Anti-influenza virus phytochemicals from Radix Paeoniae Alba and characterization of their neuraminidase inhibitory activities

Zhang, Tianbo; Lo, Chi‐Fai; Xiao, Mengjie; Cheng, Ling; Mok, Chris Ka Pun; Shaw, Pang‐Chui

doi:10.1016/j.jep.2020.112671

Cited by 32 publications

(11 citation statements)

References 18 publications

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“…It has been shown that it affects mainly the virus' replication cycle by interacting with the active sites of caspase or protein synthesis. In the case of curcumin [60,69,100], gallic acid [101,102] and catechin [103,104], examples of an inhibitory effect on the influenza virus are shown. Those publications point out the different methods of inhibition for each compound.…”

Section: Mechanism Of Antiviral Activitymentioning

confidence: 99%

“…EGCG HCV suppressing by blocking virus entry via viral envelope proteins and inhibiting cell-to-cell transmission [25] HBV inhibition of DNA synthesis during virus replication [29] the duck Tembusu virus (DTMUV) reduction of the viral infection in BHK-21 cells, expressions of the viral E protein and virus titers. EGCG affects the adsorption step of the infection and replication stage of the virus in BHK-21 cells [106] chlorogenic acid infectious bursal disease virus inhibiting histamine production, NF-kB activation, which affects the production of the pro-inflammatory cytokines TNF-a and IL-1b [105] HBV inhibiting DNA of the virus by binding to HepG2.2.15 and HepG2.A64 [107] catechin influenza A virus binding to functional sites PHE47A and LEU43A, which inhibits M2 viral mRNA synthesis as well as M2 protein expression [103] dengue virus interaction with NS5 protein, by binding to amino acids Asn609, Asp663, His798 [104] gallic acid influenza A virus inhibition of replication of the virus, by binding to Arg152 of neuraminidase protein [101] paramyxoviruses affects replication cycle of the virus by inhibiting ribonucleotide reductase enzyme [102]…”

Section: Polyphenolmentioning

confidence: 99%

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Antiviral Properties of Polyphenols from Plants

Chojnacka

Skrzypczak

Izydorczyk

et al. 2021

Foods

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Polyphenols are active substances against various types of viral infections. Researchers have characterized methods of how to isolate polyphenols without losing their potential to formulate pharmaceutical products. Researchers have also described mechanisms against common viral infections (i.e., influenza, herpes, hepatitis, rotavirus, coronavirus). Particular compounds have been discussed together with the plants in the biomass in which they occur. Quercetin, gallic acid and epigallocatechin are exemplary compounds that inhibit the growth cycle of viruses. Special attention has been paid to identify plants and polyphenols that can be efficient against coronavirus infections. It has been proven that polyphenols present in the diet and in pharmaceuticals protect us from viral infections and, in case of infection, support the healing process by various mechanisms, i.e., they block the entry into the host cells, inhibit the multiplication of the virus, seal blood vessels and protect against superinfection.

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Section: Mechanism Of Antiviral Activitymentioning

confidence: 99%

Section: Polyphenolmentioning

confidence: 99%

Antiviral Properties of Polyphenols from Plants

Chojnacka

Skrzypczak

Izydorczyk

et al. 2021

Foods

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“…Three tannins in the aqueous extract of Paeonia lactiflora were found to inhibit the replication of influenza A virus in MDCK cells, and all three compounds significantly reduced the activity of neuraminidase (Zhang, Lo, et al. 2020 ). Recent studies have shown that porcine jujube exhibits antiviral activity against DENV-2 in Vero cells, and its anti-dengue properties are most likely attributable to its tannin compounds (Pong et al.…”

Section: Antiviral Constituents In Traditional Chinese Medicinesmentioning

confidence: 99%

Research progress on antiviral constituents in traditional Chinese medicines and their mechanisms of action

Chen

2022

Pharmaceutical Biology

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Context Viruses have the characteristics of rapid transmission and high mortality. At present, western medicines still lack an ideal antiviral. As natural products, many traditional Chinese medicines (TCM) have certain inhibitory effects on viruses, which has become the hotspot of medical research in recent years. Objective The antiviral active ingredients and mechanisms of TCM against viral diseases was studied in combination with the pathogenesis of viral diseases and antiviral effects. Materials and methods English and Chinese literature from 1999 to 2021 was collected from databases including Web of Science, PubMed, Elsevier, Chinese Pharmacopoeia 2020 (CP), and CNKI (Chinese). Traditional Chinese medicines (TCM), active ingredients, antiviral, mechanism of action, and anti-inflammatory effect were used as the key words. Results The antiviral activity of TCM is clarified to put forward a strategy for discovering active compounds against viruses, and provide reference for screening antivirus drugs from TCM. TCM can not only directly kill viruses and inhibit the proliferation of viruses in cells, but also prevent viruses from infecting cells and causing cytophilia. It can also regulate the human immune system, enhance human immunity, and play an indirect antiviral role. Discussion and conclusion Based on the experimental study and antiviral mechanism of TCM, this paper can provide analytical evidence that supports the effectiveness of TCM in treating virus infections, as well as their mechanisms against viruses. It could be helpful to provide reference for the research and development of innovative TCMs with multiple components, multiple targets and low toxicity.

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“…6,7 Previous studies showed that PRA could be used for anti-inflammatory effects, 8 immune regulation, 9 treatment of depression 10,11 and anemia, 12 promotion of peripheral nerve regeneration, 13 and treatment of viral infections. 14 Modern studies of pharmacological mechanisms have found that the main active components of PRA include paeoniflorin, paeonol, paeonin, benzoylpaeoniflorin, albiflorin, oxypaeoniflorin, paeoniflorigenone, benzoic acid, β-sitosterol, and gal-lotannin. Paeoniflorin is the main pharmacological component of PRA.…”

Section: Pharmacological Studies On the Active Ingredients Of The Sixmentioning

confidence: 99%

<p>Research Progress on Classical Traditional Chinese Medicine Jieyu Pills in the Treatment of Depression</p>

Wang¹,

Miao²

2020

NDT

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Anti-influenza virus phytochemicals from Radix Paeoniae Alba and characterization of their neuraminidase inhibitory activities

Cited by 32 publications

References 18 publications

Antiviral Properties of Polyphenols from Plants

Antiviral Properties of Polyphenols from Plants

Research progress on antiviral constituents in traditional Chinese medicines and their mechanisms of action

<p>Research Progress on Classical Traditional Chinese Medicine Jieyu Pills in the Treatment of Depression</p>

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