Anti-inflammatory effects of medicinal plants mixture used by Bedouin people in Saudi Arabia

Elsharkawy, Eman; Elshathely, Mona; Jaleel, Gehad A. Abdel; AL-Johar, H.I.

doi:10.2478/hepo-2013-0018

Cited by 11 publications

(14 citation statements)

References 25 publications

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“…Retention indices were determined using retention times of n-alkanes that have been injected to the same instrument and under the same chromatographic conditions. Relative percentage amounts were calculated from the total area under the peaks by the software of the apparatus 14 . …”

Section: Extraction and Analysis Of Essential Oilsmentioning

confidence: 99%

Comparative Studies of Chemical Compostion, Antimicrobial and Antioxidant Activity of Essential Oil of Some Species from Genus Artemisia

Elsharkawy

Ed-Dra²,

Abdallah

2018

Journal of Natural Remedies

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Background and Objective: Some species from genus Artemisia were used in ancient medicine since Pharaonic civilization, most species of this genus are grown in arid or desert zones in Egypt. The present study aimed to evaluate and compare the chemical constituents, antimicrobial and antioxidant potential of the essential oils of three species of Artemisia (Artemisia sieberi, Artemisia judaica and Artemisia monosperma) grown in Egypt. Materials and Methods: Chemical constituent of the essential oils of these species were analysed by GC-MS, antibacterial activities were carried out using disc-diffusion test and antioxidant properties were investigated with Iron, Fe (III) to Fe (II) reduction and DPPH radical scavenging capacity. Results: The results of chemical analysis revealed similarity between the three species in 20 compounds, the major compounds identified in essential oils were verbenol, (7.5 % and 11.51%) in A. sieberi and A. monosperma, β-caryophyllene oxide (1.25 % -0.78%) and Methyl jasmonate (0.9 % and 1.21 %) in A. sieberi and A. judaica, respectively. While the major compound in A. judaica was Lilac alcohol C (9.6%) and camphor (4.5%). The antibacterial investigation exhibited significant and broad-spectrum antibacterial efficacy of A. monosperma and A. judaica against different strains of Gram-positive and Gram-negative bacteria. Whereas, A. sieberi showed higher antibacterial efficacy against the gram-positive bacteria but weak or no effect against the Gram-negative bacteria. The results of the antioxidant investigation showed that A. sieberi present the higher reduction capacity with an IC 50 of 0.17 ± 0.03g/L, followed by A. judaica with an IC 50 of 0.58 ± 0.04g/L and A. monosperma with an IC 50 of 6.35 ± 0.41g/L. However, the reducing capacity of ascorbic acid and quercetin were 0.091 ± 0.002g/L and 0.026 ± 0.002g/L respectively. Conclusion: The present study revealed that the essential oils of A. sieberi, A. judaica and A. monosperma possesses significant antioxidant and antibacterial activity, which attributed to the plenty of varied chemical compounds in these medicinal plants.

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Section: Extraction and Analysis Of Essential Oilsmentioning

confidence: 99%

Comparative Studies of Chemical Compostion, Antimicrobial and Antioxidant Activity of Essential Oil of Some Species from Genus Artemisia

Elsharkawy

Ed-Dra²,

Abdallah

2018

Journal of Natural Remedies

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“…In Pakistan limited data is available on the therapeutic uses of medicinal plants. Among these medicinal plants Alkanna tinctoria is under investigation as having several therapeutic uses [5]; however has not been documented for its anti-multi-drug resistant bacterial activity and phytochemicals content.…”

Section: Introductionmentioning

confidence: 99%

Alkanna tinctoria leaves extracts: a prospective remedy against multidrug resistant human pathogenic bacteria

