Anti-Inflammatory Properties of Drugs from saffron crocus

Poma, Anna; Fontecchio, G; Carlucci, Giuseppe; Chichiriccò, Giuseppe

doi:10.2174/187152312803476282

Cited by 108 publications

(66 citation statements)

References 74 publications

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“…Stigmas were harvested from mature flowers (C. sativus L; Iridaceae) [119]. Pharmacological studies on saffron demonstrated numerous health properties such as anticancer and antitoxic [120], antioxidant [121], antinociceptive and anti-inflammatory [122], antiatherosclerosis [123], antidiabetic and insulin resistance [124], hypotensive [125], hypolipidemic [126], hypoglycemic [127], and antidepressant and mood improving [128]. It is a source of plant polyphenols and carotenoids.…”

Section: Saffronmentioning

confidence: 99%

Obesity and Clinical Riskiness Relationship: Therapeutic Management by Dietary Antioxidant Supplementation—a Review

Hassan

El-Gharib

2015

Appl Biochem Biotechnol

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Obesity is a global health problem affecting all age groups, leading to many complications such as type 2 diabetes, systemic hypertension, cardiovascular disease, dyslipidemia, atherosclerosis, and stroke. Physiologically, obesity arises from metabolic changes in the tissues and organs of the human body; these changes result in an imbalance between energy intake and energy expenditure, which in turn results in increased fat accumulation in adipose tissue. Such fat accumulation predisposes individuals to development of several health problems. Two different obesity treatment drugs are currently on the market; Orlistat, which reduces intestinal fat absorption via inhibiting pancreatic lipase, and Sibutramine, an anorectic or appetite suppressant. Both drugs have hazardous side effects, including increased blood pressure, dry mouth, constipation, headache, and insomnia. For this reason, a wide variety of natural materials have been explored for their obesity treatment potential. Therefore, the present review focuses on the safety and efficacy of some herbal medicines in the management of obesity through covering their beneficial effects and mechanism of action.

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Section: Saffronmentioning

confidence: 99%

Obesity and Clinical Riskiness Relationship: Therapeutic Management by Dietary Antioxidant Supplementation—a Review

Hassan

El-Gharib

2015

Appl Biochem Biotechnol

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“…Bitter substances derived from safranal and crocin carotenoid pigment (an important component of saffron stigma) are said to have pharmacological effects (7,8). Some studies investigated the many medicinal applications of saffron including induction of abortion (9), increasing uterine contractions (10,11), analgesic and antiinflammatory properties (12)(13)(14), anti-anxiety (15)(16)(17), sedation (18), and labor pain (19). Authors' recent trial also showed that oral capsules of saffron increased the Bishop score in term pregnant females with no labor pain (20).…”

Section: Introductionmentioning

confidence: 99%

Effect of Saffron with or Without Date Sugar on Intensity of Pain and Anxiety During Labor in Primiparous Females: A Randomized, Controlled Trial

Mohammadierad¹,

Mohammad‐Alizadeh‐Charandabi²,

Mirghafourvand³

et al. 2018

Iran Red Crescent Med J

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Background: Reduction of pain and anxiety during labor is necessary to prevent some of the maternal and fetal complications, as well as request for cesarean section. There is limited evidence assessing the effects of saffron and dates on intensity of pain and anxiety. Objectives: The current study aimed at examining the effect of saffron with or without dates on the intensity of pain and anxiety during transitional and active phases of labor in primiparous females. Methods: In the current superiority trial, 96 primiparous females admitted to a hospital covered by the iranian social security organization in Tabriz, Iran, at the onset of active phase of labor were recruited using convenience sampling method from 10 January to 21 October 2016. They were randomly divided into three equal groups using block randomization; receiving 80 mL oral syrup of saffron (250 mg) plus date juice (65 g), saffron (250 mg) plus white sugar (165 mg sodium saccharin and 420 mg sodium carboxymethyl cellulose), or placebo every two hours for maximum three doses (240 mL). Intensity of pain and anxiety were assessed using 0-10 visual analogue scale every one hour. Results: Compared with the placebo, mean scores of both pain and anxiety were lower in the intervention groups. The differences were statistically significant at the saffron plus date juice group (adjusted mean difference: -0.8 (95% confidence interval (CI): -1.5 -0.0), P = 0.022 and -1.3 (95% CI: -2.4 to -0.2), P = 0.012, respectively), but were not significant at the saffron plus white sugar group (-0.5 (95% CI: -1.2 -0.2), P = 0.322 and -1.1 (95% CI: -2.2 -0.0), P = 0.058, respectively). The differences between the two intervention groups were not statistically significant (-0.3 (95% CI: -1.0 -0.4), P = 0.557 and -0.2 (95% CI: -1.3 -0.8), P = 0.927, respectively). One subject from saffron plus date juice, three from saffron plus white sugar, and four from the placebo groups had emergency cesarean section. Conclusions: The current study results showed that the oral syrup of saffron plus date juice could be used to reduce the intensity of pain and anxiety during labor in primiparous females. However, the results were inconclusive for the effects of saffron plus white sugar.

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“…A natural carotenoid of saffron, crocin, is responsible for its beneficial effects including anti-oxidant (Tseng et al 1995), anti-inflammatory (Poma et al 2012), and anti-tumoral properties, demonstrated in some cancer cell lines and animal models (Abdullaev 1994;Dhar et al 2009;Magesh et al 2006). Bathaie and colleagues (Bathaie et al 2013) demonstrated that this ancient herbal medicine can be used against gastric adenocarcinoma in both human and the rat model (Bathaie et al 2013).…”

Section: Saffronmentioning

confidence: 99%

Herbal remedies against gastric cancer in experimental rats

Tabrizi

Mohammadi

2016

Comp Clin Pathol

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Gastric cancer is the fourth most prevalent cancer worldwide, which claims more than 700,000 lives every year. However, the current chemical and surgical management of this mortal cancer remains far from successful. A recent safe approach to preventing or treating tumorigenesis has been the re-introduction of traditional herbal medicine, taking advantage of efficient, yet natural healthy products. In this review, we have focused on a number of such popular agents, mostly introduced by the Traditional Chinese medicine (TCM), which have exhibited highly significant preventive/ therapeutic effects against various gastric pathologies, ranging from gastritis to premalignant lesions and confirmed malignancies, in experimental rats. The underlying mechanisms of action seem to concentrate on shifting the balance between in vivo oxidant and anti-oxidant activities. In addition, the existing reports on the potential toxicity of these compounds, as well as their interactions with chemical drugs, have been presented. However, far more details are required to recommend herbal medicine as an effective and reliable plan of action in gastric cancer management.

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Anti-Inflammatory Properties of Drugs from saffron crocus

Cited by 108 publications

References 74 publications

Obesity and Clinical Riskiness Relationship: Therapeutic Management by Dietary Antioxidant Supplementation—a Review

Obesity and Clinical Riskiness Relationship: Therapeutic Management by Dietary Antioxidant Supplementation—a Review

Effect of Saffron with or Without Date Sugar on Intensity of Pain and Anxiety During Labor in Primiparous Females: A Randomized, Controlled Trial

Herbal remedies against gastric cancer in experimental rats

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