Anti-inflammatory kaurane diterpenoids of Erythroxylum bezerrae

Brito, Luana San de O.; Batista, Alison; Santos, Flávia Almeida; Lima, Renan Pereira de; Ayala, A. P.; Canuto, Kirley Marques; Silveira, Edilberto R.; Pessoa, Otília Deusdênia Loiola

doi:10.1016/j.fitote.2022.105424

Cited by 4 publications

(1 citation statement)

References 36 publications

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“…Many reports highlight the anti‐inflammatory activity of compounds, such as alkaloids [23] and diterpenoids, [24] from species of the genus Erythroxylum . However, the availability of data on other secondary metabolites isolated from this genus, especially when investigating the species E. bezerrae , remains limited, making research even more challenging.…”

Section: Resultsmentioning

confidence: 99%

Neuromodulation of Acid‐Sensitive Ion Channels (ASICs) and Anti‐Inflammatory Potential by Lichenxanthone in Adult Zebrafish (Danio rerio): Experimental and Docking Studies

Ribeiro Liberato,

Bezerra Maciel,

Wlisses Da Silva

et al. 2024

Chemistry & Biodiversity

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The xanthone Lichenxanthone did not show toxic effects (LC50 > 1.0 mg/mL). Lichenxanthone prevented nociceptive behavior induced by acidic saline, and its analgesic effect was blocked by amiloride, highlighting the involvement of neuromodulation of acid‐sensitive ion channels (ASICs). In the analysis of anti‐inflammatory activity, concentrations of 0.1 and 0.5 mg/mL of Lichenxanthone reduced the edema induced by k‐carrageenan 3.5%, observed from the fourth hour of analysis. This effect was similar to that observed with ibuprofen (positive control). No leukocyte infiltrates were observed in Lichenxanthone, suggesting that the compound acts in the acute inflammatory response. The results of the molecular docking study revealed that Lichenxanthone exhibited better affinity energy when compared to the ibuprofen control against the two targets evaluated.

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Section: Resultsmentioning

confidence: 99%