Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin

Mishra, Kirti; Dash, A. P.; Swain, Bijay K; Dey, Nrisingha

doi:10.1186/1475-2875-8-26

Cited by 125 publications

(83 citation statements)

References 28 publications

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“…(Rubiaceae), etc. (Sharma & Sharma, 2000;Dua et al, 2004;Mishra et al, 2009). The assay is primarily based on the inhibition of the mature ring stages of the parasites, i.e., schizonts.…”

Section: Discussionmentioning

confidence: 99%

In vitroantiplasmodial and antimicrobial potential ofTagetes erectaroots

Gupta

Vasudeva

2010

Pharmaceutical Biology

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“…(Rubiaceae), etc. (Sharma & Sharma, 2000;Dua et al, 2004;Mishra et al, 2009). The assay is primarily based on the inhibition of the mature ring stages of the parasites, i.e., schizonts.…”

Section: Discussionmentioning

confidence: 99%

In vitroantiplasmodial and antimicrobial potential ofTagetes erectaroots

Gupta

Vasudeva

2010

Pharmaceutical Biology

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“…Mishra et al (2009) have reported on the methanolic extract of Andrographis paniculata which was tested in vitro on choloroquine-sensitive and resistant strains of Plasmodium falciparum for its antimalarial activity. In vivo activity demonstrated higher antimalarial effect at low concentration within 24-h incubation period (Nik et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Anthelmintic activity of botanical extracts against sheep gastrointestinal nematodes, Haemonchus contortus

Kamaraj¹,

Rahuman²,

Elango³

et al. 2010

Parasitol Res

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The source of chemical anthelmintics (levamisole, flubendazole, and thiabendazole) had limited the success of gastrointestinal nematodiasis control in sheep and goats and thus awakened interest in the study of medicinal plant extracts as alternative sources of anthelmintics. The egg hatching and larvicidal effect of indigenous plant extracts were investigated against the sheep parasite, Haemonchus contortus. The purpose of the present study was to assess the efficacy of leaf, bark, and seed ethyl acetate, acetone and methanol extracts of Andrographis paniculata (Burm.f.) Wall. ex Nees., Anisomeles malabarica (L.) R. Br., Annona squamosa L., Datura metel L., and Solanum torvum Swartz were tested against the parasitic nematode of small ruminants H. contortus using egg hatch assay (EHA) and larval development assay (LDA). The assays were run in 24-well cell culture plates at room temperature with five replicates. All plant extracts showed moderate parasitic effects after 48 and exposure for egg hatching and LDA, respectively; however, 100% egg hatching and larvicidal inhibition were found in the methanol extracts of A. paniculata, A. squamosa, D. metel, and S. torvum at 25 mg/ml and the effect was similar to positive control of Albendazole (0.075 mg/ml) and Ivermectin (0.025mg/ml) against H. contortus, respectively. The EHA result showed the ED(50) of methanol extracts of A. paniculata and D. metel, which were 2.90 and 3.08 mg/ml, and in larval development assay, the ED(50) was 4.26 and 3.86 mg/ml, respectively. These effects remain to be confirmed through in vivo studies.

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“…For example is the discovery of new antimalarial artemisinin and its derivatives from Artemisia annua that has been used in China for centuries traditionally. This proves that the medicinal plants is a natural source of new antimalarials that still need to be explored (Li and Wu, 1998 (Mishra et al, 2009), Enicostemma littorale (Soni and Gupta, 2009) and Quassia amara L. (Houel et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

<i>IN VIVO</i> ANTIPLASMODIAL ACTIVITY AND ACUTE TOXICITY OF STANDARDIZED EXTRACT OF <i>EURYCOMA LONGIFOLIA</i> JACK. ROOT TRADITIONALLY USED TO TREAT MALARIA

Wijayanti¹

2014

American Journal of Pharmacology and Toxicology

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A series of studies has been conducted to prove the Eurycoma longifolia Jack. root as an antimalarial. However, the in vivo antiplasmodial activity of E. longifolia Jack. root standardized extract and its lethal dose 50% (LD50) values is unknown. In vivo antiplasmodial activity was conducted on Plasmodium berghei infected Swiss mice as malaria model with 4-day suppression methods. Sixty mice were divided into 6 groups. Five groups as treatment groups received test material with 5 various doses and one group was given distilled water as control group. Parasite growth inhibition was calculated by comparing the parasitemia at treatment groups to control group. Effective dose that could inhibit parasite growth by 50% (ED50) was calculated by probit analysis based on the relationship between dose and the percentage of parasite growth inhibition. The results showed that E. longifolia Jack. root standardized extract have in vivo antiplasmodial activity in P. berghei infected Swiss mice with ED50 value of 28.78 mg kg −1 . Acute toxicity testing was conducted on 60 mice, divided into 6 groups. Five groups received test materials with 5 various doses as a single dose orally. One other group was given distilled water as control group. Each animal was observed for the first 24 h and observation was continued for 14 days. The lethal dose 50% (LD50) was calculated by probit analysis based on the number of animal deaths that occurred within 24 h after the administration of the test material. The results showed that the LD50 value of E. longifolia Jack. root standardized extract was 6128.71 mg kg −1 . Therapeutic Index was calculated as ratio of the LD50 and ED50 with results 212.95. It showed high therapeutic index which indicated that E. longifolia Jack. root standardized extract has low toxicity.

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Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin

Cited by 125 publications

References 28 publications

In vitroantiplasmodial and antimicrobial potential ofTagetes erectaroots

In vitroantiplasmodial and antimicrobial potential ofTagetes erectaroots

Anthelmintic activity of botanical extracts against sheep gastrointestinal nematodes, Haemonchus contortus

<i>IN VIVO</i> ANTIPLASMODIAL ACTIVITY AND ACUTE TOXICITY OF STANDARDIZED EXTRACT OF <i>EURYCOMA LONGIFOLIA</i> JACK. ROOT TRADITIONALLY USED TO TREAT MALARIA

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