Anti-inflammatory potential of some eudesmanolide and guaianolide sesquiterpenes

Abstract

Ten sesquiterpene lactones isolated from Anvillea garcinii (Burm.f.) DC ethanolic extract were assessed for their anti-in ammatory potential by myeloperoxidase (MPO) activity assignment, and mice paw swelling model. 3α,4α-10β-trihydroxy-8α-acetyloxyguaian-12,6α-olide (1), epi-vulgarin (3), 9ahydroxyparthenolide (4), garcinamine C (7), garcinamine D (8), garcinamine E (9), and 4, 9dihydroxyguaian-10( 14)-en-12-olide (10) showed explicit anti-in ammatory activity in rodent paw oedema and MPO assignment.The ndings of this study showed that the α-methylene γ-lactone moiety does not always guarantee an anti-in ammatory effect, but the presence of proline at the C 3 of the lactone ring improves the binding of sesquiterpene lactones with MPO isoenzymes, resulting in a more potent inhibition.