2013
DOI: 10.1016/j.phytochem.2013.08.008
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Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum

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Cited by 88 publications
(54 citation statements)
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“…Measurement of the production of NO, IL-1β and IL-6 in cell culture supernatant Culture media were collected for NO, IL-1β and IL-6 assays. NO was measured by detection of its stable oxidative metabolite, nitrite, as previously described (Lin et al, 2013a). In brief, 50 μl of the culture media was mixed with an equal volume of Griess reagent (Beyotime) and incubated for 30 min at 37°C.…”
Section: Animalsmentioning
confidence: 99%
“…Measurement of the production of NO, IL-1β and IL-6 in cell culture supernatant Culture media were collected for NO, IL-1β and IL-6 assays. NO was measured by detection of its stable oxidative metabolite, nitrite, as previously described (Lin et al, 2013a). In brief, 50 μl of the culture media was mixed with an equal volume of Griess reagent (Beyotime) and incubated for 30 min at 37°C.…”
Section: Animalsmentioning
confidence: 99%
“…Nitric oxide was measured as described previously (Lin et al, 2013). The RAW264.7 cells were plated at 5 Â 10 5 cells/ml in 24-well plates, incubated overnight, and treated with different concentrations of test compounds for 1 h, followed by treatment with LPS (1 μg/ml) for an additional 24 h. NO measurements were conducted directly in the cell culture medium by using a commercially available kit based on the Griess reaction (Beyotime).…”
Section: Nitric Oxide Determinationmentioning
confidence: 99%
“…In our previous study, some phenanthrene derivatives isolated from Dendrobium denneanum exert were shown to exert their anti-inflammatory activity by inhibiting MAPK and NF-jB pathways. 11 In the present study, we further evaluated a group of synthesized phenanthrene analogs ( Fig. 1) to determine their structure-activity relationship with respect to their anti-inflammatory effects, and the purity and structural assignments of these Table 1, compounds 10, 11 and 17 were found to most potently inhibit the NO production induced by LPS without affecting the viability of RAW264.7 cells and the half maximal inhibitory concentrations (IC 50 ) of these three compounds were 37.26 lM, 5.05 lM and 20.31 lM, respectively (Fig.…”
mentioning
confidence: 99%
“…Previously we found that the natural phenanthrene derivatives with anti-inflammatory effect were found to inhibit the NF-jB pathway and JNK and p38 MAPK pathways. 11 Another three similar phenanthrene derivatives from Dendrobium nobile also exert the anti-inflammatory effects by inhibiting NF-jB pathway and ERK, JNK and p38 MAPK pathways. 5 Phenanthrene-based tylophorine-1 could inhibit the lung cancer cell growth by suppressing the NF-jB pathway and Akt phosphorylation.…”
mentioning
confidence: 99%
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