Anti-inflammatory properties of copper implants in the rat paw edema: A preliminary study

Abstract

Metallic copper has been shown to possess anti-inflammatory activity in the carrageenan foot paw edema of the rat, when applied in the form of an implant. The implant was installed two months before the edema was induced. It is postulated that the anti-inflammatory activity is due to dissolved copper from the implant.

Review: Copper and inflammation — a possible rationale for the pharmalogical manipulation of inflammatory discorders

“…From the above studies a few points emerge that need to be stressed: (1) copper is active per se as an acute antiinflammatory agent regardless of the chemical form in which it is administered, even in such forms as inorganic copper salts [43], copper salts or complexes with simple organic molecules possessing or not antiinflammatory properties on their own [44][45][46], copper atoms carried by proteins such as superoxidc dismutase derivatives [47,48], ceruloplasmin [49] and other oxidases [50], and, finally, metallic copper directly implanted in the body [51]. (2) Unless special vehicles are used [8], the routes of administration normally effective in the rat are all those which exclude the absorption through the gastrointestinal tract.…”

Post-surgical wireless monitoring of arterial health progression

“…Copper has historically used in implanted devices for over 50 years (Zipper et al, 1969). In fact, copper has demonstrated anti-inflammatory properties in implants (Dollwet et al, 1981). However, it is important to note that the copper layer is fully encapsulated by the PDMS and, thus, is not expected to come in contact with the body.…”