Anti-metastatic effect of midazolam on melanoma B16F10 cells in the lungs of diabetic mice

Preemptive Midazolam Can Reduce the Glycemic Stress Response to Surgery for Type-2 Diabetics Undergoing Simple Eye Surgery

“…Moreover, the obtained results were superior to that obtained by Tilak et al, [18] who reported non-significant differences in the percent of increase in BGC between patients who received midazolam or placebo and concluded that preoperative administration of midazolam did not cause attenuation of the hyperglycemic response compared to the placebo group. In support of the efficacy of hyperglycemic controlling effect of midazolam, experimental midazolam injection was found to prevent hyperglycemia-induced generation of reactive oxygen species and subsequent vascular leakage in the retinas [11,19] and lungs of diabetic mice.…”

Dopamine ameliorates hyperglycemic memory-induced vascular dysfunction in diabetic retinopathy

“…The mice were maintained under pathogen-free conditions in a temperature-controlled room with a 12-h light/dark cycle. Diabetic mice were generated by single daily intraperitoneal injections over 5 consecutive days of streptozotocin (50 mg/kg body weight; MilliporeSigma) freshly prepared in 100 mM citrate buffer (pH 4.5), as previously described (Seo et al, 2020). Mice with fasting blood glucose concentrations ≥19 mM and polyuria were considered diabetic.…”

Role of Amine Neurotransmitters and Their Receptors in Skin Pigmentation: Therapeutic Implication

“…Midazolam prevents cancer metastasis by hyperglycaemia by inhibiting intracellular events and subsequent vascular leakage from the lungs of diabetic mice through GABA A ( Figure 5 ) [ 139 ]. Diazepam improves melanogenesis and melanocyte dendritic and melanosome transport through the peripheral benzodiazepine receptor/cAMP/PKA pathway ( Figure 5 ) [ 140 ].…”

“…The combination of benzodiazepine, radiotherapy, and α-PD-L1 results in almost complete regression of treated tumours and a powerful abscopal effect mediated by increased infiltration of multifunctional CD8 + T cells [138]. Midazolam prevents cancer metastasis by hyperglycaemia by inhibiting intracellular events and subsequent vascular leakage from the lungs of diabetic mice through GABAA (Figure 5) [139]. Diazepam improves melanogenesis and melanocyte dendritic and melanosome transport through the peripheral benzodiazepine receptor/cAMP/PKA pathway (Figure 5) [140].…”

“…Additionally, research on how GABA is altered in skin pigmentation disorders and whether related compounds can have therapeutic effects in skin pigmentation disorders may also be needed. Midazolam prevents cancer metastasis by hyperglycaemia by inhibiting intracellular events and subsequent vascular leakage from the lungs of diabetic mice through GABA A (Figure 5) [139]. Diazepam improves melanogenesis and melanocyte dendritic and melanosome transport through the peripheral benzodiazepine receptor/cAMP/PKA pathway (Figure 5) [140].…”