Anti-Microbial Activity Of Aristolochic Acid From Root Of Aristolochia Bracteata Retz

Angalaparameswari, S.; Saleem, Tayyaba; Alagusundaram, M.; Ramkanth, S; Thiruvengadarajan, V. S.; Gnanaprakash, K.; Chetty, C. Madhusudhana; Pratheesh, G.

doi:10.5281/zenodo.1329064

2011

DOI: 10.5281/zenodo.1329064

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Anti-Microbial Activity Of Aristolochic Acid From Root Of Aristolochia Bracteata Retz

S. Angalaparameswari¹,

Tayyaba Saleem²,

M. Alagusundaram³

et al.

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Analysis of aristolochlic acids and evaluation of antibacterial activity of Aristolochia clematitis L.

Bartha

Tóth

Horváth

et al. 2019

BioFut

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Introduction Several Aristolochia species were used as medicinal herb across Europe and in recent years, their antimicrobial activity has also been investigated. Materials and methods In this study, A. clematitis was selected to evaluate the aristolochic acids I and II (AA I and AA II) concentrations and the antimicrobial activity of methanol, hexane, butanol, and ethyl acetate extracts of the root, stem, leaf, root, and fruit. AA I and AA II contents were measured by a validated high-performance liquid chromatography–ultraviolet method. Results Each fraction of the plant contained AA I and AA II and the root was found to have the highest contents of AA I (1.09%) and AA II (0.7454%). The minimum inhibitory concentrations of all extracts were determined by standard microdilution method. The fruit’s extracts showed the most efficient antimicrobial effect against both methicillin sensitive and resistant Staphylococcus aureus strains. Conclusion Correlation between the AA I and AA II concentrations and the antimicrobial effect was not found.

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Analysis of aristolochlic acids and evaluation of antibacterial activity of Aristolochia clematitis L.

Bartha

Tóth

Horváth

et al. 2019

BioFut

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Acute toxicity of Aristolochia longa L. of aqueous extract in mice

Merouani

Belhattab

2020

J. Drug Delivery Ther.

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Aristolochia longa L. (Aristolochiaceae) is widely used to treat breast cancer in Algerian traditional medicine. The present study was conducted to investigate the effects of ingestion of aqueous extracts of different parts of the plant on liver and kidney functions in wistar albinos mice. Acute oral toxicity was performed to determine DL50, this toxicity was carried out by the oral administration in single doses of 0–12 g/kg for tubers aqueous extracts and 2 g/kg and 5 g/kg for aerial and fruit aqueous extract respectively. General behavior, adverse effects and mortality were determined for up to 14 days. The animals were sacrificed and biochemical study was done. The acute oral toxicity result revealed that LD50 of the tubers and fruit aqueous extracts was respectively more than 12 g/kg and 5 g/kg, but DL50 of the aerial aqueous extract was at 5 g/kg. The result revealed also that liver and kidney function of different groups receiving high doses was affected as ASAT, ALAT, Urea, creatinine was significantly increased as compared to control group. Histological examination showed alterations of the renal parenchyma and the liver which is greater in animals treated with high dose. Thus, caution should be exercised with its usage. Keywords: Acute toxicity, Biochemical parameters, Histological examination Aristolochia longa L.

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Anti-Microbial Activity Of Aristolochic Acid From Root Of Aristolochia Bracteata Retz

Cited by 2 publications

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Analysis of aristolochlic acids and evaluation of antibacterial activity of Aristolochia clematitis L.

Analysis of aristolochlic acids and evaluation of antibacterial activity of Aristolochia clematitis L.

Acute toxicity of Aristolochia longa L. of aqueous extract in mice

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