Anti-Inflammatory Effects of Resveratrol on Human Retinal Pigment Cells and a Myopia Animal Model

Hsu, Yu-Chin; Chen, Chin‐Sheng; Wang, Yao-Chien; Lin, En‐Shyh; Chang, Ching‐Yao; Chen, Jamie Jiin-Yi; Wu, Ming-Yen; Lin, Hui‐Ju; Wan, Lei

doi:10.3390/cimb43020052

Cited by 32 publications

(23 citation statements)

References 44 publications

(52 reference statements)

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“…Collagen disorders are exacerbated by the activation of the nuclear factor-κB, which increases the expression of matrix metalloproteinase 2 while reducing the activity of the tissue MMP2 inhibitor [ 120 ]. Hsu et al found shorter eyes in hamsters treated with RSV than in the group that had not been treated with RSV [ 121 ]. A decrease in resveratrol-treated eyes has been observed in myopia-related tissue remodeling proteins and the expression of inflammatory cytokines (NFκB, TGF-β, MMP2, TNFα, IL-6, and IL-1β).…”

Section: Resveratrol In Eye Diseasesmentioning

confidence: 99%

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The Role of Resveratrol in Eye Diseases—A Review of the Literature

et al. 2022

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Resveratrol (3,5,4′-trans-trihydroxystilbene) is a polyphenolic phytoalexin belonging to the stilbene family. It is commonly found in grape skins and seeds, as well as other plant-based foods. Oxidative stress and inflammation play a key role in the initiation and progression of age-related eye disorders (glaucoma, cataracts, diabetic retinopathy, and macular degeneration) that lead to a progressive loss of vision and blindness. Even though the way resveratrol affects the human body and the course of many diseases is still the subject of ongoing scientific research, it has been shown that the broad spectrum of anti-inflammatory and neuroprotective properties of resveratrol has a beneficial effect on eye tissues. In our research, we decided to analyze the current scientific literature on resveratrol, its possible mechanisms of action, and its therapeutic application in order to assess its effectiveness in eye diseases.

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Section: Resveratrol In Eye Diseasesmentioning

confidence: 99%

“…In addition, collagen I expression increase in eyes treated with resveratrol was noted. This might suggest that resveratrol exhibits a regulation pattern similar to atropine [ 121 ].…”

Section: Resveratrol In Eye Diseasesmentioning

confidence: 99%

The Role of Resveratrol in Eye Diseases—A Review of the Literature

et al. 2022

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“…Inflammatory cytokines IL-6 and TNF-α in the retina may serve as triggers to initiate MMP-2 activity in the retina, followed by sclera (Yuan et al 2019 ), causing progressive scleral remodeling and myopia. Moreover, resveratrol, a naturally occurring antioxidant, has been shown to ameliorate myopia development by blocking the relevant signaling pathways of inflammatory effects above (Hsu et al 2021 ; Jiang et al 2019 ; Wei et al 2019 ).…”

Section: Potential Biological Mechanisms Of Air Pollutants On Myopiamentioning

confidence: 99%

Effects of air pollution on myopia: an update on clinical evidence and biological mechanisms

Yuan

Zou

2022

Environ Sci Pollut Res

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Myopia is one of the most common forms of refractive eye disease and considered as a worldwide pandemic experienced by half of the global population by 2050. During the past several decades, myopia has become a leading cause of visual impairment, whereas several factors are believed to be associated with its occurrence and development. In terms of environmental factors, air pollution has gained more attention in recent years, as exposure to ambient air pollution seems to increase peripheral hyperopia defocus, affect the dopamine pathways, and cause retinal ischemia. In this review, we highlight epidemiological evidence and potential biological mechanisms that may link exposure to air pollutants to myopia. A thorough understanding of these mechanisms is a key for establishing and implementing targeting strategies. Regulatory efforts to control air pollution through effective policies and limit individual exposure to preventable risks are required in reducing this global public health burden.

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“…Proanthocyanidins and resveratrol enhance the expression of vascular endothelial growth factor (VEGF) in pigment cell culture [ 124 , 125 ] and animal model (hamsters) [ 126 ].…”

Section: The Beneficial Effects Of Polyphenols On Health and Its Mole...mentioning

confidence: 99%

The Utilization of Physiologically Active Molecular Components of Grape Seeds and Grape Marc

Hegedüs

Andreidesz

Szentpéteri

et al. 2022

IJMS

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Nutritional interventions may highly contribute to the maintenance or restoration of human health. Grapes (Vitis vinifera) are one of the oldest known beneficial nutritional components of the human diet. Their high polyphenol content has been proven to enhance human health beyond doubt in statistics-based public health studies, especially in the prevention of cardiovascular disease and cancer. The current review concentrates on presenting and classifying polyphenol bioactive molecules (resveratrol, quercetin, catechin/epicatechin, etc.) available in high quantities in Vitis vinifera grapes or their byproducts. The molecular pathways and cellular signaling cascades involved in the effects of these polyphenol molecules are also presented in this review, which summarizes currently available in vitro and in vivo experimental literature data on their biological activities mostly in easily accessible tabular form. New molecules for different therapeutic purposes can also be synthesized based on existing polyphenol compound classes available in high quantities in grape, wine, and grape marc. Therefore an overview of these molecular structures is provided. Novel possibilities as dendrimer nanobioconjugates are reviewed, too. Currently available in vitro and in vivo experimental literature data on polyphenol biological activities are presented in easily accessible tabular form. The scope of the review details the antidiabetic, anticarcinogenic, antiviral, vasoprotective, and neuroprotective roles of grape-origin flavonoids. The novelty of the study lies in the description of the processing of agricultural by-products (grape seeds and skins) of industrial relevance, and the detailed description of the molecular mechanisms of action. In addition, the review of the clinical therapeutic applications of polyphenols is unique as no summary study has yet been done.

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Anti-Inflammatory Effects of Resveratrol on Human Retinal Pigment Cells and a Myopia Animal Model

Cited by 32 publications

References 44 publications

The Role of Resveratrol in Eye Diseases—A Review of the Literature

The Role of Resveratrol in Eye Diseases—A Review of the Literature

Effects of air pollution on myopia: an update on clinical evidence and biological mechanisms

The Utilization of Physiologically Active Molecular Components of Grape Seeds and Grape Marc

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