Anti-inflammatory properties and phenolic profile of six Moroccan date fruit (Phoenix dactylifera L.) varieties

Bouhlali, Eimad dine Tariq; El-Hilaly, Jaouad; Ennassir, Jamal; Benlyas, Mohamed; Alem, Chakib; Amarouch, Mohamed Yassine; Filali-Zegzouti, Younes

doi:10.1016/j.jksus.2017.08.011

Cited by 44 publications

(42 citation statements)

References 35 publications

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“…Although the exact mechanism of the membrane stabilization by the LSEO extract is not known yet, hypotonicity-induced hemolysis may arise from shrinkage of the cells due to osmotic loss of intracellular electrolyte and fluid components. The LSEO may inhibit the processes, which may stimulate or enhance the efflux of these intracellular components [23]. Karthik et al [24] have reported that the lavender EO presented RBC membrane stabilization action by preventing hypotonicity-induced lysis of erythrocyte membrane.…”

Section: Chemical Composition Of Lavandula Stoechas Essential Oilmentioning

confidence: 99%

“…The most commonly used drugs for management of inflammatory conditions are NSAIDs and steroids, which have several adverse effects, especially gastric irritation leading to formation of gastric ulcers [21][22][23]. Denaturation of tissue proteins is one of the well-documented causes of inflammation.…”

Section: Inhibition Of Denaturation Of Bovine Serum Albuminmentioning

confidence: 99%

“…Therefore, protection against protein denaturation, which was the central mechanism of action of NSAIDs, could play an important part in anti-rheumatic and anti-inflammatory actions. The anti-inflammatory effect of EOs may be due to the presence of oxygenated monoterpenes such as eucalyptol and linalool either singly or in combination [23,25].…”

Section: Inhibition Of Denaturation Of Bovine Serum Albuminmentioning

confidence: 99%

“…Inflammatory illnesses are presently treated with steroidal and NSAIDs. Unfortunately, both of these widely prescribed treatment classes have important harmful side effects and fail in certain segments of the population [23]. Therefore, there is a need to develop and produce new treatments with novel mechanisms of action that do not generate significant side effects.…”

Section: Carrageenan-induced Paw Edemamentioning

confidence: 99%

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A New Eucalyptol-Rich Lavender (Lavandula stoechas L.) Essential Oil: Emerging Potential for Therapy against Inflammation and Cancer

et al. 2020

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Background/Aim: natural products are a potential source for drug discovery and development of cancer chemoprevention. Considering that drugs currently available for the treatment of inflammatory and cancer conditions show undesirable side effects, this research was designed to evaluate, for the first time, the in vitro anticancer activity of Algerian Lavandula stoechas essential oil (LSEO) against different cancer cell lines, as well as its in vitro and in vivo topical and acute anti-inflammatory properties. Materials and Methods: the LSEO was extracted by steam distillation, and chemical composition analysis was performed using gas chromatography. The main compounds identified in LSEO were oxygenated monoterpenes, such as 1,8-Cineole (61.36%). LSEO exhibited a potent anti-inflammatory activity using the xylene-induced mouse ear edema model. Results: LSEO (200 and 20 mg/kg) was able to significantly reduce (p < 0.05) the carrageenan-induced paw edema with a similar effect to that observed for the positive control. Topical application of LSEO at doses of 82 and 410 mg/kg significantly reduced acute ear edema in 51.4% and 80.1% of the mice, respectively. Histological analysis confirmed that LSEO inhibited the skin inflammatory response. Moreover, LSEO was tested for its antitumor activity against different cancer cell lines. LSEO was found to be significantly active against human gastric adenocarcinoma (AGS), Melanoma MV3, and breast carcinoma MDA-MB-231 cells, with median inhibitory concentration (IC50) values of 0.035 ± 0.018, 0.06 ± 0.022 and 0.259 ± 0.089 µL/mL, respectively. Altogether, these results open a new field of investigation into the characterization of the molecules involved in anti-proliferative processes. Conclusion: We suggest that LSEO, with 1,8-Cineole as the major active component, is a promising candidate for use in skin care products with anti-inflammatory and anticancer properties. The results of this study may provide an experimental basis for further systematic research, rational development, and clinical utilization of lavender resources.

