Anti-inflammatory effects of Irisin in LPS-stimulated RAW264.7 macrophages by inhibiting the MAPK pathway

Ma, Yu-Ke; Du, Yukuan; Yang, Jingnan; He, Qiaoling; Wang, Huichao; Lin, Xiaoqing Diana

doi:10.21203/rs.3.rs-1658198/v1

Cited by 2 publications

(2 citation statements)

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“…Deletion and overexpression of irisin has been shown to exacerbate and ameliorate cardiac hypertrophy in rats with hypertension, respectively (45). As sotalol and pirinixic acid treatment both upregulate irisin expression, and pirinixic acid has hypertension mediating effects, it is probable that sotalol also exhibits anti-hypertensive properties (46; 47).…”

Section: Resultsmentioning

confidence: 99%

Drug Repurposing using consilience of Knowledge Graph Completion methods

Sinha

González

et al. 2023

Preprint

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While link prediction methods in knowledge graphs have been increasingly utilized to locate potential associations between compounds and diseases, they suffer from lack of sufficient evidence to prove why a drug and a disease may be indicated. This is especially true for knowledge graph embedding (KGE) based methods where a drug-disease indication is linked only by information gleaned from a vector representation. Complementary pathwalking algorithms can increase the confidence of drug repositioning candidates by traversing a knowledge graph. However, these methods heavily weigh the relatedness of drugs, through their targets, pharmacology or shared diseases. Furthermore, these methods rely on arbitrarily extracted paths as evidence of a compound to disease indication and lack the ability to make predictions on rare diseases. In this paper, we evaluate seven link prediction methods on a large biomedical knowledge graph on a drug repositioning task. We follow the principle of consilience, and combine the reasoning paths and predictions provided by probabilistic case-based reasoning (probCBR) with those of a KGE method, TransE, to identify putative drug repositioning indications. Finally, we highlight the utility of our approach through two potential repurposing indications.

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Section: Resultsmentioning

confidence: 99%

Drug Repurposing using consilience of Knowledge Graph Completion methods

Sinha

González

et al. 2023

Preprint

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“…In an experimental animal model of ulcerative colitis, it has been found that exogenous irisin modulates the intestinal microbiota (by altering the diversity of microorganisms in the stool) and suppresses inflammation in the intestinal mucosa, indicating that irisin has anti-inflammatory properties[ 13 ]. It has been suggested that the anti-inflammatory effects of irisin are related to the inhibition of cytotoxicity and apoptosis via inhibiting the mitogen-activated protein kinase pathway[ 14 ]. The sports activity is a barrier for patients with active Crohn’s disease (intestinal manifestations) because it flares up the symptoms[ 15 ].…”

Section: To the Editormentioning

confidence: 99%

Interaction between inflammatory bowel disease, physical activity, and myokines: Assessment of serum irisin levels

Al-Nimer

2024

World J Gastroenterol

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Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, showed a wide spectrum of intestinal and extra-intestinal manifestations, which rendered the patients physically inactive and impaired their quality of life. It has been found that physical activity is a non-pharmacological intervention that improves the quality of life for those patients. Irisin is one member of the myokines secreted by muscle contraction during exercise and could be used as an anti-inflammatory biomarker in assessing the physical activity of IBD patients. In addition, experimental studies showed that exogenous irisin significantly decreased the inflammatory markers and the histological changes of the intestinal mucosa observed in experimental colitis. Furthermore, irisin produces changes in the diversity of the microbiota. Therefore, endogenous or exogenous irisin, via its anti-inflammatory effects, will improve the health of IBD patients and will limit the barriers to physical activity in patients with IBD.

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Anti-inflammatory effects of Irisin in LPS-stimulated RAW264.7 macrophages by inhibiting the MAPK pathway

Cited by 2 publications

References 0 publications

Drug Repurposing using consilience of Knowledge Graph Completion methods

Drug Repurposing using consilience of Knowledge Graph Completion methods

Interaction between inflammatory bowel disease, physical activity, and myokines: Assessment of serum irisin levels

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