Anti-Inflammatory Efficacy of Topical Preparations with 10% Hamamelis Distillate in a UV Erythema Test

Abstract

In 40 volunteers the efficacy of three lotions with 10% hamamelis distillates from different suppliers, two vehicles, dimethindene maleate 0.1% gel, hydrocortisone 1% cream and hydrocortisone 0.25% lotion were investigated in a modified UV erythema test with three UV dosages (1.2, 1.4 and 1.7 MED). The test preparations were applied occlusively over a 48-hour period following irradiation. Chromametric measurement of redness and visual assessment were performed 24, 48 and 72 h after induction of erythema. The hydrocortisone formulations were most effective in erythema suppression. An anti- inflammatory effect was noted for all three hamamelis lotions as well as for the vehicles. A significantly greater suppression of erythema than seen with the vehicles was noted for one of the hamamelis lotions at 1.4 MED. The efficacy of the antihistamine dimethindene maleate did not surpass the hamamelis lotions or the vehicles. Even though the differences between the hamamelis lotions were slight, it was possible to make an objective selection of the best hamamelis distillate for aftersun purposes.

The UV Erythema Test as a Model to Investigate the Anti-Inflammatory Potency of Topical Preparations – Reevaluation and Optimization of the Method

“…As positive controls, different corticosteroids have been used, from 0.5% hydrocortisone to potent corticosteroids like 0.1% betamethasone [3-5, 8, 9] . Also the sample size varies from 5 to 40 subjects [1,3,4,10,11] . In recent studies, a trend towards larger sample sizes can be observed.…”

“…In recent studies, a trend towards larger sample sizes can be observed. Finally, different methods have been used to measure the erythema (visual scores, chromametric measurement) [1,4] .…”

The ‘Sparing Phenomenon' of Purpuric Rash over Tattooed Skin

“…One of the components of the patientʼs ink was H. virginiana, a kind of witch hazel that has been linked to anti-inflammatory properties, especially in cases of photodermatitis [37,38,39,40] and colonic cancer [41,42], due to a molecule called hamamelitannin, with anti-TNF properties (in vitro inhibition of TNF-mediated cell death and DNA fragmentation) [43] and scavenging activity against reactive oxygen species [42,44,45]. Even if it were attractive to assume that H. virginiana could have had an inhibitory effect over the purpuric rash, we would have to presume that functional levels of the active principle still remained in the skin 5 years after its injection, which is to be proven.…”

Ефективність Антигістамінних Препаратів I Покоління При Лікуванні Алергічних Захворювань У Дітей

“…По химической структу-ре диметиндена малеат представляет собой рацеми-ческую смесь, в которой один из энантиомеров, R(-) диметинден, обладает более мощным антигистамин-ным действием, способствуя снижению проницае-мости мелких сосудов и капилляров при аллергиче-ских реакциях немедленного типа. Препарат также является мощным стабилизатором мембран тучных клеток, что способствует опосредованному противо-воспалительному эффекту [10,17,29].…”