Anti-Influenza Activity of Betulinic Acid from Zizyphus jujuba on Influenza A/PR/8 Virus

Hong, Eun Hye; Song, Jeho; Kang, Kyo Bin; Sung, Sang Hyun; Ko, Hyun‐Jeong; Yang, Heejung

doi:10.4062/biomolther.2015.019

Cited by 77 publications

(45 citation statements)

References 17 publications

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“… Note . Present study, NMR 500 MHz, C 5 D 5 N‐ d 5 , 13 C measured at 125 MHz, 1 H measured at 500 MHz, compared with Hong et al (), NMR 400 MHz, C 5 D 5 N‐ d 5 , 13 C measured at 100 MHz, 1 H measured at 400 MHz.…”

Section: Discussionsupporting

confidence: 56%

The phytochemical and anti‐inflammatory studies of Dillenia suffruticosa leaves

Abubakar

Al-Mansoub

Murugaiyah

et al. 2019

Phytotherapy Research

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The Dillenia suffruticosa leaves (Dilleniaceae), a folk medicine recommended in Southeast Asia for treating inflammation, were phytochemically studied for the first time and assessed for suppression of λ‐carrageenan‐induced paw oedema in rats. The crude methanolic extract orally administered at 5,000 mg/kg, displayed no toxicity and at 250 to 1,000 mg/kg significantly suppressed the paw oedema. Two‐isolated triterpenoids, betulinic acid (1) and koetjapic acid (2) orally administered at 50 mg/kg, significantly reduced the paw oedema, (p < 0.001) and (p < 0.005) at the fourth h onwards to 47.36% ± 2.23 and 53.43% ± 7.09, respectively, from 95.90% ± 6.88 oedema induced by λ‐carrageenan alone. 1 and the isolated flavonoids of vitexin (3), tiliroside (4), and kaempferol (5), displayed moderately more of cyclooxygenase (COX)‐2 than COX‐1 enzyme inhibition, whereas 2 was slightly more inhibition of COX‐1. The in silico molecular docking studies provided support to the in vitro COX studies that the isolated compounds formed H‐bonding with the amino acid residues at the COX‐2 catalytic sites. The triterpenoids were bound to the peroxidase, possibly inhibiting the peroxidase reaction, whereas the flavonoids interacted more at the cyclooxygenase, resembling celecoxib, therefore providing evidences that these compounds were responsible for the anti‐inflammatory properties of D. suffruticosa.

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Section: Discussionsupporting

confidence: 56%

The phytochemical and anti‐inflammatory studies of Dillenia suffruticosa leaves

Abubakar

Al-Mansoub

Murugaiyah

et al. 2019

Phytotherapy Research

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“…, anti-oxidant (Dahiru and Obidoa, 2008), anti-allergic (Naika et al, 2013), antiinflammatory (Cardozoa et al, 2011) and anti-influenza activity (Hong et al, 2015). The effects of Z. spina-christi extract on the nervous system such as analgesic and anti-depressant activities have also been reported in previous studies (Adzu et al, 2003, Dahiru andObidoa, 2008).…”

mentioning

confidence: 65%

Effect of hydro-alcoholic extract of Ziziphus spina-christi against scopolamine-induced anxiety in rats

Setorki¹

2016

Bangladesh J Pharmacol

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The aim of this study was to observe the effect of Ziziphus spina-christi extract against anxiety related behavior induced by scopolamine. Rats were randomly divided into six groups, each group consists of eight rats. Vehicle group received distilled water, negative control received scopolamine (1 mg/kg) and positive control received diazepam (1 mg/mL). Experimental groups received Z. spina-christi extract (50, 100 and 200 mg/kg IP) 30 min after scopolamine injection. Anxiety related behaviors were assessed using the elevated plus maze. The rotarod test was used to evaluate motor coordination. Administration of Z. spina-christi extract (200 mg/kg) significantly increased the time spent in the open arm of elevated plus maze. The extract also reduced the percentage of closed arms entries and time spent in the closed arms. Different concentration of Z. spina-christi extract didn’t affect motor coordination and balance. Hydro-alcoholic extract of Z. spina-christi significantly ameliorate scopolamine-induced anxiety.Video clip<a href="https://youtube.com/v/LTHNppf_Euo">Elevated plus maze</a>: 1 min 58 sec

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“…Of interest, some of these agents have been reported for the potential use as anti-HIV agents (Řezanka et al, 2009), while oleanolic acid that might function as a broad spectrum entry inhibitor of influenza viruses (Yang et al, 2018). On the other side, betulinic acid has been demonstrated useful in reducing inflammation and pulmonary edema induced by influenza virus (Hong et al, 2015), and potassium canrenoate, the main metabolite of spironolactone in vivo, is an anti-aldosteronic/diuretic used in the treatment of hypertension patients. Finally, several GPBAR1 and FXR ligands, as bile acid derivatives, have been proved to exert beneficial effect in immune disorders (Fiorucci et al, 2018) and among these, BAR501, the first example of C-6β-substituted UDCA derivative with potent and selective GPBAR1 activity, has been recently demonstrated a promising lead in attenuating inflammation and immune dysfunction by shifting the polarization of colonic macrophages from the inflammatory phenotype M1 to the anti-inflammatory phenotype M2, increasing the expression of IL-10 gene transcription in the intestine and enhanced secretion of IL-10 by macrophages (Biagioli et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Hijacking SARS-Cov-2/ACE2 receptor interaction by natural and semi-synthetic steroidal agents acting on functional pockets on receptor binding region

Carino

Moraca

Fiorillo

et al. 2020

Preprint

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The coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by the severe acute respiratory syndrome coronavirus (SARS)-CoV-2. In the light of the urgent need to identify novel approaches to be used in the emergency phase, a largely explored strategy has been the repurpose of clinically available drugs as new antivirals, by targeting different viral proteins. In this paper, we describe a drug repurposing strategy based on a virtual screening of druggable pockets located in the central -sheet core of the SARS-CoV-2 Spike protein RBD supported by in vitro tests identifying several steroidal derivatives as SARS-CoV-2 entry inhibitors. Our results demonstrate that several potential binding sites exist in the SARS CoV-2 S protein, and that the occupancy of these pockets reduces the ability of the S protein RBD to bind to the ACE2 consensus in vitro. In particular, natural occurring and clinically available steroids as glycyrrhetinic and oleanolic acids, as well as the bile acids derivatives glyco-UDCA and obeticholic acid have been shown to be effective in preventing virus entry in the case of low viral load. All together, these results might help to define novel approaches to reduce the viral load by using SARS-CoV-2 entry inhibitors.

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Anti-Influenza Activity of Betulinic Acid from Zizyphus jujuba on Influenza A/PR/8 Virus

Cited by 77 publications

References 17 publications

The phytochemical and anti‐inflammatory studies of Dillenia suffruticosa leaves

The phytochemical and anti‐inflammatory studies of Dillenia suffruticosa leaves

Effect of hydro-alcoholic extract of <i>Ziziphus spina-christi</i> against scopolamine-induced anxiety in rats

Hijacking SARS-Cov-2/ACE2 receptor interaction by natural and semi-synthetic steroidal agents acting on functional pockets on receptor binding region

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