Anti-inflammatory furostanol saponins from the rhizomes of Smilax china L

Xie, Yunying; Hu, Deng; Zhong, Cheng; Liu, Kaifei; Fang, En; Zhang, Yingjun; Zhou, Chun; Tian, Liwen

doi:10.1016/j.steroids.2018.09.011

Cited by 19 publications

(17 citation statements)

References 15 publications

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“…This was further confirmed by the HMBC cross-peaks from H-21/H-24 to C-22 (Figure ). The aglycone of compound 1 was consistent with the 1 H- and 13 C NMR spectroscopic data reported in the literature . The vicinal coupling constants and NOESY correlations (Figure ) confirmed that 1 and AVE-A possessed the same relative configurations on their skeletal rings.…”

Section: Resultssupporting

confidence: 87%

“…Its 1 H- and 13 C NMR spectroscopic data (Supporting Information) were comparable to those of AVE-A . Both 1 and AVE-A have the same four sugar moieties, but the major difference between the two compounds was that the chemical shift of C-22 in 1 was found to be more shielded than that in AVE-A (δ C 114.1in 1 and 120.7 inAVE-A), which was almost identical to methyl proto-Pb reported in the literature (δ C 114.0), , indicating that 1 is the seco-22,25-avenacoside A. This was further confirmed by the HMBC cross-peaks from H-21/H-24 to C-22 (Figure ).…”

Section: Resultssupporting

confidence: 77%

“…The vicinal coupling constants and NOESY correlations (Figure ) confirmed that 1 and AVE-A possessed the same relative configurations on their skeletal rings. The side chain of the C-25 R configuration was determined based on the differences in chemical shifts of the geminal protons at H 2 -26 (δ b – δ a = 0.31 ppm < 0.48 ppm). , Thus, the structure of compound 1 was characterized, as shown in Figure , as a newly identified compound, named sativacoside A.…”

Section: Resultsmentioning

confidence: 99%

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Novel Steroidal Saponins in Oat Identified by Molecular Networking Analysis and Their Levels in Commercial Oat Products

Tang

Snooks

et al. 2021

J. Agric. Food Chem.

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Through the use of the Global Natural Product Social (GNPS) feature-based networking system, a series of newly identified steroidal saponins were discovered in oat. The structures of the three new major steroidal saponins, sativacosides A−C (1−3), were characterized by analyzing their high-resolution MS, 1D and 2D NMR spectra, and an additional eight new steroidal saponins were also tentatively identified (4−11) based on their tandem mass spectra and typical fragments. Using ultrahighperformance liquid chromatography with tandem mass spectrometry techniques, a complete profile of the new sativacoside series was established, and the contents of sativacosides A−C were quantified in 18 different commercial oat products. The total levels of sativacosides A−C varied from 62.2 to 192.9 μg/g in these 18 products, in which oat bran (11 samples) and oatmeal (3 samples) had higher levels than cold oat cereal (4 samples).

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Section: Resultssupporting

confidence: 87%

Section: Resultssupporting

confidence: 77%

Section: Resultsmentioning

confidence: 99%

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Novel Steroidal Saponins in Oat Identified by Molecular Networking Analysis and Their Levels in Commercial Oat Products

Tang

Snooks

et al. 2021

J. Agric. Food Chem.

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“…According to the concepts of Chinese Traditional Medicine, the herbal components have the following properties: Jinyinggen is acerb and neutral in nature, and is able to control nocturnal emission and astringent intestine (12). Baqia is bitter and neutral in nature; it is able to alleviate rheumatism, promote blood circulation, detoxicate, relieve convulsion and calm endogenous wind (13). Jinshateng is slightly sweet and cold-natured, and is able to clear heat, detoxicate and remove dampness (14).…”

