Anti-inflammatory Effects of the Stem Barks from Albizia Ferruginea (Mimosaceae) on Chronic Inflammation Induced in Rats

B, Thierry; Kuum, Marc Germain Minoué; Guemmogne, Roméo Joël Temdie; Tchadji, Jules Colince; Lissom, Abel; Dimo, Théophile

doi:10.23958/ijirms/vol03-i09/423

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…This overproduction causes peroxidation of membrane lipids, which leads to tissue damage by damaging macromolecules. ROS cause or extend inflammation by stimulating the release of cytokines (IL-1beta, TNF-alpha, INF-alpha), which stimulate the recruitment of additional neutrophils and macrophages [18].…”

Section: Discussionmentioning

confidence: 99%

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The impact of imuheptin and imupurin on cytokine profile and antioxidant status in rat model of inflammation

Gutu,

Bacinschi,

Gudumac

2023

MJHS

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Introduction. Insects, throughout evolution, have developed a huge arsenal of active compounds, which they use to defend themselves against enemies and diseases, at the same time in recent years insects have shown great interest as a source of food rich in biologically active substances. Research in recent decades has shown that insects produce a variety of proteins and peptides with antibacterial, antifungal, antiviral, immunomodulatory, anti-inflammatory, antioxidant, antitumor, hepatoprotective, antithrombotic, antihypertensive and detoxifying activity during or after contact with the microbial agent or unfavourable factor. Material and methods. The anti-inflammatory effect of imuheptin and imupurin was investigated in a rat model of subacute inflammation induced by subcutaneous implantation of felt discs. The intensity of the exudative and proliferative phase of inflammation, cytokine profile (TNFalpha, IL-6, IL-10), ceruloplasmin and antioxidant enzymes (superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and glutathione-S-transferase) in the serum of rats were evaluated. Results. Imuheptin and imupurin reduced the level of pro-inflammatory cytokines (TNF-alpha, IL-6) and increased that of the anti-inflammatory cytokine (IL-10), as well as ceruloplasmin, glutathione reductase and glutathione peroxidase in subacute inflammation. Additionally, imupurin significantly increased the level of catalase and imuheptin that of glutathioneS-transferase. Conclusions. Imuheptin and imupurin determined a moderate effect of inhibiting the exudative and proliferative processes, compared to the reference preparation - dexamethasone, but with a favourable effect on the cytokine profile, decreasing the level of pro-inflammatory cytokines (TNF-alpha, IL-6) and increasing the level the anti-inflammatory one (IL-10), as well as the modulation of antioxidant enzyme activity.

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Section: Discussionmentioning

confidence: 99%

“…Imupurin showed a lower ability, compared to dexamethasone, to reduce the exudative and proliferative processes. Possibly, unlike the steroid anti-inflammatory, the preparation of entomological origin develops a slower effect due to its immunotropic properties on cellular immunity -modulation of T-lymphocytes [18,19].…”

Section: Discussionmentioning

confidence: 99%

The impact of imuheptin and imupurin on cytokine profile and antioxidant status in rat model of inflammation

Gutu,

Bacinschi,

Gudumac

2023

MJHS

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“…Secondary metabolites such as flavonoids [ 20 ], terpenoids, saponins, sterols, and tannins have been identified in Albizia species [ 18 ]. Although A. ferruginea has been reported for its antioxidant [ 21 ], anti-inflammatory [ 22 ], and antimicrobial activities [ 18 ], very little research have been carried out on its anthelminthic activities. The stem bark of A. ferruginea may have a promising anthelmintic activity due to its traditional usage as a purgative and a vermifuge [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Anthelmintic Activity of Ethanol Stem Bark Extract of Albizia ferruginea (Guill. & Perr.) Benth