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Section: Chemical Composition Of Lavandula Stoechas Essential Oilmentioning

confidence: 99%

Section: Inhibition Of Denaturation Of Bovine Serum Albuminmentioning

confidence: 99%

Section: Inhibition Of Denaturation Of Bovine Serum Albuminmentioning

confidence: 99%

Section: Carrageenan-induced Paw Edemamentioning

confidence: 99%

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A New Eucalyptol-Rich Lavender (Lavandula stoechas L.) Essential Oil: Emerging Potential for Therapy against Inflammation and Cancer

et al. 2020

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“…These effects are close to that reported for indomethacin (IC 50 = 86.07 μg/mL) which is the standard antiinflammation drug. This result may be due to the high quantity of polyphenols found in these Thymus species, which are found to promote anti-inflammatory activity [21]. Indeed, Ali et al [22] showed, using bovine serum albumin (BSA) and bovine ß-lactoglobulin that the gallic acid, caffeic acid, and coumaric acid improved thermal stability of these proteins.…”

Section: Anti-inflammatory Activity Inhibition Of Protein Denaturationmentioning

confidence: 99%

Antioxidant, anti-inflammatory and anticoagulant activities of three Thymus species grown in southeastern Morocco

et al. 2019

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Background: Thyme has been used for centuries in southeastern Morocco to treat a wide range of diseases such as inflammation disorders. The aim of the current study is to examine and to compare in vitro the anti-inflammatory, antioxidant, and anticoagulant activities of three thyme species grown in southeastern Morocco. Results: Data showed that all studied species possess an important antioxidant activity: Thymus atlanticus (IC 50 = 16.59 μg/mL), Thymus zygis (IC 50 = 15.43 μg/mL), and Thymus satureioides (IC 50 = 14.65 μg/mL). Concerning the antiinflammatory activity, the highest effect was depicted in Thymus atlanticus followed by Thymus zygis and Thymus satureioides. With regard to the anticoagulant activity, the aqueous extract of these species prolongs activated partial thromboplastin time, prothrombin time, and thrombin time significantly (p < 0.05) in a dose-dependent manner. Conclusion: Our results provide evidence that thymus extract exhibits marked antioxidant, anticoagulant, and antiinflammatory effects, thus justifying the popular uses of these plants to treat some inflammatory and cardiovascular illnesses.

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Assessment of Correlation Analysis, Phytochemical Profile, and Biological Activities of EndemicScorzoneraSpecies from Turkey

Sarıaltın

Açıkara

2022

Chemistry & Biodiversity

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Scorzonera species belong to the Asteraceae family comprising more than 25000 species. The present study aimed to examine the phytochemical profiles and biological activities of S. sandrasica Hartvig et Strid, S. coriacea A. Duran&Aksoy, and S. ahmet-duranii Makbul&Coskuncelebi which are endemic species to Turkey. Flavonoids such as hyperoside, isoquercitrin, rutin, isoorientin, orientin, 7-O-methyl isoorientin, luteolin-7-O-β-glycoside, apigenin-7-O-β-glucoside, vitexin, isovitexin as well as caffeoylquinic acid derivatives including chlorogenic acid, 4,5-O-dicaffeoylquinic acid, and 1,5-O-dicaffeoylquinic acid contents were analyzed to clarify phytochemical content of the extracts. Aerial parts of the investigated extracts were determined as contain flavonoids in high amounts. Chlorogenic acid and its derivatives were detected in all investigated species, in varying amounts, both in the roots and aerial parts. S. coriacea aerial parts contained the highest total phenolic and flavonoids. The strongest inhibitory activities on ABTS and DPPH radicals were also observed with S. coriacea aerial parts by 8.07 � 0.28 and 13.94 � 0.53 μg/ml of IC 50 values, respectively. Total phenolic contents of the extracts were significantly correlated with DPPH (r = À 0.9842, p = 0.0004) and ABTS free radical scavenging (r = À 0.9870, p = 0.0003) and total antioxidant capacity (r = 0.8173, p = 0.0470), as well as total flavonoid contents (r = 0.8820, p = 0.0201). S. sandrasica aerial parts and S. ahmet-duranii roots exhibited the greatest red blood cell membrane protection and protein denaturation inhibition, respectively. From the phytochemical point of view, all the selected species were analyzed for the first time.

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Anti-inflammatory properties and phenolic profile of six Moroccan date fruit (Phoenix dactylifera L.) varieties

Cited by 44 publications

References 35 publications

A New Eucalyptol-Rich Lavender (Lavandula stoechas L.) Essential Oil: Emerging Potential for Therapy against Inflammation and Cancer

A New Eucalyptol-Rich Lavender (Lavandula stoechas L.) Essential Oil: Emerging Potential for Therapy against Inflammation and Cancer

Antioxidant, anti-inflammatory and anticoagulant activities of three Thymus species grown in southeastern Morocco

Assessment of Correlation Analysis, Phytochemical Profile, and Biological Activities of EndemicScorzoneraSpecies from Turkey

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