Anti-inflammatory Terpenoids from the Leaves and Twigs of Dysoxylum gotadhora

Abstract

Nine new terpenoids (1-3, 5-10), including three cyclolanostane triterpenoids (1-3) and six isopimarane diterpenoids (5-10), along with six known terpenoids (4, 11-15), were isolated from the leaves and twigs of Dysoxylum gotadhora. Compound 1 represents a class of rare natural 21,24-epoxy cyclolanostane-type triterpenoids, and compounds 2 and 3 are the first examples of 21,25-epoxy cyclolanostane-type triterpenoids. Compounds 1, 2, 4, 8, and 15 exhibited noteworthy inhibition of nitric oxide production induced by lipopolysaccharide in RAW 264.7 cells with IC50 values of 25.5, 41.5, 27.4, 14.5, and 45.2 μM, respectively.

Antiproliferative and anti-inflammatory polyhydroxylated spirostanol saponins from Tupistra chinensis

“…The crude extracts of T. chinensis TB, TC and TD showed moderate inhibition on NO production with IC 50 values of 32.6 ± 3.7, 37.5 ± 5.4 and 36.6 ± 1.8 μg/mL (see Table S3 in the supporting information ). Compound 21 showed significant inhibition on NO production with IC 50 values of 11.5 μM, comparable to that of the positive control indomethacin.at 47.4 μM 38 . Compounds 1 , 4 , 9 , 10 , 13 , 14 , 17 and 20 exhibited moderate inhibition with IC 50 values between 21.7 and 33.6 μM.…”

Natural Products Research in China From 2015 to 2016

“…Compound 342 represented a naturally occurring 21,24-epoxy cyclolanostane-type triterpenoids, while compounds 343 and 344 were the first examples of 21,25-epoxy cyclolanostanetype triterpenoids. Triterpenoid 342 as well as isopimarane diterpenoids 345 and 346 were active against NO production induced by LPS in RAW 264.7 cells with IC 50 values of 25.5, 27.4, and 14.5 μM (indomethacin, 21.5 μM) (Jiang et al, 2015a ). Isolation of the root bark of Aphanamixis grandifolia (Yunnan, China) afforded 14 new diterpene dimers, aphanamenes C–P.…”

Terpenoids as Source of Anti-Inflammatory Compounds

“…Significantly inhibited the expression of TNF-α in murine neutrophils and also reduced the IL (IL-6 and IL-8) and NO production levels [13]. Anti-inflammatory effect of Ocimum labiatum ethanolic extract and an isolated diterpenoid was determined using a cytometric bead array technique.…”