Anti-inflammatory mouthwashes for the prevention of oral mucositis in cancer therapy: an integrative review and meta-analysis

Thornton, Clifton P.; Li, Mengchi; Budhathoki, Chakra; Yeh, Chao Hsing; Ruble, Kathy

doi:10.1007/s00520-022-07068-5

Cited by 6 publications

(3 citation statements)

References 54 publications

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“…Presently, the utilization of mouthwashes that incorporate corticosteroids and nonsteroidal anti-inflammatory medications has proven to be efficacious in the prevention or mitigation of mucositis linked to cancer treatment [ 57 , 58 ]. Direct and indirect anti-inflammatory features have been noted in some mouthwashes and toothpaste containing compounds such as chlorhexidine, cetylpyridinium chloride, or stannous fluoride, which are utilized in controlling gingivitis, supragingival plaque formation, and periodontal disease development [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Ceragenins in Controlling the Growth of Oral Microorganisms: Implications for Oral Hygiene Management

Czarnowski,

Słowińska,

Sawieljew

et al. 2024

Pharmaceuticals

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Ensuring proper dental hygiene is of paramount importance for individuals’ general well-being, particularly for patients receiving medical care. There is a prevailing utilization of conventional oral hygiene items, including toothbrushes and mouthwashes, which have gained widespread acceptance; nevertheless, their limitations encourage investigating novel options in this domain. Our study indicates that ceragenins (CSAs) being lipid analogs of host defense peptides, well-recognized for their wide-ranging antimicrobial properties, may be a potentially efficacious means to augment oral hygiene in hospitalized individuals. We demonstrate that ceragenins CSA-13, CSA-44, and CSA-131 as well as undescribed to date CSA-255 display potent antimicrobial activities against isolates of fungi, aerobic, and anaerobic bacteria from Candida, Streptococcus, Enterococcus, and Bacteroides species, which are well-recognized representatives of microbes found in the oral cavity. These effects were further confirmed against mono- and dual-species fungal and bacterial biofilms. While the ceragenins showed similar or slightly diminished efficacy compared to commercially available mouthwashes, they demonstrated a highly favorable toxicity profile toward host cells, that may translate into better maintenance of host mucosal membrane stability. This suggests that incorporating ceragenins into oral hygiene products could be a valuable strategy for reducing the risk of both oral cavity-localized and secondary systemic infections and for improving the overall health outcomes of individuals receiving medical treatment.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Ceragenins in Controlling the Growth of Oral Microorganisms: Implications for Oral Hygiene Management

Czarnowski,

Słowińska,

Sawieljew

et al. 2024

Pharmaceuticals

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“…To address this, mouthwashes have been formulated to include anti-inflammatory agents such as steroids or non-steroidal anti-inflammatory drugs (NSAIDs). These mouthwashes help reduce gingival inflammation and promote healing in individuals with periodontal disease [18,19].…”

Section: Anti-inflammatory Mouthwashesmentioning

confidence: 99%

Advanced Approaches in the Treatment of Periodontal Disease: Enhancing Dentifrices and Mouthwashes for Improved Efficacy

Jihad

2024

OJDOH

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“…The anti-inflammatory and analgesic effect of benzydamine have been acknowledged in the literature, with preclinical and clinical studies proving this action even after topical application, as shown in Tables 2 and 3. Reduction in the number of inflammatory complications (patients with fractures of the alveolar processes of the jaws) [22] In addition to these studies, there are also numerous systematic reviews in the literature that confirm the effectiveness of benzydamine in the management of oral mucositis after cancer therapy [23][24][25][26][27], sore throat after intubation [28] or pericoronitis [29].…”

Section: The Therapeutic Effects Of Benzydaminementioning

confidence: 99%

Benzydamine—An Affordable Over-the-Counter Drug with Psychoactive Properties—From Chemical Structure to Possible Pharmacological Properties

et al. 2023

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Benzydamine is a non-steroidal anti-inflammatory drug with distinct pharmacological properties from other compounds in the same therapeutic class. The differences are structural and pharmacological in nature; the anti-inflammatory mechanism is not strictly explained by the ability to interfere with the synthesis of prostaglandins. The compound is used strictly in local inflammatory diseases (inflammation in the oral and vaginal mucosa). In addition to the therapeutic indications found in the summary of product characteristics (SPC), the compound is used, in high doses, as a psychotropic substance for oral administration, having similar properties to lysergic acid diethylamide (LSD). As an over-the-counter (OTC) compound, it is easy to obtain, and the consequences of using it for purposes other than those assumed by the manufacturer raise various concerns. The reasons are related to the pharmacodynamic and pharmaco-toxicological properties, since neither the mechanism of action nor the possible side effects that would result from systemic consumption, in high doses, even occasionally, have been fully elucidated. The present review aims to analyze the pharmacodynamic properties of benzydamine, starting from the chemical structure, by comparison with structurally similar compounds registered in therapy (as an anti-inflammatory or analgesic) or used for recreational purposes.

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Anti-inflammatory mouthwashes for the prevention of oral mucositis in cancer therapy: an integrative review and meta-analysis

Cited by 6 publications

References 54 publications

Efficacy of Ceragenins in Controlling the Growth of Oral Microorganisms: Implications for Oral Hygiene Management

Efficacy of Ceragenins in Controlling the Growth of Oral Microorganisms: Implications for Oral Hygiene Management

Advanced Approaches in the Treatment of Periodontal Disease: Enhancing Dentifrices and Mouthwashes for Improved Efficacy

Benzydamine—An Affordable Over-the-Counter Drug with Psychoactive Properties—From Chemical Structure to Possible Pharmacological Properties

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