Anti-melanogenic effects of the essential oil from Citrus reticulata blossom on B16-F10 melanoma cells and in vivo zebrafish embryos

Kim, Sera; Cha, Jiyoon; Choi, Yun-Sang; Yang, Hye-Won; Jang, Hae Won; Kang, Min-Cheol

doi:10.1016/j.procbio.2023.09.011

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…During embryonic development, zebrafish will create melanin in their bodies; zebrafish exposed to EOs show a large decrease in this melanin, which might be indicative of an anti-melanogenic effect (Ho et al, 2023;Kim et al, 2023;Yan et al, 2023;Zhou et al, 2020). In addition, the anti-nociceptive effects of EOs on a zebrafish model of chemically induced pain were investigated (Batista et al, 2021;Lima et al, 2020).…”

Section: Zebrafish Models For the Evaluation Of Other Bioactivitiesmentioning

confidence: 99%

Zebrafish models for the evaluation of essential oils (EOs): A comprehensive review

Wang,

Yu,

Ding

et al. 2023

Qual. Assur. Saf. Crops Foods

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Essential oils (EOs) derived from crops, especially aromatic plants, have been well-acknowledged to provide several health benefits for humans. Zebrafish as an unprecedented tool has been widely used as an excellent vertebrate model in labs owing to its many useful characteristics. Its applications for rapidly and economically screening and identifying toxicity, safety, and bioactivity of EOs may serve to meet the rising demand for nutraceuticals, food supplements, and natural cosmetics. In this study, we summarized the research progress of zebrafish models in evaluating EOs. In addition, toxicity, safety, and various bioactivities of EOs were summarized using a wide variety of readily applicable zebrafish models covering antioxidant, anti-inflammatory, angiogenesis inhibition, neuromodulation, anesthesia, anti-melanogenesis, analgesic activities, etc. In conclusion, zebrafish is a valuable animal model for evaluating the bioactivity and safety of EOs, and using such a model may contribute to speeding up the identification of novel EOs with potential health functions and quality assessment, which in turn boosts the recognition of aromatic plants as important industrial crops and encourages a healthier way of life.

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Section: Zebrafish Models For the Evaluation Of Other Bioactivitiesmentioning

confidence: 99%

Zebrafish models for the evaluation of essential oils (EOs): A comprehensive review

Wang,

Yu,

Ding

et al. 2023

Qual. Assur. Saf. Crops Foods

View full text Add to dashboard Cite

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Medicinal potential of adventitious root cultures of Hypericum perforatum: study on antioxidant stress and anti‐melanogenic properties

Guo,

Li,

Zhang

et al. 2024

J Sci Food Agric

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BACKGROUNDAdventitious root (AR) culture is an effective method for the production of Hypericum perforatum raw materials. However, the ARs are seldom utilized in practical applications. Therefore, this study investigated the effects of H. perforatum ARs on antioxidative stress and anti‐melanogenesis, aiming for future applications in the development of related products.RESULTSIn the antioxidative stress experiment, tert‐butyl hydroperoxide‐stimulated HepG2 cells were pre‐treated with 12.5–50 μg mL−1 of AR ethanolic extract (HpE), which significantly increased (P < 0.05) cell viability and reduced reactive oxygen species levels. In alcohol‐stimulated mice, pre‐treatment with HpE (2.5–10 mg kg−1) enhanced the activities of superoxide dismutase, catalase, glutathione, ethanol dehydrogenase, and acetaldehyde dehydrogenase, while reducing the levels of alanine aminotransferase, aspartate aminotransferase, and triglycerides. In the anti‐melanogenesis experiment, α‐melanocyte‐stimulating hormone‐stimulated B16‐F10 mouse melanoma cells were pre‐treated with 25–100 μg mL−1 of HpE, resulting in increased tyrosinase activity and melanin content, along with a decrease in the expression levels of microphthalmia‐associated transcription factor, tyrosinase‐related proteins, and tyrosinase.CONCLUSIONHpE efficiently protects HepG2 cells from oxidative stress and safeguards the liver in mice by mitigating oxidative damage. Additionally, HpE inhibits melanin synthesis in B16‐F10 cells by suppressing tyrosinase activity. These findings suggest that H. perforatum ARs hold potential for use in the development of healthy foods, cosmetics, and pharmaceutical products aimed at antioxidative stress and anti‐melanogenesis. © 2024 Society of Chemical Industry.

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Anti-melanogenic effects of the essential oil from Citrus reticulata blossom on B16-F10 melanoma cells and in vivo zebrafish embryos

Cited by 2 publications

References 24 publications

Zebrafish models for the evaluation of essential oils (EOs): A comprehensive review

Zebrafish models for the evaluation of essential oils (EOs): A comprehensive review

Medicinal potential of adventitious root cultures of Hypericum perforatum: study on antioxidant stress and anti‐melanogenic properties

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