Anti‐Interleukin Therapy in Asthma

Dunn, RM; Wechsler, M.E.

doi:10.1002/cpt.11

Cited by 27 publications

(17 citation statements)

References 89 publications

(88 reference statements)

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“…Chronic inflammatory changes in lungs lead to asthma. Modern understanding of its complex pathogenesis has allowed recognition of the heterogeneity of the disease across populations and the various inflammatory pathways that drive airway inflammation in asthma . Recent studies have shown that interleukins (IL‐4, IL‐5 and IL‐13) play important roles in both eosinophilic and non‐eosinophilic asthma .…”

Section: Diseases Associated With Chronic Inflammatory Responsementioning

confidence: 99%

“…Modern understanding of its complex pathogenesis has allowed recognition of the heterogeneity of the disease across populations and the various inflammatory pathways that drive airway inflammation in asthma . Recent studies have shown that interleukins (IL‐4, IL‐5 and IL‐13) play important roles in both eosinophilic and non‐eosinophilic asthma . It is also observed that IL‐6 levels are elevated in the lung epithelial cells of asthmatic patients compared with healthy controls .…”

Section: Diseases Associated With Chronic Inflammatory Responsementioning

confidence: 99%

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The potential of food protein‐derived anti‐inflammatory peptides against various chronic inflammatory diseases

2016

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Inflammation is considered as one of the major causes for the initiation of various chronic diseases such as asthma, cancer, cardiovascular disease, diabetes, obesity, inflammatory bowel disease, osteoporosis and neurological diseases like Parkinson's disease. Increasing scientific evidence has delineated that inflammatory markers such as TNF-α, IL-1, IL-6, IL-8 and CRP and different transcription factors such as NF-κB and STAT are the major key factors that regulate these inflammatory diseases. Food protein-derived bioactive peptides have been shown to exhibit anti-inflammatory activity by inhibiting or reducing the expression of these inflammatory biomarkers and/or by modulating the activity of these transcription factors. This review aims to discuss various molecular targets and underlying mechanisms of food protein-derived anti-inflammatory peptides and to explore their potential against various chronic inflammatory diseases. © 2015 Society of Chemical Industry.

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Section: Diseases Associated With Chronic Inflammatory Responsementioning

confidence: 99%

Section: Diseases Associated With Chronic Inflammatory Responsementioning

confidence: 99%

The potential of food protein‐derived anti‐inflammatory peptides against various chronic inflammatory diseases

2016

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“…As an important signal molecule, IL-4 can exacerbate airway inflammation through modulating eosinophils, lymphocytes, and air epithelial cells that play an important role in the pathogenesis of asthma. [6,7] IL-4 is reported to play a pivotal role in phenotypic or functional changes of bronchial asthma, such as airway hyperresponsiveness, eosinophil infiltration, and mucus overproduction, [8] while IL-6 is a small-size glycoprotein (21 kDa) that acts on epithelial and immune cells and is produced by cells from innate immune system, including macrophages, dendritic cells, mast cells, and neutrophils. Previous studies show that IL-6 can lead to asthma and other lung diseases via increasing airway mucus hypersecretion.…”

Section: Introductionmentioning

confidence: 99%

Associations of IL-4, IL-6, and IL-12 levels in peripheral blood with lung function, cellular immune function, and quality of life in children with moderate-to-severe asthma

Cui

Zhao²,

ShuXiang³

et al. 2017

Medicine

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Background:Pediatric asthma has gained increasing concerns with poorly understood pathogenesis. The purpose of this study was to explore the associations of interleukin-4 (IL-4), IL-6, and IL-12 levels in peripheral blood (PB) with lung function, cellular immune function, and children's quality of life (QOL) with moderate-to-severe asthma.Methods:A total of 1158 children with moderate-to-severe asthma (the experimental group) and 1075 healthy children (the control group) were recruited for our study. Enzyme-linked immunosorbent assay was used to detect IL-4, IL-6, and IL-12 levels. T lymphocytes were detected by alkaline phosphatase antialkaline phosphatase, and erythrocyte immune was measured by red blood cell C 3b receptor (RBC-C3bR) rosette-forming test. The forced expiratory volume in 1 second (FEV1) and peak expiratory flow (PEF) were detected, after which FEV1/forced vital capacity (FVC) was calculated before and after treatment. PedsQL3.0 was used to measure the effect of asthma on QOL of children, and the correlation between IL-4, IL-6, and IL-12 levels and the lung function and QOL was measured. Logistic regression analysis was applied to detect related factors of moderate-to-severe asthma of children.Results:After treatment, the decreased IL-4 and IL-6 levels and increased IL-12 level were revealed in the experimental group. The cellular immune function's disorder was significantly decreased, and an elevated CD3, CD4, CD8, and declined CD4/CD8 level was performed in T lymphocytes. RBC-C3bR was increased, and red blood cell immune complex (RBC-IC) was reduced in erythrocyte immune in comparison with those before treatment. Lung function parameters all increased. After treatment, the symptoms of asthma in children reduced with scores of increased QOL. IL-4 was positively related to RBC-IC, but negatively associated with the QOL score. IL-6 showed negative connection with CD4/CD8, RBC-C3bR, FEV1/FVC, and QOL score, and had positive connection with PEF. In addition, IL-12 was negatively correlated with PEF. The levels of IL-4, RBC-C3bR, FEV1/FVC, and PEF were independent risk factors for the prognosis of treatment for children with moderate-to-severe asthma.Conclusion:This study demonstrated that IL-4, IL-6, and IL-12 levels in PB were associated with lung function, cellular immune function, and QOL in children with moderate-to-severe asthma.

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“…Also, IL-4 is reported to play a pivotal role in phenotypic or functional changes of bronchial asthma, such as airway hyperresponsiveness, eosinophil infiltration, and mucus overproduction [24].…”

Section: Discussionmentioning

confidence: 99%

Association of STAT6 rs324011 Gene Polymorphism with Susceptibility of Atopic Bronchial Asthma in Egyptian Children

El-Gohary¹,

Wagih²,

Hamouda³

et al. 2018

Biochem Mol biol J

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Background: Bronchial asthma is a common disease with multiple determinants that include genetic variation. Signal transducer and activator of transcription 6 (STAT6) is a central molecule in the signal transduction pathway used by interleukin-4 (IL-4) in immunoglobulin E (IgE) isotype switching. Study Objective was to investigate whether single nucleotide polymorphism (SNP) in STAT6 is associated with atopic asthma susceptibility in Egyptian children and to correlate the effect of STAT6 gene polymorphism on IL-4 and total IgE levels.

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Anti‐Interleukin Therapy in Asthma

Cited by 27 publications

References 89 publications

The potential of food protein‐derived anti‐inflammatory peptides against various chronic inflammatory diseases

The potential of food protein‐derived anti‐inflammatory peptides against various chronic inflammatory diseases

Associations of IL-4, IL-6, and IL-12 levels in peripheral blood with lung function, cellular immune function, and quality of life in children with moderate-to-severe asthma

Association of STAT6 rs324011 Gene Polymorphism with Susceptibility of Atopic Bronchial Asthma in Egyptian Children

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