Anti-inflammatory Effects of Melaleuca alternifolia Essential Oil on Human Polymorphonuclear Neutrophils and Monocytes

Caldefie-Chézet, Florence; Guerry, M; Chalchat, Jean‐Claude; Fusillier, C; Vasson, Marie‐Paule; Guillot, Jean

doi:10.1080/1071576042000220247

Cited by 63 publications

(45 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The water-soluble fraction of TTO, terpinen-4-ol, and ␣-terpineol also suppressed superoxide production by agonist-stimulated monocytes but not neutrophils (22). In contrast, similar work found that TTO decreases the production of reactive oxygen species by both stimulated neutrophils and monocytes and that it also stimulates the production of reactive oxygen species by nonprimed neutrophils and monocytes (29). TTO failed to suppress the adherence reaction of neutrophils induced by TNF-␣ stimulation (2) or the casein-induced recruitment of neutrophils into the peritoneal cavities of mice (1).…”

Section: Anti-inflammatory Activitymentioning

confidence: 65%

Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

2006

View full text Add to dashboard Cite

SUMMARY Complementary and alternative medicines such as tea tree (melaleuca) oil have become increasingly popular in recent decades. This essential oil has been used for almost 100 years in Australia but is now available worldwide both as neat oil and as an active component in an array of products. The primary uses of tea tree oil have historically capitalized on the antiseptic and anti-inflammatory actions of the oil. This review summarizes recent developments in our understanding of the antimicrobial and anti-inflammatory activities of the oil and its components, as well as clinical efficacy. Specific mechanisms of antimicrobial and anti-inflammatory action are reviewed, and the toxicity of the oil is briefly discussed.

show abstract

Section: Anti-inflammatory Activitymentioning

confidence: 65%

Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

2006

View full text Add to dashboard Cite

show abstract

“…The antimicrobial activity of melaleuca may be mediated by interaction with and disruption of bacterial plasma membranes (Cox et al, 2000). The antiinflammatory activity may be mediated by the suppression of reactive oxygen species in monocytes and neutrophils (Brand et al, 2001;Caldefie-Chezet et al, 2004;Hart et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

A clinical study: melaleuca, manuka, calendula and green tea mouth rinse

Lauten

Boyd²,

Hanson

et al. 2005

Phytother. Res.

View full text Add to dashboard Cite

A novel mouthrinse (IND 61,164) containing essential oils and extracts from four plant species (Melaleuca alternifolia, Leptospermum scoparium, Calendula officinalis and Camellia sinensis) were tested. This study aimed to evaluate the safety, palatability and preliminary efficacy of the rinse. Fifteen subjects completed the Phase I safety study. Seventeen subjects completed the Phase II randomized placebo-controlled study. Plaque was collected, gingival and plaque indices were recorded (baseline, 6 weeks, and 12 weeks). The relative abundance of two periodontal pathogens (Actinobacillus actinomycetemcomitans, Tanerella forsythensis) was determined utilizing digoxigenin-labeled DNA probes. ANCOVA was used at the p = 0.05 level of significance. Two subjects reported a minor adverse event. One subject withdrew from the study. Several subjects objected to the taste of the test rinse but continued treatment. Differences between gingival index, plaque index or relative abundance of either bacterial species did not reach statistical significance when comparing nine placebo subjects with eight test rinse subjects. Subjects exposed to the test rinse experienced no abnormal oral lesions, altered vital signs, changes in liver, kidney, or bone marrow function. Larger scale studies would be necessary to determine the efficacy and oral health benefits of the test rinse.

show abstract

“…The chemical composition of Melaleuca alternifolia EO was determined by gas chromatography (GC) performed as previously described (Caldefie-Chezet et al, 2004). The major components of this EO are listed in Table 1.…”

Section: Methodsmentioning

confidence: 99%

“…Among these, Hart et al (Hart et al, 2000;Brand et al, 2001) report that it can suppress proinflammatory mediator (interleukin (IL)-1, IL-8 and prostaglandin E2) production by activated human peripheral blood monocytes. It was previously determined that Melaleuca alternifolia EO may be both a direct activator of the bactericidal response of the circulating leukocytes and a protector from excess reactive oxygen species (ROS) via an antioxidant activity (Caldefie-Chezet et al, 2004). Indeed, the ROS produced by monocytes/macrophages and polymorphonuclear neutrophils (PMNs) during stress contribute to the host's system of defense against invading microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Potential anti‐inflammatory effects of Melaleuca alternifolia essential oil on human peripheral blood leukocytes

Caldefie-Chézet

Fusillier

Jardé

et al. 2006

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

The fungicidal and bactericidal actions of the essential oil (EO) of Melaleuca alternifolia seem well established, but their anti-inflammatory and antioxidative effects remain unclear. This study investigated in vitro the possible role of whole Melaleuca alternifolia EO as a modulator of the inflammatory/non-specific immune response by exploring the chemotaxis and kinetic radical oxygen species (ROS) production of leukocytes and cytokine secretion in peripheral blood mononuclear cells (PBMCs) in humans. The influence of Melaleuca alternifolia EO on the chemotaxis under agarose of isolated neutrophils (PMNs) was evaluated. The kinetics of ROS production by stimulated total circulating leukocytes was followed over 2 h by recording the fluorescence intensity of oxidized dihydrorhodamine 123. The effects of this EO on pro-(interleukin IL-2) and anti-(IL-4 and IL10) inflammatory cytokine secretions were determined by ELISA following incubation of PBMCs with the EO for 24 h. Melaleuca alternifolia EO was inefficient on the chemotaxis of PMNs. It exerted an antioxidant effect, reducing ROS production throughout the kinetic study. Melaleuca alternifolia EO inhibited PBMC proliferation, as revealed by a reduction in IL-2 secretion by stimulated lymphocytes. This EO at 0.1% directly increased the secretion of the anti-inflammatory cytokine IL-4 compared with IL-4 secretion without EO (18.5 +/- 10.0 vs 3.3 +/- 1, p < 0.05), and also increased IL-10 secretion at 0.01% (94.9 +/- 38.7 vs 44.1 +/- 18, ns). Melaleuca alternifolia EO may not only act as an anti-inflammatory mediator through its antioxidant activity but may also efficiently protect the organism by reducing the proliferation of inflammatory cells without affecting their capacity to secrete anti-inflammatory cytokines.

show abstract

Anti-inflammatory Effects of Melaleuca alternifolia Essential Oil on Human Polymorphonuclear Neutrophils and Monocytes

Abstract: M. alternifolia EO may be both a direct active mediator of the bactericidal action of the circulating leukocytes and may be efficient in protecting the organism from an excess of ROS, through an anti-oxidant and radical scavenging activity.

Cited by 63 publications

References 0 publications

Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

Melaleuca alternifolia(Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties

A clinical study: melaleuca, manuka, calendula and green tea mouth rinse

Potential anti‐inflammatory effects of Melaleuca alternifolia essential oil on human peripheral blood leukocytes

Contact Info

Product

Resources

About