Anti‐inflammatory Effects of Limonene from Yuzu (<i>Citrus junos</i> Tanaka) Essential Oil on Eosinophils

Hirota, Ryoji; Roger, Ngatu Nlandu; Nakamura, Hiroyuki; Song, Hee-Sun; Sawamura, Masayoshi; Suganuma, Narufumi

doi:10.1111/j.1750-3841.2010.01541.x

Cited by 145 publications

(102 citation statements)

References 49 publications

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“…The use of a mixture of long-chain inulin and oligosaccharide in HLA-B27 transgenic rats exhibited some local anti-inflammatory properties, through the reduction of gross cecal and inflammatory histological scores in the cecum and colon, the decreased levels of the pro-inflammatory cytokine IL-1β, and the increased of the anti-inflammatory TGF-β (Hoentjen et al, 2005). The results of Hirota et al (2010) suggest that low concentrations of limonene from Yuzu, a traditional medicine used in Japan have anti-inflammatory effect by inhibiting cytokines, ROS production, and inactivating eosinophil migration. Limonene and beta-myrcene from essential oils of two species of Asteraceae produced also significantly less IFN-γ and IL-4 and inhibited cell migration when administered orally in a mouse model of pleurisy induced by zymosan and lipopolysaccharide (LPS) (Souza et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary natural supplements on immune response and mineral bioavailability in piglets after weaning

Ţăranu¹,

Marin²,

Untea³

et al. 2012

CZECH J ANIM SCI

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Plants and plant extracts (PPEs) have gained increasing interest as feed additives and possible replacing antibiotics for pig productions. The effects of dietary Chlorella vulgaris (1%), sodium alginate (0.1%), inulin (1.5%), and a mixture of essential oils (0.04%) supplements on immune response, and bioavailability of some micronutrients (iron − Fe, copper − Cu, manganese − Mn, and zinc − Zn) were investigated in weaned piglets in this study. The results showed that the concentration of IgG was increased in the plasma of pigs fed the PPEs supplemented diets being significantly higher (P < 0.05) in the case of dietary sodium alginate supplementation in comparison to the control (6.00 vs. 4.03 mg/ml). In liver, PPEs, especially inulin and essential oils, were able to modulate the level of cytokine production and mineral retention, resulting in higher liver concentration of IL-1β (125.4 and 88.9%), IL-8 (136.9 and 61.3%), TNF-a (296.6 and 121.6%), and IFN-γ (51.2 and 107.28%), Cu (71.31 ppm), and Fe (192.56 ppm) in comparison to the control. The results of this experiment indicate that natural supplements investigated herein, especially inulin, essential oils, and sodium alginate had the ability to potentiate both the immune function and mineral retention during the initial post weaning period.

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Section: Discussionmentioning

confidence: 99%

Effect of dietary natural supplements on immune response and mineral bioavailability in piglets after weaning

Ţăranu¹,

Marin²,

Untea³

et al. 2012

CZECH J ANIM SCI

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“…5,6) For example, anti-in ammatory and anti-cancer e ects of essential oils containing geraniol or limonene have been reported. [7][8][9] More interestingly, it has been reported that exposure of rat brain tissues to citrus avor components results in the release of dopamines. 10) e concentrations of MTs in air in a forest are below 1 ppm.…”

Section: Introductionmentioning

confidence: 99%

Conifer-Derived Monoterpenes and Forest Walking

et al. 2015

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Conifer and broadleaf trees emit volatile organic compounds in the summer. e major components of these emissions are volatile monoterpenes. Using solid phase microextraction ber as the adsorbant, monoterpenes were successfully detected and identi ed in forest air samples. Gas chromatography/mass chromatogram of monoterpenes in the atmosphere of a conifer forest and that of serum from subjects who were walking in a forest were found to be similar each other. e amounts of α-pinene in the subjects became several folds higher a er forest walking. e results indicate that monoterpenes in the atmosphere of conifer forests are transferred to and accumulate in subjects by inhalation while they are exposed to this type of environment.Please cite this article as: Mass Spectrom (Tokyo) 2015; 4(1): A0042

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“…The Japanese also use yuzu to make various sweets, including marmalade, jellies, and cakes. According to food and nutritional science studies, yuzu also possesses antioxidant, 2 anticarcinogenic, 3 anti-inflammatory, 4 and antidiabetic properties 5 and exhibits preventive effects on cognitive dysfunction. 6 The pale yellow essential oil extracted from yuzu rind by the cold expression method emits an exquisite citrus aroma.…”

Section: Introductionmentioning

confidence: 99%

Effects of Olfactory Stimulation from the Fragrance of the Japanese Citrus Fruit Yuzu (Citrus junos Sieb. ex Tanaka) on Mood States and Salivary Chromogranin A as an Endocrinologic Stress Marker

Matsumoto

Asakura²,

Hayashi

2014

The Journal of Alternative and Complementary Medicine

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Objective: This study investigated the soothing effects of fragrance from yuzu, a Japanese citrus fruit (Citrus junos Sieb. ex Tanaka), with salivary chromogranin A (CgA) used as an endocrinologic stress marker reflecting sympathetic nervous system activity. Methods: Twenty healthy women (mean age, 20.5 -0.1 years) participated in a randomized, controlled, crossover study. Participants were examined on two separate occasions-once using the yuzu scent and once using unscented water as a control-in the follicular phase. This experiment measured salivary CgA and the Profile of Mood States (POMS) as a psychological index before and after the aromatic stimulation. Results: Ten-minute inhalation of the yuzu scent significantly decreased salivary CgA. At 30 minutes after the inhalation period, the salivary CgA level further decreased. In addition, POMS revealed that inhalation of the aromatic yuzu oil significantly decreased total mood disturbance, a global measure of affective state, as well as four subscores of emotional symptoms (tension-anxiety, depression-dejection, anger-hostility, and confusion), as long as 30 minutes after the olfactory stimulation. Conclusions: Yuzu's aromatic effects may alleviate negative emotional stress, which, at least in part, would contribute to the suppression of sympathetic nervous system activity.

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Anti‐inflammatory Effects of Limonene from Yuzu (Citrus junos Tanaka) Essential Oil on Eosinophils

Cited by 145 publications

References 49 publications

Effect of dietary natural supplements on immune response and mineral bioavailability in piglets after weaning

Effect of dietary natural supplements on immune response and mineral bioavailability in piglets after weaning

Conifer-Derived Monoterpenes and Forest Walking

Effects of Olfactory Stimulation from the Fragrance of the Japanese Citrus Fruit Yuzu (Citrus junos Sieb. ex Tanaka) on Mood States and Salivary Chromogranin A as an Endocrinologic Stress Marker

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