“…In our previous study, some phenanthrene derivatives isolated from Dendrobium denneanum exert were shown to exert their anti-inflammatory activity by inhibiting MAPK and NF-jB pathways. 11 In the present study, we further evaluated a group of synthesized phenanthrene analogs ( Fig. 1) to determine their structure-activity relationship with respect to their anti-inflammatory effects, and the purity and structural assignments of these Table 1, compounds 10, 11 and 17 were found to most potently inhibit the NO production induced by LPS without affecting the viability of RAW264.7 cells and the half maximal inhibitory concentrations (IC 50 ) of these three compounds were 37.26 lM, 5.05 lM and 20.31 lM, respectively (Fig.…”