Tagoe

Boakye

Agana

et al. 2021

Journal of Parasitology Research

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Albizia ferruginea (Guill. & Perr.) Benth bark is used in the traditional medicine as a vermifuge. This study sought to determine the anthelmintic activity of the stem bark extract of Albizia ferruginea. The powdered A. ferruginea stem bark was extracted with ethanol. Phytochemical screening was carried out on A. ferruginea ethanol extract (AFE) and then screened for its anthelmintic property against Pheretima posthuma and Haemonchus contortus using the adult motility assay. The effect of AFE and its fractions on the anthelminthic activity of mebendazole and albendazole were also determined using the adult worm (P. posthuma) motility assay. AFE showed a dose-dependent anthelmintic activity against P. posthuma and H. contortus. The least concentration of AFE (0.5 mg/mL) paralyzed and killed P. posthuma within 272.50 ± 12.42 min and 354.50 ± 5.06 min of exposure, respectively. AFE at the least test concentration (0.14 mg/mL) caused paralysis and induced death of H. contortus, after at 63.50 ± 2.98 and 254.96 ± 2.44 min of exposure, respectively. AFE extract at 0.25 and 0.125 mg/mL increased the paralytic and helminthicidal activities of albendazole. The paralytic and helminthicidal activities of mebendazole were reduced when combined with AFE (0.25 and 0.125 mg/mL). Among the three fractions obtained from AFE, the methanol fraction showed the highest anthelmintic activity. The methanol fraction at 0.5 mg/mL caused paralysis after 69.90 ± 0.15 min and death of worm after 92.53 ± 0.74 min of exposure. The petroleum ether and ethyl acetate fractions showed relatively low anthelmintic activity. Phytochemical screening of AFE revealed the presence of tannins, saponins, glycosides, alkaloids, and coumarins. The results from this study show that A. ferruginea possesses anthelmintic activity which gives credence to its folkloric use.

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Study of the Subacute Toxicity of Dry Bark of Albizia ferruginea (Mimosaceae) (Guill. &Perr.) Berth. in Wistar Albino Rats

Minoue Kuum,

Tchadji,

Ndji Otto

et al. 2022

J. Pharm. Med. Res.

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This present work aimed to assess the subacute toxicity of the total aqueous extract of the dry bark of Albizia ferruginea in rats. Subacute toxicity was done in accordance with 2008 OECD Guideline 407, for oral toxicity at a daily dose for 28 days in rodents. The animals were divided into six groups of 10 rats each (5 males and 5 females). One control group received 10 mL/kg of distilled water, three groups received 200, 400 and 800 mg/kg of extract respectively, one satellite control group and one satellite treated group received 10 mL/kg of distilled water and 800 mg/kg extract respectively. After 28 days of treatment, the satellite groups were left under observation without treatment for an additional 14 days. Behavior, body weight and death rate were monitored during the experimental period. The relative weight of some organs, hematological and biochemical parameters and the histopathological study of the liver, kidneys and lungs were evaluated at the end of the experiment. There were no significant effects on body weight gain and the relative weight of organs investigated. At the 800 mg/kg dose, there was a significant increase in the level of monocytes by 26.53%; the mean corpuscular hemoglobin content (MCHT) of 18.18%; and in the corpuscular hemoglobin concentration (MCHC) of 20.70 %, only in male rats. ALT and ASAT activity were increased significantly in both male and female rats. These increases were not seen in satellite treated rats. The histology of the organs investigated showed no difference when comparing the treated rats to the control rats. The subacute toxicity study of total aqueous extract of the dry bark of Albizia ferruginea did not show any signs of significant toxicity for parameters studied in rats.

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Anti-inflammatory Effects of the Stem Barks from Albizia Ferruginea (Mimosaceae) on Chronic Inflammation Induced in Rats

Cited by 3 publications

References 20 publications

The impact of imuheptin and imupurin on cytokine profile and antioxidant status in rat model of inflammation

The impact of imuheptin and imupurin on cytokine profile and antioxidant status in rat model of inflammation

In Vitro Anthelmintic Activity of Ethanol Stem Bark Extract of Albizia ferruginea (Guill. & Perr.) Benth

Study of the Subacute Toxicity of Dry Bark of Albizia ferruginea (Mimosaceae) (Guill. &Perr.) Berth. in Wistar Albino Rats

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