Anti-inflammatory effects of Punica granatum Linne in vitro and in vivo

The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer

“…In vitro and in vivo antiinflammatory effects of Punica granatum Linne, a high phenolic content fruit, widely used as an antipyretic analgesic in Chinese culture, were investigated by Lee et al (2010). Pomegranate has shown potential nitric oxide (NO) inhibition in liposaccaharide (LPS)-induced RAW 264.7 macrophage cells, with significant decrease in carrageenan-induced mice paw edema.…”

“…Since ancient times, the pomegranate has been used extensively in the folk medicine of many cultures as a "healing food" in order to eliminate parasites, as an antihelmintic and vermifuge, antipyretic, and to treat and cure aphtae, ulcers, diarrhea, acidosis, dysentery, hemorrhage, microbial infections, and respiratory pathologies. It also features prominently in the ceremonies, art, and mythology of the Egyptians and Greeks, and was the personal emblem of Maximilian, the Holy Roman Emperor (Longtin, 2003;Larrosa et al, 2010;Lee et al, 2010).…”

Pomegranate (Punica Granatum L.) Peel Hydroalcoholic Extract Supplementation Reduces Pain and Improves Clinical Symptoms of Knee Osteoarthritis: A Randomized Double-Blind Placebo Controlled Study

“…Successful in vitro and in vivo assays indicated that pomegranate and its phenolic components are a very effective treatment against inflammatory disorders (12). Hopefully there are some findings suggesting that pomegranate peel extract stimulated type I procollagen synthesis and inhibited matrix metalloproteinase 1 (MMP-1) production by dermal fibroblasts, which are very important for cartilage damage and repairmen cycle in OA (13).…”

The Anti-Inflammatory Effects of Taif Punica Granatum in Cytokines Production in PBMCS of Patients With Rheumatoid Arthritis (Ra).

“…methanol and aqueous extracts from P. granatum peel could inhibit the expression and secretion of several inflammatory mediators such as IL-6, IL-8, MCP-1, iNOS, COX-2, and PGE 2 [28]. Additionally to these conclusions, there are some other studies that indicate P. granatum peel extracts might affect immune responses, for example a study of P. granatum contents exhibited inhibition of inducible nitric oxide synthase (iNOS) expression and NO production in in RAW 264.7 cells [29].…”