Anti-inflammatory effects of two lupane-type triterpenes from leaves of Acanthopanax gracilistylus on LPS-induced RAW264.7 macrophages

The anti-inflammatory activity of GABA-enriched Moringa oleifera leaves produced by fermentation with Lactobacillus plantarum LK-1

“…It has been reported that GABA suppressed the mRNA expression levels of key mediators in the NF-κB signaling pathway induced by LPS in MAC-T cells, such as TLR-4, myeloid differentiation 88 (MyD88), NF-κB p65 and TNF receptor-associated factor 6 (TRAF6), which indicated that GABA might suppresses inflammation by inhibiting the activity of the NF-κB signaling pathway ( 8 ). Furthermore, previous studies also showed that Moringa oleifera extract pretreatment could block LPS-induced activation of NF-κB p65 subunit in MAC-T cells and thus protect bovine mammary epithelial cells against inflammation ( 35 ). Several reports indicated that the high content of flavonoids and phenolic compounds contained in Moringa oleifera leaves contributed to its anti-inflammatory activity ( 15 , 44 , 45 ).…”

“…The free NF-κB transfers into the nucleus and turn on gene expression of pro-inflammatory mediators ( 33 , 34 ). In a word, TLR-4/NF-κB signaling pathway participates in the regulations of various inflammatory cytokines like IL-1β, IL-6, IL-8, and TNF-α, and plays an important role in both immune and inflammatory response ( 8 , 35 ). Interdicting the TLR/NF-κB signaling pathway will be an effective method for treatment of chronic inflammatory diseases.…”

Modulation of immune cum inflammatory pathway by earthworm granulation tissue extract in wound healing of diabetic rabbit model

“…In addition to this JAKs are cytoplasmic tyrosine kinases that could phosphorylate and dimerize the STATs, these dimerized entities are translocated to nucleus and bind with DNA which causes selective expression of genes responsible for immune activation. Contrarily to this addition of ergosta class of active principles results in transcriptional blockage of these genes and hence results in immune modulation [ 44 , 45 ].…”

Inhibition of LPS-induced expression of iNOS and COX-2 on extracts of Acanthopanax leucorrhizus (Oliv.) Harms stems

“…Jiang & Wang (2015) showed that A. senticosus EtOAc fraction exhibited stronger antioxidant effects and CH 2 Cl 2 fraction inhibited the mRNAs expression of iNOS, COX-2, TNF-α, and IL-6 and have antioxidant activity in macrophages (Jiang & Wang, 2015). Luo et al (2021a) reported the inhibitory effects of two lupane-type triterpenes from the leaves of A. gracilistylus on LPS-induced TNF-α, IL-1β, and the HMGB1 release in RAW264.7 macrophages (Luo et al, 2021a). Ahn et al (2018) investigated that Acanthopanacis cortexgold nanoparticles (A-AuNPs) suppressed NF-κB and AP-1 through phosphorylation of MAPKs signaling in RAW264.7 cells and inhibited the LPS-induced production of iNOS and COX-2 (Ahn et al, 2018).…”

“…This research provides evidence of the possible beneficial health advantages of A. leucorrhizus and furnished a reliable theoretical and practical basis for the developing and utilizing Acanthopanax species. symptoms of the inflammation, such as A. senticosus (Fei et al, 2014;Fan et al, 2019;Jin et al, 2020), A. gracilistylus (Liu et al, 2017;Zou et al, 2017;Xu et al, 2018;Luo et al, 2021a), and A. trifoliatus (Wang et al, 2015;Chien et al, 2015;Luo et al, 2021b), the mechanism of A. leucorrhizus stems on its antiinflammation activity is still not well known. For the purpose of developing and utilizing Acanthopanax species, we focused our study on the anti-inflammatory properties of various fractions of A. leucorrhizus stems through the effects on the production of NO, TNF-α, and IL-6, as well as on the expression of iNOS and COX-2 by LPS-induced RAW 264.7 macrophages.…”