Anti-microbial and Anti-diabetic Activity of Six Seaweeds Collected from the Red Sea, Egypt

Osman, Nehal A.H.K.; Siam, A. A.; El-Manawy, Islam M.; Jeon, You‐Jin

doi:10.21608/cat.2019.49157

Cited by 12 publications

(12 citation statements)

References 12 publications

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“…The data of the investigation of Osman et al [102], the methanolic extract of the brown seaweed Hormophysa cuneiformis was the most active species for antidiabetic activity that reached to 53% inhibition of α-glucosidase at the highest concentration (1000 µg/mL) with IC50 676.9 µg/mL. Additionally, a semi-purified phlorotannin fraction of Fucus vesiculosus (Ochrophyta, Phaeophyceae) (Figure 5k) shows promising inhibitory effects, particularly against the enzymes related to the diabetes α-amylase and α-glucosidase for which a greater inhibitory effect was observed compared to the pharmaceutical drug acarbose (IC50 = 2.8 and 0.82 µg/mL, respectively, against 206.6 µg/mL) [103].…”

Section: The Inhibitory Activity Of Algae On the Carbohydrate Hydroly...mentioning

confidence: 98%

Antioxidant and Antidiabetic Activity of Algae

Abo-Shady¹,

Gheda²,

Ismail³

et al. 2022

Preprint

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Currently, algae arouse a growing interest in the pharmaceutical and cosmetic area due to the fact that they have a great diversity of bioactive compounds with the potential for pharmacological, cosmetic, and nutraceutical applications. Many of these bioactive compounds are secondary metabolites whose amounts in the algae vary with varying environmental conditions. Free radicals and other active oxygen derivatives are recognized as a natural by-product of aerobic metabolism. However, reactive oxygen species directly participate in mechanisms related to various pathological states such as cancer, diabetes, atherosclerosis, Alzheimer's, and Parkinson's, among others. Diabetes mellitus (DM) is a metabolic disease resulting from changes in glucose metabolism and/or deficient production/action of insulin. This review has as its main objective to reveal the potential antioxidant and antidiabetic capacity of algae extracts.

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Section: The Inhibitory Activity Of Algae On the Carbohydrate Hydroly...mentioning

confidence: 98%

Antioxidant and Antidiabetic Activity of Algae

Abo-Shady¹,

Gheda²,

Ismail³

et al. 2022

Preprint

View full text Add to dashboard Cite

Currently, algae arouse a growing interest in the pharmaceutical and cosmetic area due to the fact that they have a great diversity of bioactive compounds with the potential for pharmacological, cosmetic, and nutraceutical applications. Many of these bioactive compounds are secondary metabolites whose amounts in the algae vary with varying environmental conditions. Free radicals and other active oxygen derivatives are recognized as a natural by-product of aerobic metabolism. However, reactive oxygen species directly participate in mechanisms related to various pathological states such as cancer, diabetes, atherosclerosis, Alzheimer's, and Parkinson's, among others. Diabetes mellitus (DM) is a metabolic disease resulting from changes in glucose metabolism and/or deficient production/action of insulin. This review has as its main objective to reveal the potential antioxidant and antidiabetic capacity of algae extracts.

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Section: Polysaccharides From Macroalgaementioning

confidence: 99%

“…This event is quite important in controlling blood glucose peaks after meals and food intake. Specifically, in one study, the inhibition of digestive enzymes with Fucus vesiculosus (Ochrophyta, Phaeophyceae) (Figure 7) extracts was demonstrated in comparison with the commercial drug acarbose [65]. There is a beneficial effect of the consumption of dietary fibers with certain diseases such as coronary heart disease, type 2 diabetes and some intestinal disorders [27].…”