Section: Introductionmentioning

confidence: 99%

Sanjin tablet combined with antibiotics for treating patients with acute lower urinary tract infections: A meta‑analysis and GRADE evidence profile

et al. 2019

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Numerous clinical studies have evaluated the performance of Sanjin tablets (SJTs) in the treatment of acute lower urinary tract infections (ALUTIs) in China. The present meta-analysis aimed to determine the efficacy and safety of SJT combined with antibiotics for the treatment of patients with ALUTIs and to evaluate the quality of evidence. The Cochrane Library, PubMed, EMBASE, Web of Science, Chinese BioMedical Database, China National Knowledge Infrastructure, WanFang and VIP databases were searched for entries added between inception and December 2018 to identify relevant randomized controlled trials (RCTs). The Cochrane risk-of-bias tool and Consolidated Standards of Reporting Trials for Traditional Chinese Medicine were used for assessing the methodological quality and reporting quality of eligible studies, respectively. Meta-analysis and quality of evidence assessment were performed with RevMan 5.3 and Grading of Recommendations, Assessment, Development and Evaluations (GRADE), respectively. A total of 8 RCTs comprising 790 patients with ALUTIs were included in the present meta-analysis. The cure rate of SJTs combined with gatifloxacin tablets (GTs) was higher than that of GTs alone [relative ratio (RR)=1.30, 95% CI=1.07–1.57, P=0.009]. The cure rate of SJTs combined with levofloxacin tablets (LTs) was higher than that of LTs alone (RR=1.13, 95% CI=1.04–1.24, P=0.006). SJTs combined with LTs was better in improving the total effective rate than LTs alone (RR=1.11, 95% CI=1.03–1.19, P=0.005). The recurrence rate for SJTs combined with antibiotics was lower than that associated with antibiotics alone (RR=0.35, 95% CI=0.13–0.97, P=0.04). The bacterial clearance rate achieved with SJTs combined with antibiotics was higher than that obtained with antibiotics alone (RR=1.41, 95% CI=1.09–1.84, P=0.009). The present meta-analysis demonstrated that, compared with the effects of antibiotics treatment, SJTs combined with antibiotics improved the cure rate, total effective rate and bacterial clearance rate, and decreased the recurrence rate. In addition, no serious adverse reactions were observed in patients with ALUTIs. However, the GRADE quality of evidence was low. Thus, further large-scale and rigorously designed clinical trials are required to improve the quality of evidence.

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“…In recent years, pharmacokinetic and metabolic studies of traditional Chinese medicine have attracted extensive attention and promoted in many regions (Ogbaji et al, 2018;Soleymani and Shahrajabian, 2018). The genus Smilax (Liliaceae family) comprises about 300 species of climbing flowering shrub (Xie et al, 2018). Some of the Smilax plant distributed in Asia area includes Taiwan, China, and Japan (Huang, 2000).…”

Section: Introductionmentioning

confidence: 99%

Tremendous health benefits and clinical aspects of Smilax china

Shahrajabian¹,

Sun²,

Cheng³

2019

Afr. J. Pharm. Pharmacol.

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A lot of species of Smilax known as Baqia in China are used in folk medicine for various purposes. Smilax china L., is a small vine that grows in the southern parts of China, known as Jin Gang Ten, which has a long history of indigenous use in China. S. china consists of fat, saponins, glucosides, gum, starch, flavonoids, tannins, and alkaloids. S. china has been used in traditional Chinese medicine because it has effective components such as triterpenoid, saponins, flavones, stilbenes, and organic acids. Roots are the most common used part; stems and rhizome can be used also in the form of powder or paste, raw or cooked. The most important health benefits of S. china are energy tonic, impotency and seminal disorders, chronic arthritis and secondary and tertiary syphilis, schizophrenia and epilepsy, pemphigus and skin diseases, ostero-arthritis, leucorrhea or white discharge, relieving joints numbness, diabetes and excretory system. The obtained findings strongly suggest potential of S. china as an additive in pharmaceutical industries.

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Anti-inflammatory furostanol saponins from the rhizomes of Smilax china L

Cited by 19 publications

References 15 publications

Novel Steroidal Saponins in Oat Identified by Molecular Networking Analysis and Their Levels in Commercial Oat Products

Novel Steroidal Saponins in Oat Identified by Molecular Networking Analysis and Their Levels in Commercial Oat Products

Sanjin tablet combined with antibiotics for treating patients with acute lower urinary tract infections: A meta‑analysis and GRADE evidence profile

Tremendous health benefits and clinical aspects of Smilax china

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