Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses

Abstract

In horses with ischemia-injured jejunum, lidocaine administered IV reduced plasma prostaglandin E(2) metabolite concentration and mucosal COX-2 expression. Coadministration of lidocaine with flunixin ameliorated the flunixin-induced increase in mucosal neutrophil counts.

Use of cecal bypass via side-to-side ileocolic anastomosis without ileal transection for treatment of ileocecal intussusception in a Vietnamese pot-bellied pig (Sus scrofa)

“…Lidocaine CRI has been reported in the postoperative management of ileus and signs of pain in other species. 14 The pig of the present report had thickened small intestine oral to the anastomosis, and lidocaine was used in an attempt to decrease inflammation and signs of pain related to the affected intestine. The use of CRIs of lidocaine in pot-bellied pigs has not been studied or reported, to our knowledge.…”

Continuous caudal epidural analgesia for perioperative pain control after bilateral mastectomy in a mare

“…Combined with reports on adverse effects and toxicity at higher doses, this has led to the limited use of these drugs in the postoperative period (Muir 2010). Lidocaine alone or in combination has analgesic and anti-inflammatory effects in the conscious horse (Robertson and others 2005, Cook and others 2009), although central nervous system toxicity and cardiovascular system toxicity have been reported when higher plasma concentrations are reached during long-term therapy with systemic lidocaine in horses (Doherty and Seddighi 2010, Sanchez and Robertson 2014). Some adverse effects (increased heart and respiratory rate, excitation and muscle fasciculation) and ineffective analgesia have been reported in chronic pain studies after ketamine infusion (0.5–1 mg/kg/h) in standing horses (Fielding and others 2006, Muir 2010).…”

Membrane lipid interactions in intestinal ischemia/reperfusion-induced Injury

“…The expression of Cox 1 has primarily been reported in equine studies. In the equine jejunum, Cox 1 protein is constitutively expressed and is increased, as is Cox 2, at 18 hours reperfusion following a two hour ischemic period [10, 20]. Transcription of Cox 1 also increased, although not significantly, in response to 75 minutes of reduced blood flow to the jejunum [15].…”