Anti-influenza virus effects of crude phenylethanoid glycosides isolated from ligustrum purpurascens via inducing endogenous interferon-γ

Hu, Xiaopeng; Shao, Min-ming; Song, Xun; Wu, Xuli; Qi, Ling; Zheng, Kai; Liu, Fan; Liao, Chien-Chang; Li, Chenyang; He, Jiang; Hu, Yingjie; Wu, Haiqiang; Li, Shihe; Zhang, Jian; Zhang, Fengxue; He, Zhendan

doi:10.1016/j.jep.2015.07.019

Cited by 29 publications

(23 citation statements)

References 35 publications

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“…TPG significantly decreased the mouse lung index (p < 0.05), alleviated influenza-induced lethality and clinical symptoms, and subsequently enhanced mouse survival (p < 0.05). In vitro, TPG inhibited influenza A virus H 1 N 1 infection of MDCK cells in a hemagglutination assay [89]. Besides, many pure PhGs also possessed potent antibacterial activity.…”

Section: Antibacterial and Antivirus Activitymentioning

confidence: 97%

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

2016

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Phenylethanoid glycosides (PhGs) are widely distributed in traditional Chinese medicines as well as in other medicinal plants, and they were characterized by a phenethyl alcohol (C 6 -C 2 ) moiety attached to a β-glucopyranose/β-allopyranose via a glycosidic bond. The outstanding activity of PhGs in diverse diseases proves their importance in medicinal chemistry research. This review summarizes new findings on PhGs over the past 10 years, concerning the new structures, their bioactivities, including neuroprotective, anti-inflammatory, antioxidant, antibacterial and antivirus, cytotoxic, immunomodulatory, and enzyme inhibitory effects, and pharmacokinetic properties.

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Section: Antibacterial and Antivirus Activitymentioning

confidence: 97%

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

2016

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“…Because conducting research investigations on the thymuses of HIV-infected humans (Verinaud et al 2004) is difficult, many animal model systems have been developed. The simian immunodeficiency virus (SIV)-infected monkey model is much better than the feline and murine models, on the basis that this species not only acts as a natural host for the infection, but also offers Duan et al 2015;Hu et al 2016;Liu et al 2014 Parasites…”

Section: Pathogenic Infections and Ati Viral Infections And Atimentioning

confidence: 99%

“…This unique mechanistic insight might therefore lead to better preventive measures as well as a therapeutic tool to reverse the influenza A(H1N1)pdm09-induced ATI (Liu et al 2014). Very recently, in vitro and in vivo studies demonstrated that oral administration of phenylethanoid glycosides extracted from Ligustrum purpurascens has a protective effect that involved increasing the production of IFN-γ in IFN-γ knockout mice during an infection with H1N1 (Hu et al 2016). This research focused on mouse serum and lungs along with a secondary lymphoid organ (spleen).…”

Section: Paracoccidioides Brasiliensismentioning

confidence: 99%

Acute Thymic Involution and Mechanisms for Recovery

Ansari

Liu

2017

Arch. Immunol. Ther. Exp.

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“…glycoside (LPG) can inhibit IFV-A replication (A/FM/1/47 H1N1, FM1) in vitro and in vivo by inducing IFN-g [143]. Oral administration of 900 mg/kg LPG daily for 5 days protects 30% of mice from a lethal infection of IFV-A (H1N1) [143].…”

Section: Ifv-a and Sars-cov Infection Induce Inflammation In Vivomentioning

confidence: 99%

Repurposing host-based therapeutics to control coronavirus and influenza virus

Wang

2019

Drug Discovery Today

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Teaser This communication focuses on the repurposing of clinically approved drugs and promising preclinical drug candidates for therapeutic development of host-based antiviral agents to control diseases caused by coronavirus and influenza virus.The development of highly effective antiviral agents has been a major objective in virology and pharmaceutics. Drug repositioning has emerged as a cost-effective and time-efficient alternative approach to traditional drug discovery and development. This new shift focuses on the repurposing of clinically approved drugs and promising preclinical drug candidates for the therapeutic development of host-based antiviral agents to control diseases caused by coronavirus and influenza virus. Host-based antiviral agents target host cellular machineries essential for viral infections or innate immune responses to interfere with viral pathogenesis. This review discusses current knowledge, prospective applications and challenges in the repurposing of clinically approved and preclinically studied drugs for newly indicated antiviral therapeutics.

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Anti-influenza virus effects of crude phenylethanoid glycosides isolated from ligustrum purpurascens via inducing endogenous interferon-γ

Cited by 29 publications

References 35 publications

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

Phenylethanoid Glycosides: Research Advances in Their Phytochemistry, Pharmacological Activity and Pharmacokinetics

Acute Thymic Involution and Mechanisms for Recovery

Repurposing host-based therapeutics to control coronavirus and influenza virus

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