Anti‐inflammatory properties of intestinal <i>Bifidobacterium</i> strains isolated from healthy infants

Хохлова, Е. В.; Smeianov, Vladimir V.; Ефимов, Б. А.; Кафарская, Л. И.; Павлова, С. И.; Shkoporov, Andrey N.

doi:10.1111/j.1348-0421.2011.00398.x

Cited by 89 publications

(60 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…and the reduction in Campylobacterales observed in AD mice upon administration with SLAB51 is important for the role of these bacteria in inflammatory pathways. In fact, Bifidobacterium strains possess anti-inflammatory properties principally attributed to small heat-stable, non-lipophilic compounds resistant to protease and nuclease treatments 71 . Moreover, certain species of genus Bifidobacterium could negatively modulate mRNA levels of pro-inflammatory cytokines produced from LPS-stimulated macrophages 72 .…”

Section: Discussionmentioning

confidence: 99%

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

Bonfili

Cecarini

Berardi

et al. 2017

Sci Rep

364

283

View full text Add to dashboard Cite

Gut microbiota has a proven role in regulating multiple neuro-chemical pathways through the highly interconnected gut-brain axis. Oral bacteriotherapy thus has potential in the treatment of central nervous system-related pathologies, such as Alzheimer’s disease (AD). Current AD treatments aim to prevent onset, delay progression and ameliorate symptoms. In this work, 3xTg-AD mice in the early stage of AD were treated with SLAB51 probiotic formulation, thereby affecting the composition of gut microbiota and its metabolites. This influenced plasma concentration of inflammatory cytokines and key metabolic hormones considered therapeutic targets in neurodegeneration. Treated mice showed partial restoration of two impaired neuronal proteolytic pathways (the ubiquitin proteasome system and autophagy). Their cognitive decline was decreased compared with controls, due to a reduction in brain damage and reduced accumulation of amyloid beta aggregates. Collectively, our results clearly prove that modulation of the microbiota induces positive effects on neuronal pathways that are able to slow down the progression of Alzheimer’s disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

Bonfili

Cecarini

Berardi

et al. 2017

Sci Rep

364

283

View full text Add to dashboard Cite

show abstract

“…On the other hand, the mechanisms involved in the immunoregulatory activities of bifidobacteria have been less studied. Recent work has begun to elucidate the mechanisms as well as the effector molecules involved in the immunomodulatory effect of bifidobacteria [15,16,17]. It is believed that the beneficial effects of bifidobacteria require biological interactions with the intestinal epithelium.…”

Section: Discussionmentioning

confidence: 99%

<i>Bifidobacterium breve</i> MCC-117 Induces Tolerance in Porcine Intestinal Epithelial Cells: Study of the Mechanisms Involved in the Immunoregulatory Effect

Murata

Tomosada

Villena

et al. 2014

Bioscience of Microbiota, Food and Health

View full text Add to dashboard Cite

Bifidobacterium breve MCC-117 is able to significantly reduce the expression of inflammatory cytokines in porcine intestinal epithelial (PIE) cells and to improve IL-10 levels in CD4+CD25high Foxp3+ lymphocytes in response to heat-stable enterotoxigenic Escherichia coli (ETEC) pathogen-associated molecular patterns (PAMPs), while the immunoregulatory effect of B. adolescentis ATCC15705 was significantly lower than that observed for the MCC-117 strain. Considering the different capacities of the two bifidobacterium strains to activate toll-like receptor (TLR)-2 and their differential immunoregulatory activities in PIE and immune cells, we hypothesized that comparative studies with both strains could provide important information regarding the molecular mechanism(s) involved in the anti-inflammatory activity of bifidobacteria. In this work, we demonstrated that the anti-inflammatory effect of B. breve MCC-117 was achieved by a complex interaction of multiple negative regulators of TLRs as well as inhibition of multiple signaling pathways. We showed that B. breve MCC-117 reduced heat-stable ETEC PAMP-induced NF-κB, p38 MAPK and PI3 K activation and expression of pro-inflammatory cytokines in PIE cells. In addition, we demonstrated that B. breve MCC-117 may activate TLR2 synergistically and cooperatively with one or more other pattern recognition receptors (PRRs), and that interactions may result in a coordinated sum of signals that induce the upregulation of A20, Bcl-3, Tollip and SIGIRR. Upregulation of these negative regulators could have an important physiological impact on maintaining or reestablishing homeostatic TLR signals in PIE cells. Therefore, in the present study, we gained insight into the molecular mechanisms involved in the immunoregulatory effect of B. breve MCC-117.

show abstract

“…(Jenq et al 2012;Shimazu et al 2012;van Baarlen et al 2013) and Bifidobacterium spp. (Imaoka et al 2008;Khokhlova et al 2012).…”

Section: T H E E F F E C T S O F G U T B a C T E R I A A N D H E L M mentioning

confidence: 99%

The microbiota and helminths: sharing the same niche in the human host

et al. 2014

View full text Add to dashboard Cite

Human gastrointestinal bacteria often share their environment with parasitic worms, allowing physical and physiological interaction between the two groups. Such associations have the potential to affect host health as well as the bacterial and helminth populations. Although still in its early stages, research on the interaction between the microbiome and parasitic helminths in humans offers the potential to improve health by manipulating the microbiome. Previously, supplementation with various nutritional compounds has been found to increase the abundance of potentially beneficial gut commensal bacteria. Thus, nutritional microbiome manipulation to produce an environment which may decrease malnutrition associated with helminth infection and/or aid host recovery from disease is conceivable. This review discusses the influence of the gut microbiota and helminths on host nutrition and immunity and the subsequent effects on the human host's overall health. It also discusses changes occurring in the microbiota upon helminth infections and the underlying mechanisms leading to these changes. There are still significant knowledge gaps which need to be filled before meaningful progress can be made in translating knowledge from studying the human gut microbiome into therapeutic strategies. Ultimately this review aims to discuss our current knowledge as well as highlight areas requiring further investigation.

show abstract

Anti‐inflammatory properties of intestinal Bifidobacterium strains isolated from healthy infants

Abstract: CIP mRNAs. Our data suggest certain species-specificities of the anti-inflammatory properties of bifidobacteria. This observation should prompt additional validation studies using larger set of strains and employing the tools of comparative genomics.

Cited by 89 publications

References 50 publications

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

<i>Bifidobacterium breve</i> MCC-117 Induces Tolerance in Porcine Intestinal Epithelial Cells: Study of the Mechanisms Involved in the Immunoregulatory Effect

The microbiota and helminths: sharing the same niche in the human host

Contact Info

Product

Resources

About