Anti-inflammatory efficacy of Licochalcone A: correlation of clinical potency and in vitro effects

Kolbe, Ludger; Immeyer, Jeannine; Batzer, Jan; Wensorra, Ursula; Dieck, Karen Torn; Mundt, Claudia; Wolber, Rainer; Stäb, Franz; Schönrock, U.; Ceilley, Roger I.; Wenck, Horst

doi:10.1007/s00403-006-0654-4

Cited by 125 publications

(104 citation statements)

References 18 publications

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“…8 The anti-inflammatory and anti-oxidative properties of licochalcone A (8), present in the roots of Glycyrrhiza species have been described as effective to treat acne. 26,[29][30][31] Interestingly, Pueraria showed an equivalent number of patents and scientific articles. According to literature, Pueraria species have potential skin regenerative activity, however their bioactive compounds remain unknown.…”

Section: -25mentioning

confidence: 99%

Patent analysis: a look at the innovative nature of plant-based cosmetics

César¹,

Neto²,

Porto³

et al. 2017

Quim. Nova

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The use of plants have become a important trend in cosmetic market, with a crescent number of patent applications. Despite various herbal-based ingredients have been described in scientific literature, most of them are restricted to patent databases. In this work we analyze the innovative use of plants and its derivatives in cosmetic technologies, based on patent analysis. The investigation was conducted using Derwent World Patents Index (Thomson Reuters Scientific, USA) from 1995 to 2015. The search was carried out to evaluate the number of patent deposits, the patent depositors profiles, the countries with most patent applications, the International Patent Classification (IPC) and the main plant families using in cosmetics. Patent analysis revealed an increase number of applications involving cosmetic containing plants components, with a higher number of deposits related to anti-ageing and whitening skin treatment. Fabaceae, Asteraceae, Rosaceae, Lamiaceae, Poaceae, Rutaceae, Lilliacae and Apiaceae were the key plant families used in cosmetic formulations for skin care treatment. Comparison between scientific and technological data pointed out divergences between patents deposits and aid-based scientific reports. The use of patent analysis in combination with scientific data opens up wider aspects of knowledge and enables a better rationalization of innovative works.

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Section: -25mentioning

confidence: 99%

Patent analysis: a look at the innovative nature of plant-based cosmetics

César¹,

Neto²,

Porto³

et al. 2017

Quim. Nova

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“…The topical aqueous leave-on tonic (EUCERIN®-Dermo-Capillaire; Beiersdorf AG, Hamburg, Germany) comprised Glycyrrhiza inflata root extract which contained licochalcone A as active ingredient [17]. Further active ingredients were urea, polidocanol, and lactate (INCI: aqua, urea, methylpropanediol, sodium lactate, laureth-9, Glycyrrhiza inflata root extract, glycerin, lactic acid, arginine HCl, PEG-40 hydrogenated castor oil, cetrimonium chloride, phenoxyethanol).…”

Section: Methodsmentioning

confidence: 99%

“…With respect to human skin, licochalcone A exhibited anti-inflammatory activity in vitro and in vivo [16,17]. Topical treatments with formulations consisting of Glycyrrhiza inflata root extract, which contained licochalcone A, demonstrated beneficial effects on human skin in models of skin irritation [17] and in patients with erythematotelangiectatic rosacea and red facial skin [18]. Also, patients suffering from atopic dermatitis benefited from treatment with licochalcone A [19].…”

Section: Introductionmentioning

confidence: 99%

“…Licochalcone A exhibits anti-inflammatory and antimicrobial activity [12,13,14] and has been shown to suppress NF-κB-regulated gene products and inhibit tumor necrosis factor α (TNF-α)-induced inflammation [15]. With respect to human skin, licochalcone A exhibited anti-inflammatory activity in vitro and in vivo [16,17]. Topical treatments with formulations consisting of Glycyrrhiza inflata root extract, which contained licochalcone A, demonstrated beneficial effects on human skin in models of skin irritation [17] and in patients with erythematotelangiectatic rosacea and red facial skin [18].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of a New Tonic Containing Urea, Lactate, Polidocanol, and <b><i>Glycyrrhiza inflata</i></b> Root Extract in the Treatment of a Dry, Itchy, and Subclinically Inflamed Scalp

Schweiger

Baufeld

Drescher

et al. 2013

Skin Pharmacol Physiol

950

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Background/Aims: Dry, itchy and inflamed scalp conditions are common and often associated with diseases such as atopic dermatitis or psoriasis. To improve these symptoms, we investigated the efficacy of a new tonic containing the active ingredients urea, lactate, polidocanol, and Glycyrrhiza inflata root extract, containing licochalcone A. Study Design/Methods: 30 subjects with dry and itchy scalp conditions underwent a randomized half-head study for 4 weeks, applying the leave-on tonic three times a week on one side of the scalp. Tonic effects on skin hydration, itching, lipids, microinflammation, and substantivity of tonic compounds were determined using corneometry, middle-infrared spectroscopy, direct analysis in real-time mass spectrometry, and enzyme-linked immunosorbent assay. Volunteers performed a self-assessment; changes in scalp condition were documented by in vivo microscopy. Results: After tonic treatment, scalp moisture was significantly increased, whereas scalp itching and tautness were significantly reduced. Results also demonstrated a high substantivity of urea and lactate on the scalp, an increase in triglyceride, and a decrease in free fatty acid levels. The amount of total lipids was unchanged. Analyses of scalp wash-ups verified a significant reduction in important pro-inflammatory markers. Conclusion: Due to the actives urea, lactate, polidocanol, and the anti-inflammatory licochalcone A, the new scalp tonic exhibited excellent performance in alleviating scalp dryness, itching, microinflammation, and in normalizing disturbances of scalp lipids.

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“…Azelaic acid: Topical azelaic acid is an FDA approved treatment of rosacea and acne vulgaris and is useful for Acne -induced PIH 25 .…”

Section: Licochalcone a (Licorice Extract)mentioning

confidence: 99%

Untitled

2012

IJPSR

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Traditional remedies and preparation used for the treatment of skin, or the folk preparations used for healing skin diseases are known to be as Cosmeceuticals and cosmetics. The desire of gook looking and to be beautiful gave a huge market for the cosmetics. This is not a new tradition for human to look good; it has been a long ancient follow through for both the sexes to be presentable by beauty. For now, the desire of both the sexes to look younger than there age, to be fare and charming have directly increased the demand of herbal cosmetics as well as of the Cosmeceuticals in the market. The herbal formulations have been the first choice of the customers. For the reason of being less side effective and thought to be more potent than the synthetic formulations. There has been a long use of turmeric and sandalwood to be applied of face for fairness and freshness. As like many other herbs are used in daily life to be called as cosmetics and the preparation from them to be called as Cosmeceuticals. The above article is an effort to describe clearly both the terms and the relation between them.

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Anti-inflammatory efficacy of Licochalcone A: correlation of clinical potency and in vitro effects

Cited by 125 publications

References 18 publications

Patent analysis: a look at the innovative nature of plant-based cosmetics

Patent analysis: a look at the innovative nature of plant-based cosmetics

Efficacy of a New Tonic Containing Urea, Lactate, Polidocanol, and <b><i>Glycyrrhiza inflata</i></b> Root Extract in the Treatment of a Dry, Itchy, and Subclinically Inflamed Scalp

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