Anti-inflammatory potential of a heat-killed<i>Lactobacillus</i>strain isolated from Kimchi on house dust mite-induced atopic dermatitis in NC/Nga mice

Choi, C.-Y.; Kim, Y.-H.; Oh, Sejong; Lee, H.J.; Kim, J.H.; Park, S.H.; Kim, H.J.; Lee, S.J.; Chun, Taehoon

doi:10.1111/jam.13515

Cited by 24 publications

(12 citation statements)

References 21 publications

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“…First, these organisms can increase the innate immune response, activate macrophages, and treat pathogenic bacteria by producing reactive oxygen species and lysosomes. Lactic acid bacteria can also activate the acquired immune system, activate B cells to secrete antibodies, and participate in body fluid immunity (Choi et al, 2017). In the early stage, we detected the surface hydrophobicity and adhesion of nine strains of lactic acid bacteria in vitro by BATH method, microscopic examination, plating method, and fluorescent labelling method and screened out two high-viscosity strains of L. salivarius and L. plantarum (Ren et al, 2014(Ren et al, , 2012.…”

Section: Discussionmentioning

confidence: 99%

Two strains of probiotic Lactobacillus enhance immune response and promote naive T cell polarization to Th1

Ren

Wang

Liu

et al. 2019

Food and Agricultural Immunology

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We co-cultured Caco-2 cells with Lactobacillus salivarius and L. plantarum in vitro to investigate their immunoregulatory mechanisms and detected Lactobacillus strains adhering to Caco-2 cells expressing mRNAs of cytokines and Toll-like receptors (TLRs) by fluorescent quantitative reverse transcription-polymerase chain reaction. The strains were intragastrically administered to mice. Thymus/spleen indexes were measured on different days. 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay, flow cytometry, and enzyme-linked immunosorbent assay were performed to assess different variables. Results showed increased mRNA expressions of T helper 1 (Th1), various cytokines, surface receptors, TLRs (2, 4, and 9), thymus/spleen indexes, spleen lymphocyte transformation rate, macrophage energy metabolism and phagocytosis, CD11c + CD80 + cell number, interferon-γ secretion, and sIgA secretion levels; inhibition of nuclear factor-κB inflammation signal pathway; and downregulated mRNA expression of specific interleukins. Both Lactobacillus strains can promote naive T cell differentiation (Th1) and participate in immunomodulatory responses, featuring a potential in prevention and management approaches for foodborne diseases. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Two strains of probiotic Lactobacillus enhance immune response and promote naive T cell polarization to Th1

Ren

Wang

Liu

et al. 2019

Food and Agricultural Immunology

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“…Comparably, mouse eosinophils were found to take up the probiotic Lactobacillus reuteri . Using various mouse models of asthma and AD, probiotics like Lactobacillus fermentum and L rhamnosus were found to improve allergic inflammation associated with decreased eosinophil infiltration, although a direct effect of probiotic bacterial strains on eosinophils was not demonstrated in these studies …”

Section: Microbiota Regulating Cellular Players In Innate and Adaptivmentioning

confidence: 92%

“…Mouse treatment with SCFA results in the recruitment of bone marrow‐derived DC with impaired capacity to induce Th2 responses in the lung . Probiotics administered by gavage reduce the severity of allergic airway inflammation and AD through the reduction of eosinophil infiltration into the lung and skin, respectively…”

Section: Translational Implications Of Microbiotamentioning

confidence: 99%

AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper

Untersmayr

Bax

Bergmann³

et al. 2019

Allergy

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The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti‐ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune‐related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.

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“…Live bacteria present preventive and therapeutic effects on AD lesions, and heat-killed probiotic cells were also reported to alleviate allergic responses in animal models [23]. For example, oral administration of heat-killed Lactobacillus brevis ameliorated the symptoms of dust miteinduced AD in NC/Nga mice by enhancing Th1-prone immunity [24]. Investigations on Lactobacillus rhamnosus GG revealed that intracellular or cell wall components of LGG, such as lipoteichoic acid, exopolysaccharides, and hydrolytic peptidoglycan, potentially cause immunomodulatory effects [25].…”

Section: Ns8 Attenuates Systemic Immune Responsesmentioning

confidence: 99%

Oral Intake of Lactobacillus helveticus NS8 Alleviates Ovalbumin-Induced Atopic Dermatitis in SKH-1 Hairless Mice

Rong

Liu

et al. 2018

Indian J Microbiol

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Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and is driven by strong type 2 immune responses. NS8 (NS8), a probiotic strain isolated from Mongolian koumiss, has anti-inflammatory activities. Here, we evaluated the therapeutic potential of NS8 on AD-like skin lesions by using SKH-1 hairless mice that underwent three cycles of epicutaneous sensitization (EC) with ovalbumin (OVA). NS8 (5 × 10 CFU/day) was orally administered to mice from 2 weeks before the first sensitization until the end of the study. NS8 attenuated the symptoms and pathological changes in the skin of AD mice. For example, NS8 reduced epidermal and dermal thickening and significantly restrained the infiltration of mast cells, eosinophils, and CD4 T cells into the dermis. By analysing the Th1/Th2 cytokines produced in skin lesions, we found that NS8 significantly suppressed the expression of IL-4, IL-5, and IL-13 ( < 0.05), while it had no discernible effect on the expression of IFN-γ. Systemically, NS-8 reduced the total IgE and OVA-specific IgE levels in serum ( < 0.05). Our study demonstrates that oral administration of . NS8 effectively alleviates AD severity in mice by suppressing the Th2 immune response. NS8 may be a promising candidate for prophylactic and therapeutic treatments of allergic diseases, such as AD.

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Anti-inflammatory potential of a heat-killedLactobacillusstrain isolated from Kimchi on house dust mite-induced atopic dermatitis in NC/Nga mice

Abstract: The immunomodulatory function of L. brevis NS1401 may provide effective new therapeutics against AD.

Cited by 24 publications

References 21 publications

Two strains of probiotic Lactobacillus enhance immune response and promote naive T cell polarization to Th1

Two strains of probiotic Lactobacillus enhance immune response and promote naive T cell polarization to Th1

AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper

Oral Intake of Lactobacillus helveticus NS8 Alleviates Ovalbumin-Induced Atopic Dermatitis in SKH-1 Hairless Mice

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