Anti-inflammatory properties of griseofulvin

Abstract

Anti-inflammatory activity of griseofulvin has been investigated in comparison with indomethacin and flufenamic acid. In vitro, griseofulvin has been proved the most effective of these agents in suppressing the contractions of smooth muscle preparations induced by a variety of proposed mediators of inflammation, i.e. histamine, 5-hydroxy-tryptamine, bradykinin and prostaglandin E2. In vivo, griseofulvin was unable to modify dextran oedema but suppressed carrageenin oedema, although its activity was poor when compared to that exhibited by indomethacin and flufenamic acid. When tested in rat pleurisy induced by dextran or homologous serum griseofulvin was able to prevent polymorph migration into the pleural space while mononuclears remained virtually unaffected. In contrast indomethacin and flufenamic acid mainly suppressed mononuclear migration while polymorphs resulted only slightly affected. Similar results have been exhibited by the drugs when tested on mononuclear turnover in pleural cavities from normal rats. Results are discussed in the light of the clinically established ability of griseofulvin to prevent cutaneous inflammatory reactions as well as of its effectiveness in the treatment of several polyarthritic syndromes.

Electrospray ionization LC–MS/MS validated method to quantify griseofulvin in human plasma and its application to bioequivalence study

“…It gets deposited in keratin precursor cells, which become resistant to the invasion of dermatophytes. Other than its fungistatic effect, griseofulvin has demonstrated non-cortisone anti-inflammatory properties and some direct vasodilatory effect when used in high doses [3]. It is mainly absorbed in the duodenum and to a lesser extent in the jejunum and ileum after oral ingestion.…”

Inhibited proliferation of human scleroderma skin fibroblasts and rheumatoid synovial cells with griseofulvin in vitro

“…These are characteristic actions of anti-inflammatory drugs. in agreement wilh previous reports of anti-inflamma tory activity for griseofulvin (9) Prolifcration tests were performed as described pre viously (7), using rcplicare cultures in small flasks (25 cm' a r ea) seeded with I 0 5 cells. Griseofulvin was dis solved in dimethyl sulphoxide and ad ded to media to give final concentrations of 2.…”

Drug Discovery of Griseofulvin : A Review

“…b. Oral dose of griseofulvin (125-250-500 mg/kg) in rats did not inhibit dextran-induced leg edema 15 .…”