Anti‐interleukin‐6 receptor therapy‐induced cutaneous symptoms resembling purpura fulminans in a patient with seropositive rheumatoid arthritis

A case of purpura fulminans precipitated by trimethoprim-sulfamethoxazole

“…9 Drug-induced liver injury may cause acquired protein C or S deficiency, 4,5 or enhanced release of coagulation factors, leading to a hyper-coagulable state. 6 Finally, drug excipients or contaminants may cause direct vasculopathy. 8 Some authors have refrained from speculating on a potential mechanism, but have argued for a causal link between drug exposure and purpura fulminans based upon close temporal association and absence of feasible alternative causes (e.g., infections).…”

Exhaustion and over-activation of immune cells in COVID-19: Challenges and therapeutic opportunities

“…IL-6 is a versatile cytokine that modulates both humoral and cellular immune responses. IL-6 is also important in the cellular response to inflammation and tissue damage during chronic infections [97]. In SARS-CoV-2 infections, the SARS N protein is a powerful inducer of IL-6 secretion [98].…”