Anti-inflammatory potential of Lactiplantibacillus plantarum IDCC 3501 and its safety evaluation

Yang, Seun-Ah; Chae, Seung A; Bang, Won Yeong; Lee, Minjee; Ban, O‐Hyun; Kim, Soojung; Jung, Young Hoon; Yang, Jungwoo

doi:10.1007/s42770-021-00603-2

Cited by 19 publications

(20 citation statements)

References 31 publications

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“…Lactiplantibacillus plantarum ( L. plantarum ), a gram-like facultative anaerobe, is a kind of Generally Recognized as Safe (GRAS) [ 2 ]. It was commonly found in handmade fermented foods for a long history of human consumption and was always applicated in food preservation and probiotic usage [ 5 ]. As one of the important probiotics of human gut microbiota, L. plantarum , like others with various physiological functions, also exhibits superior efficacy in antibacterial and binding of various toxins [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Safety Assessment of One Lactiplantibacillus plantarum Isolated from the Traditional Chinese Fermented Vegetables—Jiangshui

Ling

Wang

et al. 2022

Foods

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Lactiplantibacillus plantarum is a kind of extensively utilized probiotic species, which plays a critical role in the prevention of pathogenic bacteria and development of functional probiotics. Our group previously isolated one Lactiplantibacillus from Jiang Shui, a traditional Chinese fermented vegetable, which remarkably inhibited the growth of Aspergillus flavus. Herein, the safety of this isolate was assessed to ensure its application feasibility in food industry. Firstly, the phenotypic analyses including tolerance to low pH and bile salt, aggregation ability, and hemolytic activity detection, indicated the isolate could survive and colonize in the gastrointestinal tract, without hemolysin activity. The susceptibilities of the isolate to eight antibiotics and the absence of most resistance genes were demonstrated by agar disk diffusion and PCR, respectively. Furthermore, no mortality or toxicity was observed in mice by in vivo tests using gross autopsy, hematology, serum biochemistry, and HE-staining. Taken together, this study demonstrated the safety of Lactiplantibacillus plantarum WYH as a probiotic strain in terms of phenotypic analyses, absence of antimicrobial resistance and toxin-related genes, as well as mice toxicity test, while supported the prospect of applying isolate in suppression of fungal growth and mycotoxin biosynthesis.

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Section: Introductionmentioning

confidence: 99%

Safety Assessment of One Lactiplantibacillus plantarum Isolated from the Traditional Chinese Fermented Vegetables—Jiangshui

Ling

Wang

et al. 2022

Foods

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“…Lactobacillus rhamnosus GG (LGG) was used as positive control primarily in probiotics study. Yang et al reported that NO inhibition rate of LGG was 37% [29]. Our LAB strains showed higher efficacy compared with LGG with a NO inhibition rate of 38 to 69%.…”

Section: Discussionmentioning

confidence: 53%

“…Recently, much attention has been paid to CFS containing biologically active metabolites secreted by living bacteria [29]. Moreover, unlike CFS, which contain only extracellular metabolites, probiotics may be more effective in improving health through a broader range of mechanisms [30].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Activity and Probiotic Properties of Lactic Acid Bacteria

Kim¹,

Lee²,

Jeong³

et al. 2022

Fermentation

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Oxidative stress, which can cause imbalance in the body by damaging cells and tissues, arises from the immoderate production of reactive oxygen species (ROS)/reactive nitrogen species (RNS). Therefore, external supplements having antioxidant activity are required for reducing oxidative stress. In our study, we investigated DPPH and ABTS radical scavenging ability, and the inhibition effect on the nitric oxide (NO) production of 15 food-derived bacterial strains in LPS-activated RAW264.7 cells. Among these LAB strains, eight strains with an excellent inhibition effect on NO production were selected through comparisons within the same genera. Moreover, the selected strains, including Leuconostoc mesenteroides MG860, Leu. citreum MG210, Pediococcus acidilactici MG5001, P. pentosaceus MG5078, Weissella cibaria MG5090, Levilactobacillus brevis MG5306, Latilactobacillus curvatus MG5020, and Latilactobacillus sakei MG5048 diminished the inducible nitric oxide synthase (iNOS)/cyclooxygenase-2 (COX-2) expression. In addition, the stability and adhesion ability of the eight LAB strains in the gastrointestinal tract were determined. In conclusion, the selected strains have potential as new probiotics with antioxidant effects.

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“…Thus, the resistance against kanamycin and streptomycin seems to be an intrinsic trait of this strain. Indeed, several studies have shown that several Lactobacillus species, including some commercially used strains, exhibit relative resistance to aminoglycoside antibiotics, such as gentamicin, kanamycin, and streptomycin [ 17 , 23 , 24 ]. As a result, L. fermentum KGC1601 can be considered safe in terms of antibiotic resistance.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, relative to any other function, the anti-inflammatory effect of probiotics toward improving intestinal health has been continuously studied for a long time. For example, L actobacillus plantarum IDCC 3501 isolated from kimchi exhibited the anti-inflammatory effect through the deregulation of genes associated with pro-inflammatory mediators and cytokines in macrophage cells [ 17 ]. In another study, several strains isolated from canine and feline feces were demonstrated to modulate anti-inflammatory activity through the inhibition of iNOS and COX-2 expression [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects of Limosilactobacillus fermentum KGC1601 Isolated from Panax ginseng and Its Probiotic Characteristics

Kim

Lee

et al. 2022

Foods

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We investigated the potential probiotic properties of Limosilactobacillus fermentum KGC1601 isolated from Panax ginseng. Ginseng cultivated in an experimental field of the Korea Ginseng Research Institute was fermented, followed by single colony selection from MRS agar. We performed 16s-rRNA sequencing and whole-genome analysis to identify L. fermentum and evaluate the biosafety parameters of this strain, respectively. We confirmed this strain was susceptible to six antibiotics, as proposed by the European Food Safety Authority, did not produce biogenic amines, and did not exhibit any hemolytic activity. Acid resistance and bile salt tolerance, which are essential properties of a probiotic agent, were investigated. Notably, distinguishing properties of this strain were that it exhibited excellent bile salt tolerance and anti-inflammatory effects. The excellent bile salt tolerance was confirmed by scanning electron microscopy. Through qRT-PCR and ELISA studies, it was revealed that L. fermentum KGC1601 pre-treatment up-regulates anti-inflammatory cytokines and down-regulates pro-inflammatory cytokines in RAW 264.7 cells. Consequently, we suggested that L. fermentum KGC1601 can be safely used as a potential anti-inflammatory functional probiotic agent.

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Anti-inflammatory potential of Lactiplantibacillus plantarum IDCC 3501 and its safety evaluation

Cited by 19 publications

References 31 publications

Safety Assessment of One Lactiplantibacillus plantarum Isolated from the Traditional Chinese Fermented Vegetables—Jiangshui

Safety Assessment of One Lactiplantibacillus plantarum Isolated from the Traditional Chinese Fermented Vegetables—Jiangshui

Antioxidant Activity and Probiotic Properties of Lactic Acid Bacteria

Anti-Inflammatory Effects of Limosilactobacillus fermentum KGC1601 Isolated from Panax ginseng and Its Probiotic Characteristics

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