Anti-inflammatory effects of phenolic compounds isolated from the flowers of Nymphaea mexicana Zucc.

Hsu, Chin‐Lin; Fang, Song-Chwan; Yen, Gow‐Chin

doi:10.1039/c3fo60041f

Cited by 46 publications

(29 citation statements)

References 41 publications

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“…Hsu et al showed that naringenin extracted from Nymphaea mexicana Zucc. has an important inhibitory effect on MCP-1 and TNF-α production in LPS-activated RAW264.7 macrophages by decreasing the expression of iNOS and ERK phosphorylation [229]. The anti-inflammatory effects of naringenin in vivo were evaluated by Raza et al, demonstrating that naringenin treatment downregulates the NF-κB expression levels in the brains of Wistar rats after the cerebral I/R injury [230].…”

Section: Flavanolsmentioning

confidence: 99%

Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

et al. 2020

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Atherosclerosis is the main process behind cardiovascular diseases (CVD), maladies which continue to be responsible for up to 70% of death worldwide. Despite the ongoing development of new and potent drugs, their incomplete efficacy, partial intolerance and numerous side effects make the search for new alternatives worthwhile. The focus of the scientific world turned to the potential of natural active compounds to prevent and treat CVD. Essential for effective prevention or treatment based on phytochemicals is to know their mechanisms of action according to their bioavailability and dosage. The present review is focused on the latest data about phenolic compounds and aims to collect and correlate the reliable existing knowledge concerning their molecular mechanisms of action to counteract important risk factors that contribute to the initiation and development of atherosclerosis: dyslipidemia, and oxidative and inflammatory-stress. The selection of phenolic compounds was made to prove their multiple benefic effects and endorse them as CVD remedies, complementary to allopathic drugs. The review also highlights some aspects that still need clear scientific explanations and draws up some new molecular approaches to validate phenolic compounds for CVD complementary therapy in the near future.In the last decade the scientific researchers turned their attention to phytochemicals, as effective, safe and low-cost natural bioactive compounds for CVD treatment.Dyslipidemia consists of increased blood concentrations of total cholesterol (TC), low density lipoproteins-cholesterol (LDL-C) and/or triglycerides (TG), and decreased high density lipoproteins-cholesterol (HDL-C) [6]. The lipid metabolism is complex and the candidate mechanisms that could generate dyslipidemia include: (i) excessive dietary lipid absorption in the small intestine; (ii) packing of exogenous lipids with cholesterol and fatty acids produced de novo in the liver and their secretion as very low density lipoproteins (VLDL); (iii) hydrolysis of TG from VLDL by lipases and their conversion into LDL, which are taken up by the peripheral tissues through LDL receptor (LDL-R) and scavenger receptors; (iv) diminished production of HDL by the liver and small intestine, thereby decreasing reverse cholesterol transport (RCT) from the peripheral tissues to the liver; (v) lowered excess cholesterol excretion from the liver into gallbladder or to the intestinal lumen through the ATP-binding cassette G5 and G8 transporters (ABCG5/G8) that facilitate trans-intestinal cholesterol efflux (TICE). Dyslipidemia is associated with the accumulation of LDL in the sub-endothelium of the artery wall. At this site, LDL undergoes oxidative modifications (oxLDL) that trigger inflammatory responses, and is taken up by the monocyte-derived macrophages infiltrated in the sub-endothelium which thus become lipid-loaded foam cells, the hallmark of atheroma development [7]. Until now, the most effective lipid-lowering treatment for hyperlipidemic patients was the statin therapy. But recen...

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Section: Flavanolsmentioning

confidence: 99%

Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

et al. 2020

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“…Total phenolics and the antioxidant capacities of ten flowers were measured in China; the results indicated that flowers were good sources of phenolics and antioxidants (Xiong et al, 2014). Other researchers have also indicated that flowers are rich in phenolic compounds and have great antioxidant activity, as well as the capacity to inhibit some chronic diseases (Besbes et al, 2013;Hsu, Fang, & Yen, 2013;Lin, Chung, & Hsu, 2012). In previous studies, large amounts of organic solvents were used to extract antioxidants from flowers (Xiong et al, 2014); however organic solvents are unsafe to researchers and unfriendly to the environment.…”

Section: Introductionmentioning

confidence: 98%

Total phenolic, flavonoid and antioxidant activity of 23 edible flowers subjected to in vitro digestion

Chen¹,

Chen²,

Xie³

et al. 2015

Journal of Functional Foods

173

104

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“…4 d-galactose can also affect oxidative biomarkers, such as superoxide dismutase (SOD) and malondialdehyde (MDA) and change the total antioxidant status in the blood, brain, and liver. 5 Therefore, d-galactose-induced aging is often used as a model of aging. 6,7 Phenylethanoid glycosides (PeGs) are present in more than 150 species of plants belonging to 20 families and 77 genera.…”

Section: Introductionmentioning

confidence: 99%

Osmanthus fragrans Flower Extract and Acteoside Protect Against d-Galactose-Induced Aging in an ICR Mouse Model

Xiong

Mao

et al. 2016

Journal of Medicinal Food

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Osmanthus fragrans flower extract (OFE) is an organic extract from O. fragrans flower, which exhibits neuroprotective, free radical scavenging, and antioxidant effects. Therefore, the protective effect of OFE and acteoside against aging was studied. An aging ICR mouse model was established by chronically administering d-galactose (250 mg/kg) for 8 weeks. d-galactose induced spatial learning and memory impairments that were successfully inhibited by OFE and acteoside, which could shorten escape latency, improve platform crossing times, and increase zone time. The antioxidant potential of OFE and acteoside in vivo was evaluated by estimating the following: activities of antioxidant enzymes, such as glutathione peroxidase and aging-related enzyme, particularly monoamine oxidase; contents of lipid peroxidation methane dicarboxylic aldehyde, advanced glycation end products, and 8-hydroxy-2'-deoxyguanosine (a DNA damage product); and levels of nuclear factor-erythroid 2-related factor 2. OFE and acteoside also inhibited d-galactose-induced neurological aging by suppressing the increase in glial fibrillary acidic protein and neurotrophin-3. Considering the dose-dependent protective effects of OFE and acteoside, we concluded that OFE, rich in acteoside, was a good source of natural antiaging compounds.

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Anti-inflammatory effects of phenolic compounds isolated from the flowers of Nymphaea mexicana Zucc.

Cited by 46 publications

References 41 publications

Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

Total phenolic, flavonoid and antioxidant activity of 23 edible flowers subjected to in vitro digestion

Osmanthus fragrans Flower Extract and Acteoside Protect Against d-Galactose-Induced Aging in an ICR Mouse Model

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