum eosinophils, which was not statistically significant. Atopy status, age, and sex did not affect hs-CRP levels in both asthmatic groups.Conclusions:It was found that serum concentrations of hs-CRP significantly increased in asthmatic patients, and in the steroid-native group it partly correlated with FEV1 and numbers of sputum eosinophils. It suggests that serum hs-CRP can indirectly indicate the degree of airway inflammation.

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“…The heterogenous source of tissue may be the reason for lack of difference in the number of the CD3‐ and MBP‐positive cells in this study. It was shown that treatment with inhaled steroids resulted in the decrease of cells positive for EG2, AA1 (antigen expressed on mast cells), CD3, CD4, and CD25 in nonatopic asthmatic patients 14 . We showed that the topical steroid treatment is effective in suppressing the inflammatory cell infiltration both in allergic and nonallergic patients.…”

Section: Discussionmentioning

confidence: 65%