ANTI-INFLAMMATORY PREDICTION OF PERONEMIN COMPOUNDS FROM SUNGKAI (Peronema canescens Jack) AND THEIR DERIVATIVES

Abstract

Seven Sungkai Peronemins compounds belong to the alkaloid group, Peronemin A2, A3, B1, B2, B3, C1, and D1. Sungkai contains several bioactive compounds, triterpenoids, alkaloids, flavonoids, phenolics, steroids, and saponins which can act as anti-inflammatory candidates. Geometry optimization to find the most stable molecular structure and SMILES of the peronemin compound was used to predict pIC50 using the pChEMBL® program. From the test results of seven peronemin compounds, several candidate target molecules were obtained as potential anti-inflammatory agents, namely Angiotensin II type 2 (AT-2) receptors, Dihydrofolate reductase, and Phosphodiesterase 7A. Of the three target molecules, the Angiotensin II type 2 (AT-2) receptor on peronemin C1 has the highest pIC50 value of 6.79. The highest pIC50 value indicates an exponentially potent inhibitor in determining its biological activity. The anti-inflammatory function of AT-2 is revealed by its involvement in modulating mediators such as cytokines and chemokines.

Synergistic Antibacterial Effects of Combined Phytochemicals of Endophytic Fungi Extracts and Its Pure Compounds Isolated from Sungkai (Peronema canescens) Leaves

“…A typical compound from the sungkai, namely peronemin, has shown pharmacological effects as antiplasmodium, anticancer, cytotoxic, antidiabetic, antioxidant, antibacterial, antityrosinase, antiparasitic, antihyperuricemic and antiinflammatory. Based on these pharmacological effects, the sungkai leaves has great potential as an immunostimulant because several of these pharmacological effects are related to improving the immune system both directly and indirectly [9][10][11].…”

Formulation and Characterization of a Microencapsulant of Sungkai Leaves Ethanol Extract (<em>Peronema canescens</em> Jack)

“…This plant is traditionally used by the community in medicine or health care, such as bruising medicine, fever medicine, cold medicine, worming medicine, and mouthwash [2]. P. canescens contains bioactive compounds that play as antidiaberics [3], antihyperurisemia [4], anti-inflammatory [5], potential anticancer [6], and immunostimulant [7]. Other studies mention that P. canescens has potential bioactivity as an antibacterial and antioxidant.…”