Anti-inflammatory strategies in the treatment of schizophrenia

Andrade, Chittaranjan

doi:10.1586/17512433.2016.1095086

Cited by 21 publications

(11 citation statements)

References 19 publications

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“…Hence astrocyte transcriptome changes that are shifted by pathogen-associated molecular patterns (PAMPSs) including LPS and associated cytokines (Sofroniew, 2015). Astrocytes also regulate the function of microglia during injury or recovery of the brain via secreted cytokines (Miyake et al, 2011;Bouzier-Sore and Pellerin,2013;Bernstein et al, 2015;Andrade 2016;Dean et al, 2016).…”

Section: Inflammatory Processes and Astrocytesmentioning

confidence: 99%

Alterations of Astrocytes in the Context of Schizophrenic Dementia

et al. 2020

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The levels of the astrocyte markers (GFAP, S100B) were increased unevenly in patients with schizophrenia. Reactive astrogliosis was found in approximately 70% of patients with schizophrenia. The astrocytes play a major role in etiology and pathogenesis of schizophrenia. Astrocytes produce the components that altered in schizophrenia extracellular matrix system which are involved in inflammation, functioning of interneurons, glio-, and neurotransmitter system, especially glutamate system. Astrocytes activate the interneurons through glutamate release and ATP. Decreased expression of astrocyte glutamate transporters was observed in patients with schizophrenia. Astrocytes influence on N-methyl-d-aspartate (NMDA) receptors via Dserine, an agonist of the glycine-binding site of NMDA receptors, and kynurenic acid, an endogenous antagonist. NMDA receptors, on its turn, control the impulses of dopamine neurons. Therefore following theories of schizophrenia are proposed. They are a) activation of astrocytes for neuroinflammation, b) glutamate and dopamine theory, as astrocyte products control the activity of NMDA receptors, which influence on the dopamine neurons.

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Section: Inflammatory Processes and Astrocytesmentioning

confidence: 99%

Alterations of Astrocytes in the Context of Schizophrenic Dementia

et al. 2020

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“…Citicoline enhances the norepinephrine and dopamine levels and attenuates brain glutamate activity in specific regions of the brain (Fioravanti & Buckley, ). These functions, as well as its anti‐inflammatory effects, are part of the hypothetical mechanisms of action of citicoline in negative symptoms of schizophrenia (Andrade, ).…”

Section: Discussionmentioning

confidence: 99%

Citicoline (CDP‐choline) add‐on therapy to risperidone for treatment of negative symptoms in patients with stable schizophrenia: A double‐blind, randomized placebo‐controlled trial

Ghajar

Gholamian

Tabatabei-Motlagh

et al. 2018

Human Psychopharmacology

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“…Interleukin 6 (IL-6) was found to increase with aging and higher levels of this cytokine have been associated with an increased risk of both cardiovascular events and non-cardiovascular death (Akbaraly et al 2013). The inflammatory hypothesis of schizophrenia has recently regained interest also in light of the several data describing the efficacy of some components, such as aspirin or celecoxib, on symptom severity (Sommer et al 2014, Andrade 2016. Similarly TNF-alpha inhibitors have been proposed for the treatment of depression (Schmidt et al 2014, Kaster et al 2016).…”

Section: Aging Versus Neurodegenerationmentioning

confidence: 99%