Khan

Rahman

Qasim

et al. 2015

BMC Complement Altern Med

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BackgroundPlants are rich source of chemical compounds that are used to accomplish biological activity. Indigenously crude extracts of plants are widely used as herbal medicine for the treatment of infections by people of different ethnic groups. The present investigation was carried out to evaluate the biological potential of Alkanna tinctoria leaves extract from district Charsadda, Pakistan against multidrug resistant human pathogenic bacteria including Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus.MethodsAnti-multi-drug resistant bacterial activity of aqueous, chloroform, ethanol and hexane extracts of Alkanna tinctoria leaves were evaluated by well diffusion method. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of different extracts were determined. Moreover qualitative phytochemicals screening of the studied extracts was performed.ResultsAll four selected bacteria including A. baumannii, E. coli, P. aeruginosa and S. aureus were categorized as multi-drug resistant (MDR) as they were found to be resistant to 13, 10, 19 and 22 antibiotics belonging to different groups respectively. All the four extract showed potential activity against S. aureus as compare to positive control antibiotic (Imipenem). Similarly among the four extracts of Alkanna tinctoria leaves, aqueous extract showed best activity against A. baumannii (10 ± 03 mm), P. aeruginosa (12 ± 0.5 mm), and S. aureus (14 ± 0.5 mm) as compare to Imipenem. The MICs and MBCs results also showed quantitative concentration of plant extracts to inhibit or kill MDR bacteria. When phytochemicals analysis was performed it was observed that aqueous and ethanol extracts showed phytochemicals with large number as well as volume, especially Alkaloides, Flavonoides and Charbohydrates.ConclusionThe undertaken study demonstrated that all the four extracts of Alkanna tinctoria leaves exhibited considerable antibacterial activity against MDR isolates. Finding from the current study will be helpful for further elucidation of lead molecules from Alkanna tinctoria leaves for future therapeutic use against MDR pathogens.

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“…On the other hand, the reduction in the liver enzyme levels in the inflammatory condition at double dose is a pointer to possible hepatoprotective effect of the herbal preparation at high dose. Similar study on an herbal mixture containing three plants used as antiinflammatory agents among Bedouin people of Saudi Arabia was reported to possess significant anti-inflammatory activity 32 . Therapeutic benefits of traditional remedies are often attributed to a combination of active constituents 25 .…”

Section: Fig 2: Body Weight Of the Rats At Selected Days During Hb-0mentioning

confidence: 95%

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2018

IJPSR

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An herbal formulation composed of Allium cepa (Onion), Zingiber officinale (Ginger), Allium sativum (Garlic), Aloe vera, Andrographis paniculata (King of bitters), Allium ascalonicum (Shallot), reportedly used as anti-inflammatory agent was investigated. This study evaluated the physicochemical, phytochemical properties and in vivo anti-inflammatory effect of the herbal formulation. The herbal formulation (Hp-01) was subjected to physicochemical analysis; visual and organoleptic test, thin layer chromatography (TLC), pH, trace elements, phytochemical screening, antioxidant activity using DPPH inhibition and total phenolic acid (TPA) content determination. The biological effect at three doses (half, normal and double) on acute inflammation using carrageenan-induced paw oedema, weight, haematological parameters and liver functions were investigated in Wistar rats. The herbal formulation (Hp-01) was an acidic (pH 3.18), bitter preparation with pungent odour and sediments. The TLC analysis showed a maximum of three spots. Trace elements content of Pb, Cd, Fe, and Zn were within acceptable limits at 0.053, 0.003, 1.190 and 4.190 mg/l respectively. Phytochemical screening showed the presence of anthraquinones, tannins, terpenoids, saponins (2.12%w/w), alkaloids (2.45%w/w) and flavonoids (49.45%w/w). The IC 50 for DPPH radical scavenging activity was 2646.82±58.24 µg/ml indicating low activity, while TPA content was 0.0184±0.0005 mgGAE/g. The antiinflammatory activity of the herbal formulation was comparable acetylsalicylic acid (reference) at the three doses tested (p>0.05). Also, there was no significant effect on the weight, liver function, some haematological parameters; PCV, RBC, Hb. The herbal formulation has comparable anti-inflammatory activity with acetylsalicylic acid and may be explored for new anti-inflammatory agents.

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Anti-inflammatory effects of medicinal plants mixture used by Bedouin people in Saudi Arabia

Cited by 11 publications

References 25 publications

Comparative Studies of Chemical Compostion, Antimicrobial and Antioxidant Activity of Essential Oil of Some Species from Genus Artemisia

Comparative Studies of Chemical Compostion, Antimicrobial and Antioxidant Activity of Essential Oil of Some Species from Genus Artemisia

Alkanna tinctoria leaves extracts: a prospective remedy against multidrug resistant human pathogenic bacteria

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