Section: Polysaccharides From Macroalgaementioning

confidence: 99%

Algae Food Products as a Healthcare Solution

Tavares,

Cotas,

Valado

et al. 2023

Marine Drugs

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Diseases such as obesity; cardiovascular diseases such as high blood pressure, myocardial infarction and stroke; digestive diseases such as celiac disease; certain types of cancer and osteoporosis are related to food. On the other hand, as the world’s population increases, the ability of the current food production system to produce food consistently is at risk. As a result, intensive agriculture has contributed to climate change and a major environmental impact. Research is, therefore, needed to find new sustainable food sources. One of the most promising sources of sustainable food raw materials is macroalgae. Algae are crucial to solving this nutritional deficiency because they are abundant in bioactive substances that have been shown to combat diseases such as hyperglycemia, diabetes, obesity, metabolic disorders, neurodegenerative diseases and cardiovascular diseases. Examples of these substances include polysaccharides such as alginate, fucoidan, agar and carrageenan; proteins such as phycobiliproteins; carotenoids such as β-carotene and fucoxanthin; phenolic compounds; vitamins and minerals. Seaweed is already considered a nutraceutical food since it has higher protein values than legumes and soy and is, therefore, becoming increasingly common. On the other hand, compounds such as polysaccharides extracted from seaweed are already used in the food industry as thickening agents and stabilizers to improve the quality of the final product and to extend its shelf life; they have also demonstrated antidiabetic effects. Among the other bioactive compounds present in macroalgae, phenolic compounds, pigments, carotenoids and fatty acids stand out due to their different bioactive properties, such as antidiabetics, antimicrobials and antioxidants, which are important in the treatment or control of diseases such as diabetes, cholesterol, hyperglycemia and cardiovascular diseases. That said, there have already been some studies in which macroalgae (red, green and brown) have been incorporated into certain foods, but studies on gluten-free products are still scarce, as only the potential use of macroalgae for this type of product is considered. Considering the aforementioned issues, this review aims to analyze how macroalgae can be incorporated into foods or used as a food supplement, as well as to describe the bioactive compounds they contain, which have beneficial properties for human health. In this way, the potential of macroalgae-based products in eminent diseases, such as celiac disease, or in more common diseases, such as diabetes and cholesterol complications, can be seen.

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“…The methanolic extract of Hormophysa cuneiformis (Ochrophyta) was the most active, recording an inhibition activity of 53% for the α-glucosidase enzyme at the highest investigated concentration (1000 μg/mL) with an IC 50 of 676.9 μg/mL [ 100 ]. Additionally, a semi-purified phlorotannin fraction of Fucus vesiculosus (Ochrophyta, Phaeophyceae) ( Figure 5 k) showed potent inhibitory effects against α-amylase and α-glucosidase enzymes with IC 50 values of 2.8 and 0.82 μg/mL, respectively, compared to the pharmaceutical drug acarbose (IC 50 = 206.6 μg/mL) [ 101 ].…”

Section: Treatment Of Diabetesmentioning

confidence: 99%

Antioxidant and Antidiabetic Activity of Algae

Abo-Shady

Gheda

Ismail

et al. 2023

Life

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Currently, algae arouse a growing interest in the pharmaceutical and cosmetic area due to the fact that they have a great diversity of bioactive compounds with the potential for pharmacological and nutraceutical applications. Due to lifestyle modifications brought on by rapid urbanization, diabetes mellitus, a metabolic illness, is the third largest cause of death globally. The hunt for an efficient natural-based antidiabetic therapy is crucial to battling diabetes and the associated consequences due to the unfavorable side effects of currently available antidiabetic medications. Finding the possible advantages of algae for the control of diabetes is crucial for the creation of natural drugs. Many of algae’s metabolic processes produce bioactive secondary metabolites, which give algae their diverse chemical and biological features. Numerous studies have demonstrated the antioxidant and antidiabetic benefits of algae, mostly by blocking carbohydrate hydrolyzing enzyme activity, such as α-amylase and α-glucosidase. Additionally, bioactive components from algae can lessen diabetic symptoms in vivo. Therefore, the current review concentrates on the role of various secondary bioactive substances found naturally in algae and their potential as antioxidants and antidiabetic materials, as well as the urgent need to apply these substances in the pharmaceutical industry.

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Anti-microbial and Anti-diabetic Activity of Six Seaweeds Collected from the Red Sea, Egypt

Cited by 12 publications

References 12 publications

Antioxidant and Antidiabetic Activity of Algae

Antioxidant and Antidiabetic Activity of Algae

Algae Food Products as a Healthcare Solution

Antioxidant and Antidiabetic Activity of Algae

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