Anti‐inflammatory therapy in cystic fibrosis

Azithromycin reduces spontaneous and induced inflammation in ΔF508 cystic fibrosis mice

“…Active treatment of lung disease is a cornerstone of CF management. This may include anti-inflammatory therapy approaches in combination with other conventional therapies such as antibiotics [ 11 , 12 ]. Azithromycin, a macrolide antibiotic structurally modified from erythromycin, has been used to treat CF patients resulting in significant clinical improvement in lung function with a reduction in pulmonary exacerbations and fewer courses of antibiotic use [ 13 - 16 ].…”

Benefits of breastfeeding in cystic fibrosis: A single‐centre follow‐up survey

“…In view of the importance of proper nutrition in infants with CF, it may be adequate to feed them exclusively with breast milk for at least 6 months as recommended for all infants by WHO (7), so that infants with CF not only will be provided with optimal requirements of macro‐ and micronutrients, but could also benefit from the modulating properties of human milk on the immune system (8). Indeed, infants with CF could more effectively take advantage from the functional effects of breastfeeding (BF), because the disease is characterised by an excess of the inflammatory response to exogenous and endogenous factors (9). In accordance, American and European nutritional guidelines have recently recommended BF for the first year of life in patients with CF (10,11).…”

Inflammation, Hyperinflammation & Cystic Fibrosis Lung Disease – A Paradigm Shift?

“…Several reviews introducing traditional pharmacological approaches to the amelioration of the inflammatory response in the CF lung have been published to date [50,128]. Instead here we consider specific targets secondary to our understanding, however imperfect, of the hyperinflammatory phenotype.…”