Anti-Leishmania Effects of Volatile Oils and Their Isolates

Fampa, Patrı́cia; Florencio, Melissa; Santana, Raissa Couto; Rosa, Dayana; Soares, Deivid Costa; Guedes, Herbert Leonel de Matos; Cordeiro-da-Silva, Anabela; Chaves, Douglas Siqueira de Almeida; Pinto-da-Silva, Lúcia Helena

doi:10.1007/s43450-021-00146-5

Cited by 11 publications

(8 citation statements)

References 82 publications

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“…In general, pharmacological studies of EOs suggest that major identified components could be responsible for the biological activity. However, some studies did not correlate the main compound with the antiprotozoal effect [38][39][40]. Thus, using the present model, we selected molecules present in EOs that can influence in the antiprotozoal activity of studied EOs, and could suggest other EOs based in the complete chemical composition and not only in the major components.…”

Section: Resultsmentioning

confidence: 99%

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Machine Learning Analysis of Essential Oils from Cuban Plants: Potential Activity against Protozoa Parasites

et al. 2022

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Essential oils (EOs) are a mixture of chemical compounds with a long history of use in food, cosmetics, perfumes, agricultural and pharmaceuticals industries. The main object of this study was to find chemical patterns between 45 EOs and antiprotozoal activity (antiplasmodial, antileishmanial and antitrypanosomal), using different machine learning algorithms. In the analyses, 45 samples of EOs were included, using unsupervised Self-Organizing Maps (SOM) and supervised Random Forest (RF) methodologies. In the generated map, the hit rate was higher than 70% and the results demonstrate that it is possible find chemical patterns using a supervised and unsupervised machine learning approach. A total of 20 compounds were identified (19 are terpenes and one sulfur-containing compound), which was compared with literature reports. These models can be used to investigate and screen for bioactivity of EOs that have antiprotozoal activity more effectively and with less time and financial cost.

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Section: Resultsmentioning

confidence: 99%

“…Trel [47]; while the rest of EOs displayed activity only against kinetoplastid parasites from Alpinia speciosa K. Schum. [39], Artemisia absinthium L. [42], Piper cubeba L. [48], and Thymus hirtus sp. algeriensis Boiss.…”

Section: Figurementioning

confidence: 99%

Machine Learning Analysis of Essential Oils from Cuban Plants: Potential Activity against Protozoa Parasites

et al. 2022

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“…EOs are plant-derived natural products consisting of complex mixtures of volatile, lipophilic, low molecular weight compounds, with terpenoids and phenylpropanoids among their most common constituents [ 12 ], in which hydrocarbons and oxygenated compounds stand out [ 13 ]. The composition of EOs may be influenced by several factors, such as water availability, soil composition, climate, nutrients, organ used for extraction, pathogen attack, or type of extraction [ 14 ]. They play an important ecological role in plants by attracting pollinators and beneficial insects, protecting from heat and cold, and being used as chemical defenses against pests, pathogenic microorganisms, or vertebrate predators [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…EOs have pharmacological interest because of their biocidal effects on pathogenic microorganisms, among other properties [ 16 ]. They present a broad pharmacological spectrum that includes analgesic, sedative, anti-inflammatory, antispasmodic, antimicrobial, antiprotozoal, and anthelmintic properties [ 16 , 17 ], as well as insecticidal effects [ 18 ], and can be used to overcome toxicity and the emergence of drug-resistant pathogens associated with routine treatments [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Trypanosomatidae Activity of Essential Oils and Their Main Components from Selected Medicinal Plants

et al. 2023

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Kinetoplastida is a group of flagellated protozoa characterized by the presence of a kinetoplast, a structure which is part of a large mitochondria and contains DNA. Parasites of this group include genera such as Leishmania, that cause disease in humans and animals, and Phytomonas, that are capable of infecting plants. Due to the lack of treatments, the low efficacy, or the high toxicity of the employed therapeutic agents there is a need to seek potential alternative treatments. In the present work, the antiparasitic activity on Leishmania infantum and Phytomonas davidi of 23 essential oils (EOs) from plants of the Lamiaceae and Asteraceae families, extracted by hydrodistillation (HD) at laboratory scale and steam distillation (SD) in a pilot plant, were evaluated. The chemical compositions of the EOs were determined by gas chromatography-mass spectrometry. Additionally, the cytotoxic activity on mammalian cells of the major components from the most active EOs was evaluated, and their anti-Phytomonas and anti-Leishmania effects analyzed. L. infantum was more sensitive to the EOs than P. davidi. The EOs with the best anti-kinetoplastid activity were S. montana, T. vulgaris, M. suaveolens, and L. luisieri. Steam distillation increased the linalyl acetate, β-caryophyllene, and trans-α-necrodyl acetate contents of the EOs, and decreased the amount of borneol and 1,8 cineol. The major active components of the EOs were tested, with thymol being the strongest anti-Phytomonas compound followed by carvacrol. Our study identified potential treatments against kinetoplastids.

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