Anti-inflammatory tirucallane triterpenoids from Anopyxis klaineana Pierre (Engl.), (Rhizophoraceae)

Mireku, Evelyn Afua; Kusari, Souvik; Eckelmann, Dennis; Mensah, Abraham Yeboah; Talontsi, Ferdinand Mouafo; Spiteller, Michael

doi:10.1016/j.fitote.2015.08.007

Cited by 21 publications

(12 citation statements)

References 26 publications

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“…In another study, a tirucallane triterpenoid isolated from the stem bark namely 3,23-dioxotirucalla-7,24-dien-21-oic acid, exhibited remarkable anti-inflammatory activity in a PGE 2 competitive inhibition immunoassay with an IC 50 value of 3.63 μM which was comparable to the positive control, cortisone (IC 50 = 2.59 μM). Methyl angolensate further demonstrated remarkable competitive inhibition of PGE 2 with an IC 50 of 10.23 μM confirming its in-vivo anti-inflammatory effect [30]. C. procera is a medium-large sized bushy shrub which grows on coarse, sandy or alkaline soils of West and East Africa also found in the Indian Ocean islands and the north of South Africa.…”

Section: Anopyxis Klaineana (Pierre) Engl (Rhizophoraceae)mentioning

confidence: 73%

Analgesic and Anti-Inflammatory Effect of Ghanaian Medicinal Plants

Asante-Kwatia¹,

Mensah²,

Baidoo³

2020

Medicinal Plants - Use in Prevention and Treatment of Diseases

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Medicinal plants continue to be used in various cultures of the world as safe therapeutic agents against various issues including pain and inflammation which underlie almost every disease process. In Ghanaian traditional medicine, various parts of several plants have been used alone or in combination of therapies for the treatment of various painful inflammatory conditions. In this chapter, the anti-inflammatory and analgesic (antinociceptive) properties of selected medicinal plants from Ghana are reviewed. Evidence of pharmacological activities of crude extracts and fractions in in-vitro and in-vivo models, bioactive anti-inflammatory and antinociceptive compounds isolated as well as possible mechanisms of anti-inflammatory and antinociceptive action are discussed.

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Section: Anopyxis Klaineana (Pierre) Engl (Rhizophoraceae)mentioning

confidence: 73%

Analgesic and Anti-Inflammatory Effect of Ghanaian Medicinal Plants

Asante-Kwatia¹,

Mensah²,

Baidoo³

2020

Medicinal Plants - Use in Prevention and Treatment of Diseases

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“…The 1H and 13 C NMR signal patterns of C-20 to C-27 were very close to those of tirucallane triterpenes with the same side chain. 32–34 Although the configuration at C-20 was not clear, the structure of 7 was concluded to be cycloarta-1,24-diene-3,23-dion-21-oic acid.…”

Section: Resultsmentioning

confidence: 99%

Kleinhospitine E and Cycloartane Triterpenoids from Kleinhovia hospita

et al. 2018

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A novel cycloartane triterpenoid alkaloid, kleinhospitine E (1), six new cycloartane triterpenoids (2-7), three known cycloartane triterpenoids (8-10), and taraxerone (11) were isolated from a methanol extract of Kleinhovia hospita. Their structures were elucidated by 1D- and 2D-NMR spectroscopy as well as HRMS analysis. The absolute configurations of all isolated compounds were determined from their ECD spectra by comparison with theoretical values. Kleinhospitine E (1) is the first cycloartane alkaloid possessing an unusual γ-lactam with an oxopropylidene side chain. Compounds 2, 3, and 6 were assigned as cycloartane triterpenoids with a 9α,10α-cyclopropyl ring, which is found rarely among naturally occurring compounds, while 4 and 5 were established as isomers of compound 3 containing a 21,23-diacetal side chain. Biological evaluation revealed that compounds 4 and 9 exhibited more potent antiproliferative activities against a multidrug-resistant tumor cell line compared with its parent chemosensitive cell line. Furthermore, compound 6 exhibited submicromolar anti-HIV activity.

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“…121 Other euphanes include the antibacterial toosendanin A 326 from Melia toosendan 122 and 25-methoxy-8,23-euphadien-3b-ol 327 from Euphorbia pekinensis. 123 New tirucallane derivatives include 3b-O-tigloylmelianol 328 from Guarea kunthiana, 124 congoensins A 329 and B 330 from the bark of Entandrophragma congoënse, 125 compounds 331, 332 and 333 from Anopyxis klaineana, 126 cutirucins A 334-I 342 from the fruit of Ficus carica, 127 24,25-dihydrolimocinol 343 from Melia azadirachta 128 and secotiaminic acid 344 from Entandrophragma congoense. 129 Paramigniosides A-E are tirucallane saponins from Paramignya scandens, all with the same genin 345.…”

Section: The Dammarane Groupmentioning

confidence: 99%