Anti-Inflammatory Sesquiterpenoid Dimers from Artemisia Atrovirens

Artemongolides A–F, undescribed sesquiterpenoid dimers from Artemisia mongolica and their antihepatic fibrosis activities

“…Sesquiterpenoid dimers (SDs) are biologically formed by two molecules of sesquiterpenoid through Diels-Alder, [2 + 2] cycloaddition and ester linkage adducts 1 and have attracted a lot of attention owing to their significant antitumor, [2][3][4][5][6] antiinflammatory, 7 antiviral, 8 and antihepatic fibrosis activities. 9,10 SDs are a characteristic group of components in Artemisia species.…”

“…9,10 SDs are a characteristic group of components in Artemisia species. To date, 172 natural SDs have been reported from the genus Artemisia, 2,7,[11][12][13][14][15][16][17][18] of which only 13 seco-guaianolide dimers were found. 7,[16][17][18] However, farnesane-guaiane type dimers had never been obtained.…”

“…Prod. Rep., 2020, 37(7), 999-1030.Organic & Biomolecular Chemistry PaperThis journal is © The Royal Society of Chemistry 2023Org. Biomol.…”