Anti-inflammatory properties of novel galloyl glucosides isolated from the Australian tropical plant Uromyrtus metrosideros

Ritmejerytė, Edita; Ryan, Rachael Y. M.; Byatt, Brendan J; Peck, Yoshimi; Yeshi, Karma; Daly, Norelle L.; Zhao, Guangzu; Crayn, Darren M.; Loukas, Alex; Pyne, Stephen G.; Ruscher, Roland; Wangchuk, Phurpa

doi:10.1016/j.cbi.2022.110124

Cited by 6 publications

(12 citation statements)

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“…Furthermore, monoterpenes, sesquiterpenes, and diterpenes were higher in young leaves than their mature leaves [ 3 , 4 ]. Recent studies conducted by Wangchuk’s group at James Cook identified the pharmaceutical potential of Australian Wet Tropics plants affected by climate change, and they have also discovered two novel drug lead molecules from one of the ecologically-directed tropical montane cloud forest plants [ 53 , 54 ]. Similarly, potent small molecules anti-inflammatory excretory-secretory products (ESP) derived from parasitic helminths were identified using metabolomics and lipidomics platforms [ 55 , 56 ].…”

Section: Approaches and Techniques For The Biodiscovery Of Anti-infla...mentioning

confidence: 99%

Approaches, Strategies and Procedures for Identifying Anti-Inflammatory Drug Lead Molecules from Natural Products

Jamtsho,

Yeshi,

Perry

et al. 2024

Pharmaceuticals

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Natural products (NPs) have played a vital role in human survival for millennia, particularly for their medicinal properties. Many traditional medicine practices continue to utilise crude plants and animal products for treating various diseases, including inflammation. In contrast, contemporary medicine focuses more on isolating drug-lead compounds from NPs to develop new and better treatment drugs for treating inflammatory disorders such as inflammatory bowel diseases. There is an ongoing search for new drug leads as there is still no cure for many inflammatory conditions. Various approaches and technologies are used in drug discoveries from NPs. This review comprehensively focuses on anti-inflammatory small molecules and describes the key strategies in identifying, extracting, fractionating and isolating small-molecule drug leads. This review also discusses the (i) most used approaches and recently available techniques, including artificial intelligence (AI), (ii) machine learning, and computational approaches in drug discovery; (iii) provides various animal models and cell lines used in in-vitro and in-vivo assessment of the anti-inflammatory potential of NPs.

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Section: Approaches and Techniques For The Biodiscovery Of Anti-infla...mentioning

confidence: 99%

Approaches, Strategies and Procedures for Identifying Anti-Inflammatory Drug Lead Molecules from Natural Products

Jamtsho,

Yeshi,

Perry

et al. 2024

Pharmaceuticals

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“…45 metabolites; major metabolitesare α-pinene, β-pinene, sabinene, α-terpinene, γ-terpinene, terpinen-4-ol and α-terpineol [128] NA Reduce skeletal muscle atrophy (sabinene) [129], antibacterial and antibiofilm activities (terpinene-4-ol) [130] Uromyrtus metrosideros NU 27 metabolites; major metabolites are α-pinene, β-pinene, spathulenol and aromadendrene [131] norbergenin, bergenin, (6S,9R)-roseoside, (4S)-α-terpineol 8-O-β-D-(6-O-galloyl) glucopyranoside, galloyl-lawsoniaside A, and uromyrtoside [132] Benzopyran, Glucoside, Anti-inflammatory (galloyl-lawsoniaside A) [132]; reduced hypertension and allergic reaction (roseoside) [133,134] Prumnopitys ladei Fruits and bark of Prunmnopitys species are considered medicinal [68]. 44-metabolites; major compounds are α-pinene, limonene, verbenone, and p-cymene.…”

Section: Leptospermum Wooroonooranmentioning

confidence: 99%

“…A total of 19 compounds/secondary metabolites were isolated from these 3 plant species (Table 2), and these compounds belong to 4 different chemical groups (alkaloids, flavonoids, benzopyrans, and glucosides). For example, two new galloyl glucosides (galloyl-lawsoniaside A and uromyrtoside) and four known compounds were isolated from Uromyrtus metrosideros [132]. These six compounds were characterised using low-and high-resolution mass spectrometry (L/HRMS) and Nuclear Magnetic Resonance (NMR) spectroscopy.…”

Section: Phytochemicals Isolated From Climate-affected Plants In Wtwhamentioning

confidence: 99%

“…Studies have suggested that SMs, which function as plant defence mechanisms, possess intriguing pharmacological properties, including antioxidant and anti-inflammatory properties [178]. For instance, a novel galloyl-lawsoniaside A isolated from U. metrosideros leaf significantly suppressed pro-inflammatory cytokines, such as interferon-gamma and interleukins-17 (IL-17) and IL-18, and thus was identified as a new anti-inflammatory druglead molecule [132]. Osthol isolated from Leionema ellipticum also showed anti-inflammatory activity [143,146].…”

