2020
DOI: 10.33448/rsd-v9i10.8817
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Anti-malarial activity and toxicity of Aspidosperma nitidum Benth: a plant used in traditional medicine in the Brazilian Amazon

Abstract: The objective of this work was to evaluate the antiplasmodial activity and toxicity of the extract and fractions obtained from the bark of Aspidosperma nitidum. The ethanol extract obtained from the powdered bark of plants was acid-base partitioned and phytochemically analyzed. The antiplasmodial activity, in vivo antimalarial activity and in vitro cytotoxicity were acessed. The selectivity index (SI) was calculated. The acute oral toxicity and pathological effects, of the ethanol extract was evaluated in mice… Show more

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Cited by 8 publications
(6 citation statements)
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“…The trunk barks of A. nitidum were dried in an oven (40 °C for 7 days; Medicate Medical Products, model MD 1.2), grounded, and subjected to maceration (7 days) to obtain the EE, which was subjected to an acid–base partition, resulting in the neutral (FN) and alkaloid fractions (FA) 43 . The EE was also subjected to extraction under reflux, yielding the following fractions: hexane (FrHEX), dichloromethane (FrDCL), ethyl acetate (FrAcOEt) and methanol (FrMeOH) 44 .…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The trunk barks of A. nitidum were dried in an oven (40 °C for 7 days; Medicate Medical Products, model MD 1.2), grounded, and subjected to maceration (7 days) to obtain the EE, which was subjected to an acid–base partition, resulting in the neutral (FN) and alkaloid fractions (FA) 43 . The EE was also subjected to extraction under reflux, yielding the following fractions: hexane (FrHEX), dichloromethane (FrDCL), ethyl acetate (FrAcOEt) and methanol (FrMeOH) 44 .…”
Section: Methodsmentioning
confidence: 99%
“…A linear elution gradient was used: 70–30% of eluent B for 15 min, 60–40% of eluent B for 20 min and 50–100% of eluent B for 25 min. The temperature was maintained above 26 °C, flow of 1 mL/min, UV detection at 220–400 nm 43 .…”
Section: Methodsmentioning
confidence: 99%
“…Brandão et al [ 165 ] identified that the ethanolic extract and alkaloid fraction of Aspidosperma nitidum , an Amazonian medicinal plant, reduced parasitemia by 80% on the 5th day of P. berghei -infection in mice; however, this reduction was not sustained until the 8th day of infection. In addition, the antiplasmodial activity of the ethanolic extract of A. nitidum was identified in vitro against a chloroquine-resistant P. falciparum clone.…”
Section: Antioxidant Therapy In Malariamentioning
confidence: 99%
“…Este trabalho utilizou o método comparativo, do tipo quali-quantitativo, em que os estudos foram compilados e, posteriormente, avaliados os potenciais das atividades farmacológicas de M. citrifolia comparando com os controles positivos e negativos em testes in vitro e in vivo (Pereira, et al, 2018;Brandão, et al, 2020).…”
Section: Metodologiaunclassified