Anti-inflammatory effects of Pelargonium endlicherianum Fenzl. extracts in lipopolysaccharide-stimulated macrophages.

Cumaoğlu, Ahmet; Karatoprak, Gökçe Şeker; Yerer, Mükerrem Betül; Koşar, Müberra

doi:10.4274/tjps.86580

Cited by 2 publications

(2 citation statements)

References 31 publications

(36 reference statements)

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“…[18][19][20]. Использование Умкалора в клинической практике обусловливают следующие доказанные эффекты препарата: антимикробный (антивирусный, антибактериальный, антимикотический и антипротозойный) [21][22][23][24][25], иммуномодулирующий [21,26,27], противовоспалительный [28], улучшение дренажной функции ВДП (муколитический, секретомоторный) [27].…”

Section: Bronchopulmonology Otorhinolaryngologyunclassified

Clinical and microbiological rationale for the use of a herbal preparation in children with rhinopharyngitis

et al. 2022

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Introduction. The work includes the results of clinical and microbiological studies that determine the feasibility of using the herbal preparation EPS® 7630 for the treatment of rhinopharyngitis (RF) in children. The introduction provides a brief review of the literature data on the role of the microbial factor and the important contribution of dysbiotic disorders of the URT microflora in the development of the Russian Federation. The porpose of persistent properties of opportunistic microorganisms (UPM) is outlined: the ability to biofilm formation – BPO and inactivation of lysozyme – ALA as dysbiotic markers of RF, which create conditions for relapses and chronicity of the disease, reduce the effectiveness of antimicrobial therapy. Goal.The aim of the work was the clinical and microbiological substantiation of the effectiveness of using EPS® 7630 in the treatment of RF in children.Materials and methods. The study involved 79 children aged 3 to 15 years. 1st group – 43 children who received treatment, including, along with traditional treatment, the drug Umckalor EPS® 7630, 2nd group (comparison) – 36 children who did not receive the tested drug. Microbiological examination was carried out by taking swabs from the pharynx and nose before and after treatment; BPO and ALA were determined according to the methods of Bukharin O.V. et al. (1999).Results. Conducted clinical studies have established a reduction in the timing of relief of the main symptoms of RF (cough, rhinitis, sore throat, fever) in children treated with EPS® 7630 compared to the comparison group. Microbiological studies of microorganisms isolated from the nasopharynx of children with RF revealed the ability of EPS® 7630 to suppress bacterial persistence factors (BPO and ALA) by 60% or more from the initial level.Conclusions. The data obtained reveal one of the mechanisms of the antimicrobial action of EPS® 7630, which consists in suppressing the persistent potential of UPM and regulating the effect of the drug on the microbiocenosis of the URT. The clinical and microbiological efficacy of using EPS® 7630 in the treatment of RF in children has been proven.

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Section: Bronchopulmonology Otorhinolaryngologyunclassified

Clinical and microbiological rationale for the use of a herbal preparation in children with rhinopharyngitis

et al. 2022

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“…It is also used for chronic headaches, neck pains, and migraines [14]. Studies have shown that P. quercetorum has a high content of total phenols and flavonoids, and gallic acid and apocynin have been identified in the root extracts of the plant [16]. Although there are limited studies on this traditionally used plant, it has been shown to cause apoptosis in lung and breast cancer cell lines.…”

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confidence: 99%

Appraisal of the antimicrobial and cytotoxic potentials of nanoparticles biosynthesized from the extracts of Pelargonium quercetorum Agnew

Dumlupınar

Karatoprak

Fırat

et al. 2021

Front. Biosci. (Landmark Ed)

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Aim:The aim of this study is the synthesis of nanosilver particles (AgNPs) from Pelargonium quercetorum Agnew. (Geraniaceae) and evaluation of the antimicrobial and the cytotoxic potential of AgNPs. Methods: The synthesized AgNPs were evaluated for antimicrobial and anticancer efficacy using the minimum inhibition concentration method and MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium bromide) assay. Results: The AgNPs inhibited approximately 90% the growth of grampositive Staphylococcus aureus and gram-negative Esh-erichia coli and yeast Candida albicans pathogens at a concentration of 500 µg/mL. The synthesized AgNPs showed excellent toxicity in MCF-7 cells, and specifically, pq70 AgNP inhibited the growth of MCF-7 cells by 52% at a concentration of 3.125 µg/mL. Conclusion: It was determined that the AgNPs, which had been synthesized from extracts that contained a high phenolic composition, were smaller in size, and showed high anticancer and antimicrobial properties.Abbreviations: pq11, 11% ethanol root extract of P. quercetorum; pq70, 70% methanol root extract of P. quercetorum; pqh, 70% methanol herba extract of P. quercetorum; AgNPs, Nanosilver particles; MTT, 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium bromide; SEM, Scanning electron microscopy; UV, Ultraviolet; pq11AgNP, Silver nanoparticles of 11% ethanol root extract of P. quercetorum; pq70AgNP, Silver nanoparticles of 70% methanol root extract of P. quercetorum; pqhAgNP, Silver nanoparticles of 70% methanol herba extract of P. quercetorum.

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Anti-inflammatory effects of Pelargonium endlicherianum Fenzl. extracts in lipopolysaccharide-stimulated macrophages.

Cited by 2 publications

References 31 publications

Clinical and microbiological rationale for the use of a herbal preparation in children with rhinopharyngitis

Clinical and microbiological rationale for the use of a herbal preparation in children with rhinopharyngitis

Appraisal of the antimicrobial and cytotoxic potentials of nanoparticles biosynthesized from the extracts of Pelargonium quercetorum Agnew

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