2018
DOI: 10.1016/j.jneuroim.2018.07.013
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Anti-inflammatory properties of Honokiol in activated primary microglia and astrocytes

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Cited by 40 publications
(30 citation statements)
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“…15,22 Additionally, mechanistic investigation revealed that honokiol influenced the activation of microglial cells by modulating the production of nitric oxide (NO), pro-inflammatory and anti-inflammatory cytokines. 23 These results suggest that honokiol is a promising phytochemical to be developed as a potential anti-inflammatory and neuroprotective agent against inflammatory CNS diseases. However, the clinical application of honokiol is hampered by its low aqueous solubility and poor feasibility for intravenous administration.…”
Section: Introductionmentioning
confidence: 94%
“…15,22 Additionally, mechanistic investigation revealed that honokiol influenced the activation of microglial cells by modulating the production of nitric oxide (NO), pro-inflammatory and anti-inflammatory cytokines. 23 These results suggest that honokiol is a promising phytochemical to be developed as a potential anti-inflammatory and neuroprotective agent against inflammatory CNS diseases. However, the clinical application of honokiol is hampered by its low aqueous solubility and poor feasibility for intravenous administration.…”
Section: Introductionmentioning
confidence: 94%
“…Two are known for their propensity to induce macropinocytosis—i.e., vacquinol-1 [27] and MOMIPP [29]—while the last one, honokiol, is a natural bioactive polyphenol extracted from several parts of Magnolia genus tree [30] (Figure 4). The latter displays various well-known pharmacological properties, such as anti-oxidant [31], neuro-protective [32] and anti-inflammatory effects in both microglia and astrocytes [33]. These properties explain the traditional use of honokiol for the treatment of thrombotic stroke, gastrointestinal complaints, anxiety and nervous disturbance [34].…”
Section: Resultsmentioning
confidence: 99%
“…We recently proposed to explore the scaffold of 4 -O-methylhonokiol (MH in Scheme 1A), a natural biphenolic compound known for strong anti-inflammatory and neuroprotective activities [15][16][17], to design potential COX-2 radioligands. Radioligand [ 11 C]MPbP (4 -[ 11 C]methoxy-5-propyl-1,1 -biphenyl-2-ol) showed a high brain uptake in LPS (lipopolysaccharide)-treated rats compared to control animals [18].…”
Section: Introductionmentioning
confidence: 99%