Section: Pharmacological Activities Of Isolated Phytochemicals Of Cli...mentioning

confidence: 99%

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Climate-Affected Australian Tropical Montane Cloud Forest Plants: Metabolomic Profiles, Isolated Phytochemicals, and Bioactivities

Gempo,

Yeshi,

Crayn

et al. 2024

Plants

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The Australian Wet Tropics World Heritage Area (WTWHA) in northeast Queensland is home to approximately 18 percent of the nation’s total vascular plant species. Over the past century, human activity and industrial development have caused global climate changes, posing a severe and irreversible danger to the entire land-based ecosystem, and the WTWHA is no exception. The current average annual temperature of WTWHA in northeast Queensland is 24 °C. However, in the coming years (by 2030), the average annual temperature increase is estimated to be between 0.5 and 1.4 °C compared to the climate observed between 1986 and 2005. Looking further ahead to 2070, the anticipated temperature rise is projected to be between 1.0 and 3.2 °C, with the exact range depending on future emissions. We identified 84 plant species, endemic to tropical montane cloud forests (TMCF) within the WTWHA, which are already experiencing climate change threats. Some of these plants are used in herbal medicines. This study comprehensively reviewed the metabolomics studies conducted on these 84 plant species until now toward understanding their physiological and metabolomics responses to global climate change. This review also discusses the following: (i) recent developments in plant metabolomics studies that can be applied to study and better understand the interactions of wet tropics plants with climatic stress, (ii) medicinal plants and isolated phytochemicals with structural diversity, and (iii) reported biological activities of crude extracts and isolated compounds.

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“…For these reasons, many other substances have been considered to help treat IBD. Several phytochemicals, such as flavonoids, alkaloids, saponins, phenolic acids, and terpenoids, can be effective adjuvants for the therapeutic approach [ 9 , 10 , 11 ]. Figure 1 shows the main pathways involved in the pathophysiology of IBD and how the activation of the NF-kB pathways interferes with the occurrence of these diseases.…”

Section: Introductionmentioning

confidence: 99%

Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and In Vivo Effects

et al. 2023

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Inflammatory bowel diseases (IBD) are chronic relapsing idiopathic inflammatory conditions affecting the gastrointestinal tract. They are mainly represented by two forms, ulcerative colitis (UC) and Crohn’s disease (CD). IBD can be associated with the activation of nuclear factors, such as nuclear factor-kB (NF-kB), leading to increased transcription of pro-inflammatory mediators that result in diarrhea, abdominal pain, bleeding, and many extra-intestinal manifestations. Phytochemicals can interfere with many inflammation targets, including NF-κB pathways. Thus, this review aimed to investigate the effects of different phytochemicals in the NF-KB pathways in vitro and in vivo models of IBD. Fifty-six phytochemicals were included in this study, such as curcumin, resveratrol, kaempferol, sesamol, pinocembrin, astragalin, oxyberberine, berberine hydrochloride, botulin, taxifolin, naringin, thymol, isobavachalcone, lancemaside A, aesculin, tetrandrine, Ginsenoside Rk3, mangiferin, diosgenin, theanine, tryptanthrin, lycopene, gyngerol, alantolactone, mangostin, ophiopogonin D, fisetin, sinomenine, piperine, oxymatrine, euphol, artesunate, galangin, and nobiletin. The main observed effects related to NF-kB pathways were reductions in tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6, interferon-gamma (IFN-γ), and cyclooxygenase-2 (COX-2), and augmented occludin, claudin-1, zonula occludens-1, and IL-10 expression levels. Moreover, phytochemicals can improve weight loss, stool consistency, and rectal bleeding in IBD. Therefore, phytochemicals can constitute a powerful treatment option for IBD in humans.

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Anti-inflammatory properties of novel galloyl glucosides isolated from the Australian tropical plant Uromyrtus metrosideros

Cited by 6 publications

References 60 publications

Approaches, Strategies and Procedures for Identifying Anti-Inflammatory Drug Lead Molecules from Natural Products

Approaches, Strategies and Procedures for Identifying Anti-Inflammatory Drug Lead Molecules from Natural Products

Climate-Affected Australian Tropical Montane Cloud Forest Plants: Metabolomic Profiles, Isolated Phytochemicals, and Bioactivities

Phytochemicals and Regulation of NF-kB in Inflammatory Bowel Diseases: An Overview of In Vitro and In Vivo Effects

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